LIF Proteine (LIF)

Leukemia Inhibitory Factor Proteine (LIF)
Auf finden Sie aktuell 98 Leukemia Inhibitory Factor (LIF) Proteine von 20 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen LIF Antikörper (181) und LIF Kits (82) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 378 LIF Produkte verfügbar.
A230075M04Rik, AW061234, CDF, DIA, HILDA, LIF, MLPLI
alle Proteine anzeigen Gen GeneID UniProt
LIF 16878 P09056
LIF 3976 P15018
LIF 60584  

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Am meisten referenzierte LIF Proteine

  1. Human LIF Protein expressed in Escherichia coli (E. coli) - ABIN2666883 : Souza, Palmqvist, Lundberg, Lundgren, Hänström, Souza, Conaway, Lerner: Interleukin-4 and interleukin-13 inhibit the expression of leukemia inhibitory factor and interleukin-11 in fibroblasts. in Molecular immunology 2012 (PubMed)
    Zeige alle 6 Referenzen für 2666883

  2. Mouse (Murine) LIF Protein expressed in Escherichia coli (E. coli) - ABIN2666519 : Metcalfe: LIF in the regulation of T-cell fate and as a potential therapeutic. in Genes and immunity 2011 (PubMed)
    Zeige alle 5 Referenzen für 2666519

  3. Human LIF Protein expressed in Escherichia coli (E. coli) - ABIN2018195 : Yu, Kastin, Pan: TNF reduces LIF endocytosis despite increasing NFkappaB-mediated gp130 expression. in Journal of cellular physiology 2007 (PubMed)
    Zeige alle 2 Referenzen für 2018195

  4. Human LIF Protein expressed in Escherichia coli (E. coli) - ABIN667245 : Gillett, Lowe, Lu, Chan, Ferrara: Leukemia inhibitory factor expression in human carotid plaques: possible mechanism for inhibition of large vessel endothelial regrowth. in Growth factors (Chur, Switzerland) 1994 (PubMed)
    Zeige alle 2 Referenzen für 667245

  5. Human LIF Protein expressed in Human Cells - ABIN2006356 : Salas, García-Barchino, Labiano, Shugay, Pérez-Encinas, Quinteiro, García-Delgado, Vizmanos, Novo: LIF, a Novel STAT5-Regulated Gene, Is Aberrantly Expressed in Myeloproliferative Neoplasms. in Genes & cancer 2011 (PubMed)

Weitere Proteine zu LIF Interaktionspartnern

Mouse (Murine) Leukemia Inhibitory Factor (LIF) Interaktionspartner

  1. lung epithelium, specifically alveolar type II cells, is the predominant site of LIF transcript induction in pneumonic mouse lungs.

  2. LIF/STAT3 (zeige STAT3 Proteine) and MEK (zeige MDK Proteine)/ERK (zeige EPHB2 Proteine) signaling in naive embryonic stem cell pluripotency, is reported.

  3. uterine expression of the LIFR (zeige LIFR Proteine) is essential for embryo implantation; this further define the components of the LIF signaling pathway necessary for effective implantation.

  4. LIF stimulates, in part, stem cell-derived cardiomyocyte regeneration by activating cardiac stem or precursor cells.

  5. Our data show that absence of SOCS2 (zeige SOCS2 Proteine) turns cardiomyocytes unresponsive to LIF-induced [Ca(2 (zeige CA2 Proteine)+)] raise, indicating that endogenous levels of SOCS2 (zeige SOCS2 Proteine) are crucial for full activation of LIF signaling in the heart.

  6. OSM (mOSM) signals mainly via an OSM receptor (OSMR)-gp130 heterodimer and binds with only very low affinity to mLIFR.

  7. These results establish that Bcl3 (zeige BCL3 Proteine) positively regulates pluripotency genes and thus shed light on the mechanism of Bcl3 (zeige BCL3 Proteine) as a downstream molecule of LIF/STAT3 (zeige STAT3 Proteine) signaling in pluripotency maintenance.

  8. The role of LIF in acetylcholine synthesis via the STAT3 (zeige STAT3 Proteine), PI3 (zeige PI3 Proteine) kinases, or cAMP-protein kinase A pathways, are reported.

  9. Either LIF or EGF (zeige EGF Proteine) is needed during development of pre-implantation embryo.

  10. Our data suggest that LIF plays an important role in placentation in vivo and the maintenance of healthy pregnancy.

Human Leukemia Inhibitory Factor (LIF) Interaktionspartner

  1. Data suggest a 216-nucleotide proximal cis (zeige CISH Proteine)-element in LIF mRNA exhibits mRNA destabilizing potential; on exposure to carcinogen PMA (phorbol-12-myristate-13-acetate), this cis (zeige CISH Proteine)-element exhibits mRNA stabilizing activity. PMA induces nucleo-cytoplasmic translocation of both nucleolin (zeige NCL Proteine) and PCBP1 (zeige PCBP1 Proteine), 2 trans-acting factors that bind to and stabilize LIF mRNA. [LIF = leukemia inhibitory factor; PCBP1 (zeige PCBP1 Proteine) = poly(rC) binding protein 1 (zeige PCBP1 Proteine)]

  2. Leukemia inhibitory factor (LIF) - STAT3 (zeige STAT3 Proteine) transcription factor (STAT3 (zeige STAT3 Proteine)) signaling pathway is systemically dysregulated in in the endometrium of patients with recurrent/repeated implantation failure (RIFE).

  3. Endometrial expression of LIF and LIFR (zeige LIFR Proteine) is significantly reduced in the epithelial cells of infertile women.

  4. LIF SNP T/G (rs929271) seems to be a susceptibility biomarker capable of predicting implantation efficiency and pregnancy outcomes.

  5. Overexpression of LIF promotes Epithelial-mesenchymal transition and results in cancer.

  6. This review discusses the role of LIF and the recent analysis of its action on the uterine LE in regulating endometrial receptivity and implantation.

  7. Women with dormant genital tuberculosis were found to have decreased endometrial LIF-STAT3 (zeige STAT3 Proteine) signaling.

  8. Data show that leukemia inhibitory factor (LIF) signaling promote chemoresistance in cholangiocarcinoma by up-regulating myeloid cell factor-1 (Mcl-1 (zeige MCL1 Proteine)) via phosphatidylinositol 3-kinase (PI3K (zeige PIK3CA Proteine))/c-akt (zeige AKT1 Proteine) protein (AKT (zeige AKT1 Proteine))-dependent pathway.

  9. Despite common signal transduction mechanisms (JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine), MAPK (zeige MAPK1 Proteine) and PI3K (zeige PIK3CA Proteine)) LIF can have paradoxically opposite effects in different cell types including stimulating or inhibiting each of cell proliferation, differentiation and survival.

  10. Taken together, we firstly demonstrate that LIF enhances the adhesion of trophoblastic cells to endometrial cells by up-regulating expression of integrin heterodimer alphaVbeta3 and alphaVbeta5.

Pig (Porcine) Leukemia Inhibitory Factor (LIF) Interaktionspartner

  1. Cell cycle synchronization of leukemia inhibitory factor (LIF)-dependent porcine-induced pluripotent stem cells and the generation of cloned embryos.

  2. Studied effect of recombinant porcine leukemia inhibitory factor on in vitro maturation of porcine oocytes; p-STAT3 (zeige STAT3 Proteine) markedly increased in both cumulus cells and oocytes cultured in pLIF (zeige FTH1 Proteine)-supplemented media.

  3. LIF and IL-6 (zeige IL6 Proteine) are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.

  4. Reprogramming pig fetal fibroblasts reveals a functional LIF signaling pathway.

  5. favorable effect on litter size in pigs of the A allele for a SNP within the LIF gene

  6. LIF (Leukemia inhibitory factor) mRNA was elevated in stented segments of coronary arteries; vascular smooth muscle cell proliferation was inhibited by LIF treatment in an in-vitro model of atherosclerosis

  7. study found significant association of two diallelic polymorphisms in the porcine genes for leukaemia inhibitory factor (LIF) and retinol-binding protein 4 (RBP4 (zeige RBP4 Proteine)) with number of piglets born alive (NBA) in two German pig lines

Cow (Bovine) Leukemia Inhibitory Factor (LIF) Interaktionspartner

  1. Studied the effects of leukemia inhibitory factor (LIF) on bovine oocyte maturation and early embryo development in vitro.

  2. results suggest that leukemia inhibitory factor and macrophage-colony stimulating factor (zeige CSF2 Proteine) are produced in the endometrium and may play different roles in early and mid-pregnancy

LIF Protein Überblick

Protein Überblick

The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with LIF

  • leukemia inhibitory factor (Lif)
  • leukemia inhibitory factor (LIF)
  • leukemia inhibitory factor (cholinergic differentiation factor) (LIF)
  • leukemia inhibitory factor receptor (Lifr)
  • A230075M04Rik Protein
  • AW061234 Protein
  • CDF Protein
  • DIA Protein
  • HILDA Protein
  • LIF Protein
  • MLPLI Protein

Bezeichner auf Proteinebene für LIF

d factor , differentiation-stimulating factor , D factor , cholinergic differentiation factor , differentiation inhibitory activity , differentiation-inducing factor , hepatocyte-stimulating factor III , human interleukin in DA cells , melanoma-derived LPL inhibitor , leukemia inhibitory factor (cholinergic differentiation factor) , cholinergic neuronal differentiation factor , bLIF , leukemia inhibitory factor , D-factor/LIF receptor , LIF receptor , LIF-R , leukemia inhibitory factor receptor alpha chain , soluble differentiation-stimulating factor receptor

16878 Mus musculus
3976 Homo sapiens
427718 Gallus gallus
60584 Rattus norvegicus
399503 Sus scrofa
100713602 Cavia porcellus
101110180 Ovis aries
280840 Bos taurus
403449 Canis lupus familiaris
16880 Mus musculus
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