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The Xenopus PIAS (zeige PIAS1 Proteine) genes are expressed throughout early development and have overlapping and distinct expression patterns, with, for example, high levels of PIAS2 in the notochord.
A direct interaction between Pold2 (zeige POLD2 Proteine) and PIAS2 was confirmed by direct yeast two-hybrid.
Interaction of protein inhibitor of activated STAT 2 (PIAS2) with receptor of activated C kinase 1, RACK1 (zeige GNB2L1 Proteine).
regulates interleukin-7 receptor (zeige IL7R Proteine) signaling at early commitment stages of B cell differentiation
a transcriptional cofactor for TFII-I (zeige GTF2I Proteine)
Miz-1 (zeige ZBTB17 Proteine) trans-actiates Nramp1 (zeige SLC11A1 Proteine) in mice
Results show that Miz1 is required for early embryonic development during gastrulation.
Miz-1 (zeige ZBTB17 Proteine) has a role in inducing apoptosis along with MAGE-A4 (zeige MAGEA4 Proteine)
study provides the first line of evidence that PIASxbeta is indispensable for osteoblast differentiation and matrix mineralization, and that this signaling molecule is located between Runx2 (zeige RUNX2 Proteine) and osterix (zeige SP7 Proteine).
strategy for the purification of tethered POZ domains that form forced heterodimers is described, and crystal structures of the heterodimeric POZ domains of Miz1 (zeige ZBTB17 Proteine)/BCL6 (zeige BCL6 Proteine) and of Miz1 (zeige ZBTB17 Proteine)/NAC1 (zeige NACC1 Proteine) are reported
the expression of SENP8 (zeige SENP8 Proteine), SAE1 (zeige SAE1 Proteine), PIAS1 (zeige PIAS1 Proteine), PIAS2 and ZMIZ1 is deregulated in the majority of PTC (zeige F9 Proteine) tissues, likely contributing to the PTC (zeige F9 Proteine) phenotype.
UXT (zeige UXT Proteine) is a binding protein of PIAS2, and interaction between PIAS2 and UXT (zeige UXT Proteine) may be important for the transcriptional activation of AR.
PIASxalpha is a novel SUMO E3 ligase for PTEN, and it positively regulates PTEN protein level in tumor suppression.
These findings suggest that SUMO-1 (zeige SUMO1 Proteine) modification of MDA5 (zeige IFIH1 Proteine) possibly via PIAS2beta may play a role in the MDA5 (zeige IFIH1 Proteine)-mediated interferon (zeige IFNA Proteine) response to viral infections.
PIASx may function as a co-repressor of Stat4 (zeige STAT4 Proteine)
Required for upregulation of a large group of genes in response to DNA damage, a function that is regulated by c-Myc (zeige MYC Proteine), but not by 14-3-3eta and represses the expression of many genes
the repressive properties of PIASxalpha/ARIP3 require its physical interaction with FLI-1 (zeige FLI1 Proteine), identifying PIASxalpha as a novel corepressor of FLI-1 (zeige FLI1 Proteine)
findings show that Epstein-Barr virus Rta (zeige RBM9 Proteine) interacts and colocalizes with PIASxalpha and PIASxbeta in the nucleus; these interactions seem to enhance Rta (zeige RBM9 Proteine) sumoylation
PIASxalpha acts as a key signal integrator that permits different responses from the same transcription factor, depending on the signaling pathway that is activated.
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1.
protein inhibitor of activated STAT, 2
, protein inhibitor of activated STAT X
, protein inhibitor of activated STAT2
, E3 SUMO-protein ligase PIAS2
, E3 SUMO-protein ligase PIAS2-like
, e3 SUMO-protein ligase PIAS2-like
, DAB2-interacting protein
, Msx-interacting-zinc finger
, androgen receptor-interacting protein 3
, msx-interacting zinc finger protein
, protein inhibitor of activated STAT x
, zinc finger, MIZ-type containing 4
, msx-interacting-zinc finger protein