STAT5A Proteine (STAT5A)

Signal Transducer and Activator of Transcription 5A Proteine (STAT5A)
Auf finden Sie aktuell 11 Signal Transducer and Activator of Transcription 5A (STAT5A) Proteine von 7 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen STAT5A Antikörper (497) und STAT5A Kits (43) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 594 STAT5A Produkte verfügbar.
AA959963, MGF, Stat5, STAT5A, STAT5A/MGF, STATA5
alle Proteine anzeigen Gen GeneID UniProt
STAT5A 6776 P42229
STAT5A 20850 P42230
STAT5A 24918 Q62771

Weitere Synonyme anzeigen

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Weitere Proteine zu STAT5A Interaktionspartnern

Human Signal Transducer and Activator of Transcription 5A (STAT5A) Interaktionspartner

  1. Molecular interactions of EphA4 (zeige EPHA4 Proteine), growth hormone receptor (zeige GHR Proteine), Jak2 (zeige JAK2 Proteine), and STAT5B (zeige STAT5B Proteine) have been described.

  2. High STAT5 phosphorylation is associated with systemic lupus erythematosus.

  3. NPM1 (zeige NPM1 Proteine) downregulation by P-STAT5 is mediated by impairing the BRCA1-BARD1 (zeige BARD1 Proteine) ubiquitin ligase, which controls the stability of NPM1 (zeige NPM1 Proteine). In turn, decreased NPM1 (zeige NPM1 Proteine) levels led to suppression of p53 (zeige TP53 Proteine) expression, resulting in enhanced cell survival.

  4. All merkel cell carcinoma (MCC (zeige MCC Proteine)) cases with a good outcome expressed pSTAT5B, whereas all MCC (zeige MCC Proteine) cases with a poor outcome did not express pSTAT5B; hence, pSTAT5B expression may be an indicator of positive prognosis in patients with MCC (zeige MCC Proteine).

  5. High STAT5A expression is associated with B-lymphoblastic lymphoma with inflammation.

  6. Results provide evidence that HDAC6 (zeige HDAC6 Proteine) could regulate HMGN2 (zeige HMGN2 Proteine) acetylation levels and binding to Stat5a-responsive promoters, and therefore, Stat5a transcriptional activity in breast cancer cells.

  7. Sustained STAT5 transcription factor (STAT5) phosphorylation is necessary to induce long-term interleukin 2 receptor subunit alpha (CD25 (zeige IL2RA Proteine)) expression in T lymphocytes.

  8. BCR/ABL (zeige ABL1 Proteine) positively regulates the expression of EZH2 (zeige EZH2 Proteine) via STAT5 signaling.

  9. these results demonstrate that the oncogenic signal transducer and activator of transcription 5/Akt (zeige AKT1 Proteine) pathway is a cellular target for indole-3-carbinol in chronic myeloid leukemia (zeige BCL11A Proteine) cells. Thus, this clinically tested natural compound can be a potential candidate in the treatment of chronic myeloid leukemia (zeige BCL11A Proteine) following confirmation with clinical studies

  10. elucidate a novel mechanism whereby the linker histone H1 (zeige H1F0 Proteine) prevents STAT5 binding at promoter DNA, and the PRL (zeige PRL Proteine)-induced dissociation of H1 mediated by HMGN2 (zeige HMGN2 Proteine) is necessary to allow full STAT5 recruitment and promote the biological effects of PRL (zeige PRL Proteine) signaling

Mouse (Murine) Signal Transducer and Activator of Transcription 5A (STAT5A) Interaktionspartner

  1. STAT5 target genes such as Oncostatin M (zeige OSM Proteine) were highly expressed in FLT3 (zeige FLT3 Proteine)-ITD(+) myeloid but not in FLT3 (zeige FLT3 Proteine)-ITD(+) lymphoid progenitor cells; lineage-specific STAT5 activation in hematopoietic progenitor cells predicts the FLT3 (zeige FLT3 Proteine)(+)-mediated leukemic phenotype in mice.

  2. findings reveal an essential role for STAT5 in maintaining lipid homeostasis in white adipose tissue and provide a rationale for future studies into the potential of STAT5 manipulation to improve outcomes in metabolic diseases.

  3. deregulation of local signal transducer and activator of transcription 5 signaling augments high fat diet-induced lipid accumulation in both muscle and liver.

  4. Data show that CUZD1 (zeige CUZD1 Proteine) interacts with a complex containing JAK1 (zeige JAK1 Proteine)/JAK2 (zeige JAK2 Proteine) and STAT5, downstream transducers of prolactin (zeige PRL Proteine) signaling in the mammary gland.

  5. The study describes an interaction network of STAT5a/LSD1 (zeige KDM1A Proteine)/HDAC3 (zeige HDAC3 Proteine) and a dual function of LSD1 (zeige KDM1A Proteine)/HDAC3 (zeige HDAC3 Proteine) on STAT5a-dependent transcription, defined by protein-protein interactions, genomic binding localization/affinity and motifs.

  6. this study shows that lipoxin A4 protects against LPS (zeige TLR4 Proteine)-induced sepsis by promoting the generation and migration of splenic innate response activator B cells, and the underlying molecular mechanism may be related to STAT5 activation

  7. Study showed that suppression of STAT3 (zeige STAT3 Proteine), STAT5, and STAT6 (zeige STAT6 Proteine) and overexpression of the proapoptotic factor STAT1 (zeige STAT1 Proteine), which provides p53 (zeige TP53 Proteine)-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 (zeige ERBB2 Proteine) tyrosine kinase receptor (zeige KDR Proteine) overexpression promotes neuronal survival through activation of STAT (zeige STAT1 Proteine)-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1 (zeige STAT1 Proteine)

  8. Mechanistically, RL negatively regulates Stat5 phosphorylation and Elf5 (zeige ELF5 Proteine) expression at the onset of lactogenesis. Continuous RL exposure leads to the expansion of basal and bipotent cells in WT and MMTV-RANK acini. Overall, we demonstrate that enhanced Rank signaling impairs secretory differentiation during pregnancy by inhibition of the prolactin (zeige PRL Proteine)/p-Stat5 pathway.

  9. Bcl6 (zeige BCL6 Proteine) promoted T follicular helper cell differentiation through antagonizing IL-7R / STAT5a axis.

  10. constitutive STAT5 binding to c-Myc (zeige MYC Proteine) super-enhancer might contribute to BRD2 (zeige BRD2 Proteine) maintenance and thus allow sustained expression of c-Myc (zeige MYC Proteine) in Ba/F3 cells transformed by STAT5-1*6.

Pig (Porcine) Signal Transducer and Activator of Transcription 5A (STAT5A) Interaktionspartner

Cow (Bovine) Signal Transducer and Activator of Transcription 5A (STAT5A) Interaktionspartner

  1. There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.

  2. Milk production traits were analyzed for each animal in the first, second, third, and fourth lactation. No genetic variability was found at STAT5A/AvaI locus. At STAT5A/MslI locus, the frequencies of T and C alleles were 0.875 and 0.125, respectively. Significant differences between genotypes were found

  3. Results indicate that SNPs in STAT5A and JAK2 (zeige JAK2 Proteine) genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.

  4. The embryonic STAT5A gene is primarily activated by maternal gene products and the most abundant STAT5A expression occurred at the 2-cell stage blastocysts.


  6. The Stat5a gene is associated with an increase in lactation of mammary gland epithelial cells.

  7. STAT5A/AvaI polymorphism seems to be a promising indirect marker to improve milk production traits in cattle.

  8. Associations between reproduction and milk traits, and polymorphisms at the STAT5A and FGF2 (zeige FGF2 Proteine) gene loci, were found with STAT5A polymorphism for age at first calving (suggestive effect; P =0.077) and lactation milk yield (significant effect; P<0.05).

  9. Base sequence variation in STAT5A-noncoding region was studied.

  10. The association of fertilization rate with STAT5A polymorphisms was evaluated in ocytes. Associations were found for 6 and 2 SNP. 5 SNP showed associations with both embryonic survival and fertilization rate compared with 1 SNP.

STAT5A Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Alternative names and synonyms associated with STAT5A

  • signal transducer and activator of transcription 5A (STAT5A)
  • signal transducer and activator of transcription 5A (Stat5a)
  • signal transducer and activator of transcription 5A-like (LOC100348518)
  • signal transducer and activator of transcription 5B (STAT5B)
  • AA959963 Protein
  • MGF Protein
  • Stat5 Protein
  • STAT5A Protein
  • STAT5A/MGF Protein
  • STATA5 Protein

Bezeichner auf Proteinebene für STAT5A

signal transducer and activator of transcription 5A , signal transducer and activator of transcription 5A-like , mammary gland factor STAT5A , mammary gland factor , signal transducer and activator of transcription 5 , STAT5A, Mammary Gland Factor , transcription factor STAT5B

100052904 Equus caballus
454681 Pan troglodytes
574129 Macaca mulatta
100461695 Pongo abelii
6776 Homo sapiens
20850 Mus musculus
24918 Rattus norvegicus
490968 Canis lupus familiaris
397550 Sus scrofa
282375 Bos taurus
100716811 Cavia porcellus
443419 Ovis aries
100348518 Oryctolagus cuniculus
6777 Homo sapiens
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