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Human SOCS2 Protein expressed in Wheat germ - ABIN1320927
Sen, Peng, Woods, Wistuba, Bell, El-Naggar, Lai, Johnson: STAT5A-mediated SOCS2 expression regulates Jak2 and STAT3 activity following c-Src inhibition in head and neck squamous carcinoma. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012
The upregulation of SOCS-1 (zeige SOCS1 Proteine) and SOCS-2 by cortisol may be playing a key role in suppressing cytokine signaling and the associated inflammatory response.
this study shows that IL-7 (zeige IL7 Proteine) induces the expression of SOCS2 through the JAK (zeige JAK3 Proteine)/STAT-5 (zeige STAT5A Proteine) pathway and that SOCS2 interacts with CD127 (zeige IL7R Proteine) in early endosomes and direct the receptor complex to the proteasome for degradation
Overexpression of SOCS2 inverted these phenotypes generated by hsv2-miR (zeige MLXIP Proteine)-H9-5p, indicating the potential roles of SOCS2 in Hsv2-miR (zeige MLXIP Proteine)-H9-5p-driven metastasis in lung cancers. The results highlighted that Hsv2-miR (zeige MLXIP Proteine)-H9-5p regulated and contributed to bone metastasis of lung cancers. We proposed that Hsv2-miR (zeige MLXIP Proteine)-H9-5p could be used as a potential target in lung cancer therapy
Overexpression of SOCS-2 is associated with hepatocellular carcinoma.
focus on SOCS2 and review its biological function as well as its implication in pathological processes
SOCS2 may improve outcome of TBI (zeige TBPL1 Proteine) in mice by regulating aspects of the neuroinflammatory response
This study showed that there was significantly increased levels of SOCS-2 mRNA in elderly and Alzheimer's disease brains.
crystals of SOCS2 in complex with its adaptor proteins, Elongin C (zeige TCEB1 Proteine) and Elongin B (zeige TCEB2 Proteine), underwent a change in crystallographic parameters when treated with dimethyl sulfoxide during soaking experiments.
miR (zeige MLXIP Proteine)-101 functions as a growth-suppressive miRNA in H. pylori related GC, and that its suppressive effects are mediated mainly by repressing SOCS2 expression.
our study indicates that high SOCS2 expression is associated with poor survival in pediatric AML (zeige RUNX1 Proteine).
This study shows that over-expression of SOCS2 reduces the psychostimulant effects of amphetamine, enhances PPI, and alters mesolimbic dopaminergic activity.
Our data show that absence of SOCS2 turns cardiomyocytes unresponsive to LIF (zeige LIF Proteine)-induced [Ca(2 (zeige CA2 Proteine)+)] raise, indicating that endogenous levels of SOCS2 are crucial for full activation of LIF (zeige LIF Proteine) signaling in the heart.
Knockdown of SOCS2 makes mice less sensitive to multiple low dose streptozotocin.
Study provides an insight into the role of SOCS2 in modulating the immune response to Bovine herpesvirus 5 [BoHV-5]infection.
Data (including data from studies in knockout mice) suggest Socs2 regulates liver regeneration rate after partial hepatectomy, Ghr (growth hormone receptor (zeige GHR Proteine)) level via ubiquitination/proteolysis, and serum Igf1 (insulin-like growth factor-1 (zeige IGF1 Proteine)) level.
GH appears to act directly on the metatarsals of Socs2(-/-) mice, promoting growth via a mechanism that is independent of IGF-1 (zeige IGF1 Proteine).
comparison of murine wt and Socs2(-/-) HSC (zeige FUT1 Proteine) gene expression in response to 5-FU revealed a significant overlap with the molecular programs that correlate with SOCS2 expression in leukemias, particularly with the oncogenic pathways
Studies indicate the critical role of suppressor of cytokine signaling 2 (SOCS2) in ontrolling the local growth hormone (GH (zeige GH1 Proteine)) anabolic bone effects.
Taken together, our observations indicated that SOCS2 could suppress myotube formation, act as an anti-regulator of mitochondria biogenesis via inhibiting p38 MAPK (zeige MAPK14 Proteine) signal pathway.
SOCS2 immunoprecipitates with TrkA (zeige NTRK1 Proteine) and a juxtamembrane motif of TrkA (zeige NTRK1 Proteine) is required for this interaction. Over-expression of SOCS2 in PC12 Tet-On cells increased total and surface TrkA (zeige NTRK1 Proteine) expression. SOCS2 regulates neurite outgrowth.
Results show that CISH (zeige CISH Proteine) has no non-redundant functions in beta cell proliferation or glucose homeostasis during pregnancy in mice. Socs2 might compensate for the loss of Cish (zeige CISH Proteine) during pregnancy.
hepatic growth hormone receptor (zeige GHR Proteine) and suppressor of cytokine signaling (SOCS (zeige CISH Proteine))2 messenger RNA expression appeared to be promptly and sensitively regulated by increased estradiol levels before ovulation of dairy heifers
relative amount of suppressors of cytokine signaling-2 (SOCS-2)messenger RNA increased after parturition
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants.
suppressor of cytokine signaling-2
, suppressor of cytokine signaling 2
, suppressor of cytokine signaling 2 variant 1
, STAT induced STAT inhibitor-2
, STAT-induced STAT inhibitor 2
, STAT-induced STAT inhibitor-2
, cytokine-inducible SH2 protein 2
, cytokine inducible SH2-containing protein 2
, suppressor of cytokine signalling 2