Complement Factor H Proteine (CFH)

Complement Factor H Proteine (CFH)
Auf finden Sie aktuell 18 Complement Factor H (CFH) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Complement Factor H Antikörper (264) und Complement Factor H Kits (56) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 347 Complement Factor H Produkte verfügbar.
AHUS1, AMBP1, ARMD4, ARMS1, CFH, CFHL3, fH, FHL1, HF, HF1, HF2, HUS, im:7147412, Mud-1, NOM, Sas-1, Sas1, si:ch211-207o17.2
alle Proteine anzeigen Gen GeneID UniProt
CFH 12628 P06909
CFH 3075 P08603
CFH 155012  

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Am meisten referenzierte Complement Factor H Proteine

  1. Human Complement Factor H Protein expressed in Human Cells - ABIN2003293 : Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006 (PubMed)
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Weitere Proteine zu Complement Factor H Interaktionspartnern

Chimpanzee Complement Factor H (CFH) Interaktionspartner

  1. interaction between sialylated Neisseria gonorrhoeae and factor H [factor H]

Zebrafish Complement Factor H (CFH) Interaktionspartner

  1. Results report the molecular cloning and identification of complement factor H and complement factor H-like 1-4 (CFHL1 (zeige CFHR1 Proteine)-4) in Danio rerio.

Mouse (Murine) Complement Factor H (CFH) Interaktionspartner

  1. Factor H and Crry (zeige CR1L Proteine) are critical for regulating complement activation at distinct anatomic sites within the kidney.

  2. VEGF (zeige VEGFA Proteine) inhibition decreases local CFH and other complement regulators in the eye and kidney through reduced VEGFR2 (zeige KDR Proteine)/PKC-alpha (zeige PKCa Proteine)/CREB (zeige CREB1 Proteine) signaling.

  3. environmental factors can drive retinal disease in these mice when linked to complement deficits impairing immune function. Both groups of mice had similar levels of retinal amyloid beta accumulation. Consequently there is no direct link between this and inflammation in Cfh(-/-) mice.

  4. absence of plasma CfH conferred susceptibility to glomerulonephritis

  5. This new understanding of the complicated interactions of CFH in AMD (zeige AMD1 Proteine)-like pathology provides an improved foundation for the development of targeted therapies for AMD (zeige AMD1 Proteine)

  6. data suggest that altered interactions of Cfh with MDA-modified proteins may be relevant in explaining the effects of the Cfh variant.

  7. Cfh and Cfhr2 (zeige CFHR2 Proteine) genes are expressed in the mouse outer retina. Only Cfh mRNA was detected in the retinal pigment epithelium, but no protein.

  8. A spectrum of complement dysregulation was modeled on the APOE4 age related macular degeneration mouse model by crossing these mice to complement factor H knockout (cfh-/-) mice to test the impact of excess complement activation.

  9. Data indicate that co-deficiency of factor H (FH) and MASP-1/MASP-3 (zeige MASP1 Proteine) did not ameliorate either the plasma Complement C3 (zeige C3 Proteine) (C3) activation or glomerular C3 accumulation in FH-deficient mice.

  10. A2E accumulation altered retinal microglial complement regulation by decreasing complement factor H (and increasing complement factor B (zeige CFB Proteine) expression), favoring increased complement activation and lipofuscin deposition in the outer retina.

Human Complement Factor H (CFH) Interaktionspartner

  1. OCT (zeige Plxna2 Proteine) scans revealed lower retinal thickness in patients homozygous for CFH or ARMS2 (zeige ARMS2 Proteine), which was caused by a significantly reduced photoreceptor layer. The number and ultrastructure of drusen were also significantly different.

  2. VEGF (zeige VEGFA Proteine) inhibition decreases local CFH and other complement regulators in the eye and kidney through reduced VEGFR2 (zeige KDR Proteine)/PKC-alpha (zeige PKCa Proteine)/CREB (zeige CREB1 Proteine) signaling.

  3. CFH rs1061170 has an important effect on age at onset of MDD in Han Chinese and may therefore be related to early pathogenesis of MDD.

  4. Data suggest that disease-linked mutations in complement factor H (CFH) affect pivotal role of CFH in regulation of complement activation; mutations studied include those linked to atypical hemolytic uremic syndrome and age-related macular degeneration.

  5. Fibrinogen gamma chain (zeige FGG Proteine) and complement factor H were found to be bound as a protein complex in the plasma of a patient with advanced ovarian cancer

  6. Factor I binds C3b-Factor H between Factor H domains 2 and 3 and a reoriented C3b C-terminal domain and docks onto the first scissile bond, while stabilizing its catalytic domain for proteolytic activity.

  7. The VEGF (zeige VEGFA Proteine) haplotype TGA (zeige TBX1 Proteine) could be used as a marker for poor visual prognosis in Tunisian patients with neovascular AMD (zeige AMD1 Proteine) treated with bevacizumab.

  8. Two protective, low-frequency, non-synonymous variants were significantly associated with a decrease in age-related macular degeneration (AMD (zeige AMD1 Proteine))risk: A307V in PELI3 (zeige PELI3 Proteine) and N1050Y in CFH .We also identified a strong protective signal for a common variant (rs8056814) near CTRB1 associated with a decrease in AMD (zeige AMD1 Proteine) risk (logistic regression: OR = 0.71, P = 1.8 x 10-07).

  9. this study shows that RNA interference of factor H in dendritic cells increased alloantigen-specific T-cell proliferation

  10. monomeric CRP (zeige CRP Proteine) (mCRP) but not the pentameric form (pCRP) upregulates IL-8 (zeige IL8 Proteine) and CCL2 (zeige CCL2 Proteine) levels in retinal pigment epithelial cells. Complement factor H (FH) binds mCRP to dampen its proinflammatory activity. FH from AMD (zeige AMD1 Proteine) patients carrying the "risk" His402 polymorphism displays impaired binding to mCRP.

Pig (Porcine) Complement Factor H (CFH) Interaktionspartner

Complement Factor H (CFH) Protein Überblick

Protein Überblick

This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with Complement Factor H (CFH)

  • complement factor H (CFH)
  • complement factor H (cfh)
  • complement component factor h (Cfh)
  • complement factor H (Cfh)
  • AHUS1 Protein
  • AMBP1 Protein
  • ARMD4 Protein
  • ARMS1 Protein
  • CFH Protein
  • CFHL3 Protein
  • fH Protein
  • FHL1 Protein
  • HF Protein
  • HF1 Protein
  • HF2 Protein
  • HUS Protein
  • im:7147412 Protein
  • Mud-1 Protein
  • NOM Protein
  • Sas-1 Protein
  • Sas1 Protein
  • si:ch211-207o17.2 Protein

Bezeichner auf Proteinebene für Complement Factor H Proteine (CFH)

complement factor H , complement factor H related protein 3A4/5G4 , protein beta-1-H , H factor 1 (complement) , H factor 2 (complement) , adrenomedullin binding protein , age-related maculopathy susceptibility 1 , beta-1-H-globulin , beta-1H , factor H , factor H-like 1 , complement component factor H , complement inhibitory factor H , platelet complement factor H , complement regulator factor H

457601 Pan troglodytes
553060 Danio rerio
553297 Danio rerio
100399888 Callithrix jacchus
100451270 Pongo abelii
100465619 Ailuropoda melanoleuca
100600041 Nomascus leucogenys
12628 Mus musculus
3075 Homo sapiens
100051358 Equus caballus
155012 Rattus norvegicus
478952 Canis lupus familiaris
100733902 Cavia porcellus
100340175 Oryctolagus cuniculus
397525 Sus scrofa
280816 Bos taurus
429057 Gallus gallus
100174982 Ovis aries
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