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anti-Rat (Rattus) Prothrombin Antikörper:
anti-Mouse (Murine) Prothrombin Antikörper:
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Human Monoclonal Prothrombin Primary Antibody für ELISA, WB - ABIN2192473
Yin, Wright, Wall, Grammas: Brain endothelial cells synthesize neurotoxic thrombin in Alzheimer's disease. in The American journal of pathology 2010
Show all 2 Pubmed References
Human Polyclonal Prothrombin Primary Antibody für IHC, ELISA - ABIN1583288
Fritze, Zhang, Li, Chai, Mulholland: Thrombin mediates vagal apoptosis and dysfunction in inflammatory bowel disease. in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2014
Human Polyclonal Prothrombin Primary Antibody für IF, WB - ABIN515438
Huang, Wu, Tseng, Chen, Hsieh, Chen: Increased prothrombin, apolipoprotein A-IV, and haptoglobin in the cerebrospinal fluid of patients with Huntington's disease. in PLoS ONE 2011
Human Polyclonal Prothrombin Primary Antibody für CyTOF, FACS - ABIN4900737
Jesmin, Gando, Zaedi, Prodhan, Sawamura, Miyauchi, Hiroe, Yamaguchi: Protease-activated receptor 2 blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates renal fibrin deposition in a rat model of acute renal failure. in Shock (Augusta, Ga.) 2009
Prothrombin morpholino-injected zebrafish embryos yielded an early phenotype exhibiting severe abnormalities that later showed occasional bleeding
The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.
Platelet derived microparticles formed in sepsis are a potent inducer of thrombin generation via phosphatidylserine exposure, and activation of both the intrinsic and extrinsic pathway of coagulation.
These findings imply that a thrombin-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.
mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.
Biglycan (zeige BGN Antikörper) plays a protective role during the progression of atherosclerosis in ApoE (zeige APOE Antikörper)-deficient mice by inhibiting thrombin generation.
allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (zeige GP1BA Antikörper)-binding and heparin-binding site of thrombin
thrombin/PAR-1 (zeige MARK2 Antikörper) interaction regulated MCP-1 (zeige CPT1B Antikörper), TF, MCSF (zeige CSF1 Antikörper) and IL-6 (zeige IL6 Antikörper) production.
Observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (zeige SERPINC1 Antikörper) nanoparticle therapeutics.
Thrombin-PAR1 (zeige F2R Antikörper) signaling, via nitric oxide and EPCR (zeige PROCR Antikörper), promotes hematopoietic stem cell (HSC (zeige FUT1 Antikörper)) mobilization.
Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.
Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 (zeige CDC25C Antikörper) and Ras-associating domains of phospholipase C epsilon (zeige PLCE1 Antikörper).
Thrombin, via PAR1 (zeige MARK2 Antikörper) activation, synergistically augments LPS (zeige IRF6 Antikörper)-induced Human endometrial endothelial cells production of chemokines involved in immune cell recruitment and survival, suggesting a mechanism by which intrauterine abruption and bacterial infection may together be associated with an aggravated uterine inflammatory response.
Clinical significance of prothrombin G20210A mutation in homozygous patients.
The prevalence of FVL (zeige F5 Antikörper) polymorphism (16.3 %) was higher in retinopathy of prematurity (ROP (zeige STXBP1 Antikörper)) patients than control subjects in this Turkish cohort. We suggest a possible association of FVL (zeige F5 Antikörper) mutation with ROP (zeige STXBP1 Antikörper) at the end of the study.
Data suggest that, for all coagulation proteins tested (prothrombin, factor X, activated factor VII, activated protein C), tighter binding to lipid bilayers (lower Kd) is observed as the proportion of anionic phospholipid increases. These studies were conducted in high-throughput screening using phospholipid bilayers in nanodiscs with multiplexed silicon photonic sensor (micro-ring resonator) array technology.
Factor Va reduced by 100-fold the apparent Kd of myosin for factor Xa (zeige F10 Antikörper) (Kd approximately 0.48 nM), primarily by reducing koff, indicating formation of a stable ternary complex of myosin:Xa:Va.
Over the first 500 s, approximately 92,000 molecules of thrombin were generated per surface TF molecule for the 250-mum-long coating.
EPCR (zeige PROCR Antikörper) occupancy recruits G-protein coupled receptor kinase 5 (zeige GRK5 Antikörper), thereby inducing beta-arrestin-2 (zeige ARRB2 Antikörper) biased PAR1 (zeige MARK2 Antikörper) signaling by both APC (zeige APC Antikörper) and thrombin. In
Data suggest that subtilisin, a serine protease secreted by non-pathogenic bacterium Bacillus subtilis, induces plasma clotting by proteolytically activating prothrombin with single "non-canonical" cleavage at Ala470-Asn471 bond.
An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII (zeige F8 Antikörper) by thrombin has been presented.
These studies clarify the role of PKCdelta (zeige PKCd Antikörper) in endothelial cell cytoskeleton regulation.
the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface.
novel pyranosic sulfated (zeige SULF1 Antikörper) arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated (zeige SULF1 Antikörper) polysaccharides and glycosaminoglycans
Exogenous delivery of thrombin enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.
the signaling pathways of MAPK (zeige MAPK1 Antikörper), MSK1 (zeige RPS6KA5 Antikörper), and NF-kappaB (zeige NFKB1 Antikörper) play important roles in thrombin-induced iNOS (zeige NOS2 Antikörper) expression in alveolar macrophages
High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.
Thrombin induces a sustained contraction in the normal pulmonary artery, by activating PAR(1 (zeige F2R Antikörper)) and thereby increasing the sensitivity of the myofilament to Ca(2 (zeige CA2 Antikörper)+).
kinetic and structural analysis of interactions between thrombin and the Factor XIII (zeige UGDH Antikörper) activation peptide
analysis of staphylocoagulase-mediated bovine prothrombin activation
thrombin and factor Xa (zeige F10 Antikörper) diffusion along the heparin molecule explains the effects of extended heparin chain lengths
A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.
thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (zeige UGDH Antikörper) and by receptor-mediated up-regulation of factor XIII (zeige UGDH Antikörper) synthesis
In conclusion, thrombin activates pro-MMP-2 (zeige MMP2 Antikörper) in the absence of elevated pro-MMP-2 (zeige MMP2 Antikörper) expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2 (zeige MMP2 Antikörper)
Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1 (zeige F2R Antikörper), RhoA (zeige RHOA Antikörper), and myocardin (zeige MYOCD Antikörper).
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
, cell division cycle 34 homolog
, serine protease
, ubiquitin-conjugating enzyme Cdc34
, ubiquitin-conjugating enzyme E2 R1
, mast cell chymase
, mast cell protease I
, coagulation factor 2
, prepro-coagulation factor II
, prothrombin B-chain
, C1 esterase
, complement C1s-A subcomponent
, complement component 1 subcomponent s-A
, complement component C1SA