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This is the first report of a survival disadvantage of EBV+ patients with CLL, and the first time that STAT5b (zeige STAT5B Proteine) expression is correlated with survival. The correlation of STAT5 expression with the presence of the virus, along with our survival correlations defines a subgroup of patients with CLL that may benefit from anti-STAT (zeige STAT1 Proteine) agents.
STAT5 signaling axis drives abnormal cell proliferation in autosomal dominant polycystic kidney disease.
O-GlcNAcylation and tyrosine phosphorylation act together to trigger pYSTAT5 levels and oncogenic transcription in neoplastic cells. A mutated hyperactive gain-of-function (GOF) STAT5 without O-GlcNAcylation resulted in decreased tyrosine phosphorylation, oligomerization and transactivation potential and complete loss of oncogenic transformation capacity.
p65 (zeige GORASP1 Proteine) activation triggered by TCR signaling could promote SNRPA (zeige SNRPA Proteine) transcription and 3' UTR shortening of STAT5B (zeige STAT5B Proteine). Thus we propose that the alternative polyadenylation switching of STAT5B (zeige STAT5B Proteine) induced by TCR activation is mediated by SNRPA (zeige SNRPA Proteine).
this study shows that musculin (zeige MSC Proteine) inhibits human T-helper 17 cell response to interleukin 2 (zeige IL2 Proteine) by controlling STAT5B (zeige STAT5B Proteine) activity
STAT5 interacted with minichromosome maintenance (MCM) complex, suggesting that STAT5 directly facilitates viral DNA replication by recruiting the helicase complex of the cellular DNA replication machinery to viral DNA replication centers.
Molecular interactions of EphA4 (zeige EPHA4 Proteine), growth hormone receptor (zeige GHR Proteine), Jak2 (zeige JAK2 Proteine), and STAT5B (zeige STAT5B Proteine) have been described.
High STAT5 phosphorylation is associated with systemic lupus erythematosus.
NPM1 (zeige NPM1 Proteine) downregulation by P-STAT5 is mediated by impairing the BRCA1-BARD1 (zeige BARD1 Proteine) ubiquitin ligase, which controls the stability of NPM1 (zeige NPM1 Proteine). In turn, decreased NPM1 (zeige NPM1 Proteine) levels led to suppression of p53 (zeige TP53 Proteine) expression, resulting in enhanced cell survival.
All merkel cell carcinoma (MCC (zeige MCC Proteine)) cases with a good outcome expressed pSTAT5B, whereas all MCC (zeige MCC Proteine) cases with a poor outcome did not express pSTAT5B; hence, pSTAT5B expression may be an indicator of positive prognosis in patients with MCC (zeige MCC Proteine).
Instead, we find that STAT5B (zeige STAT5B Proteine) is dominant over STAT5A in CD4 (zeige CD4 Proteine)(+) 'helper' T cells for both effector and regulatory (Treg) responses and, therefore, uniquely necessary for immunological tolerance.
Data indicate that obesity-induced insulin (zeige INS Proteine) resistance and lipotoxicity can be treated with ginsenoside Rg3, which acts though the STAT5-PPAR gamma (zeige PPARG Proteine) pathway in vivo and in vitro.
STAT5a regulates miR (zeige MLXIP Proteine)-135a transcription by binding to both miR (zeige MLXIP Proteine)-135a-1 and miR135a-2 promoter elements
These studies establish the importance of STAT5 in macrophages during ductal morphogenesis in the mammary gland and demonstrate that altering STAT5 function in macrophages can affect the development of tissue-specific disease.
findings show that Stat5 is required for CD103 (zeige ITGAE Proteine)(+) dendritic cell and alveolar macrophage development.These findings demonstrate the critical importance of Stat5 signaling in maintaining lung homeostasis, and underscore the importance of resident macrophages in moderating tissue damage and excess inflammation.
STAT5 target genes such as Oncostatin M (zeige OSM Proteine) were highly expressed in FLT3 (zeige FLT3 Proteine)-ITD(+) myeloid but not in FLT3 (zeige FLT3 Proteine)-ITD(+) lymphoid progenitor cells; lineage-specific STAT5 activation in hematopoietic progenitor cells predicts the FLT3 (zeige FLT3 Proteine)(+)-mediated leukemic phenotype in mice.
findings reveal an essential role for STAT5 in maintaining lipid homeostasis in white adipose tissue and provide a rationale for future studies into the potential of STAT5 manipulation to improve outcomes in metabolic diseases.
deregulation of local signal transducer and activator of transcription 5 signaling augments high fat diet-induced lipid accumulation in both muscle and liver.
Data show that CUZD1 (zeige CUZD1 Proteine) interacts with a complex containing JAK1 (zeige JAK1 Proteine)/JAK2 (zeige JAK2 Proteine) and STAT5, downstream transducers of prolactin (zeige PRL Proteine) signaling in the mammary gland.
There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.
Milk production traits were analyzed for each animal in the first, second, third, and fourth lactation. No genetic variability was found at STAT5A/AvaI locus. At STAT5A/MslI locus, the frequencies of T and C alleles were 0.875 and 0.125, respectively. Significant differences between genotypes were found
Results indicate that SNPs in STAT5A and JAK2 (zeige JAK2 Proteine) genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
The embryonic STAT5A gene is primarily activated by maternal gene products and the most abundant STAT5A expression occurred at the 2-cell stage blastocysts.
INVESTIGATION OF STAT5A, FSHR (zeige FSHR Proteine) AND LHR (zeige LHCGR Proteine) GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS
The Stat5a gene is associated with an increase in lactation of mammary gland epithelial cells.
STAT5A/AvaI polymorphism seems to be a promising indirect marker to improve milk production traits in cattle.
Associations between reproduction and milk traits, and polymorphisms at the STAT5A and FGF2 (zeige FGF2 Proteine) gene loci, were found with STAT5A polymorphism for age at first calving (suggestive effect; P =0.077) and lactation milk yield (significant effect; P<0.05).
Base sequence variation in STAT5A-noncoding region was studied.
The association of fertilization rate with STAT5A polymorphisms was evaluated in ocytes. Associations were found for 6 and 2 SNP. 5 SNP showed associations with both embryonic survival and fertilization rate compared with 1 SNP.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.
mammary gland factor STAT5A
, mammary gland factor
, signal transducer and activator of transcription 5
, STAT5A, Mammary Gland Factor
, signal transducer and activator of transcription 5A
, signal transducer and activator of transcription 5A-like
, signal transducer and activator of transcription 5B
, signal transducer and activator of transcription 5B L homeolog