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Human LIF Protein expressed in Escherichia coli (E. coli) - ABIN2018195
Yu, Kastin, Pan: TNF reduces LIF endocytosis despite increasing NFkappaB-mediated gp130 expression. in Journal of cellular physiology 2007
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Authors demonstrate heterozygous novel or rare LIFR (zeige LIFR Proteine) mutations in 3.3% of CAKUT patients, and provide evidence that Lifr (zeige LIFR Proteine) deficiency and deactivating LIFR (zeige LIFR Proteine) mutations cause highly similar anomalies of the urogenital tract in mice and humans.
lung epithelium, specifically alveolar type II cells, is the predominant site of LIF transcript induction in pneumonic mouse lungs.
LIF/STAT3 (zeige STAT3 Proteine) and MEK (zeige MDK Proteine)/ERK (zeige EPHB2 Proteine) signaling in naive embryonic stem cell pluripotency, is reported.
uterine expression of the LIFR (zeige LIFR Proteine) is essential for embryo implantation; this further define the components of the LIF signaling pathway necessary for effective implantation.
LIF stimulates, in part, stem cell-derived cardiomyocyte regeneration by activating cardiac stem or precursor cells.
Our data show that absence of SOCS2 (zeige SOCS2 Proteine) turns cardiomyocytes unresponsive to LIF-induced [Ca(2 (zeige CA2 Proteine)+)] raise, indicating that endogenous levels of SOCS2 (zeige SOCS2 Proteine) are crucial for full activation of LIF signaling in the heart.
OSM (mOSM) signals mainly via an OSM receptor (OSMR)-gp130 heterodimer and binds with only very low affinity to mLIFR.
These results establish that Bcl3 (zeige BCL3 Proteine) positively regulates pluripotency genes and thus shed light on the mechanism of Bcl3 (zeige BCL3 Proteine) as a downstream molecule of LIF/STAT3 (zeige STAT3 Proteine) signaling in pluripotency maintenance.
The role of LIF in acetylcholine synthesis via the STAT3 (zeige STAT3 Proteine), PI3 (zeige PI3 Proteine) kinases, or cAMP-protein kinase A pathways, are reported.
Either LIF or EGF (zeige EGF Proteine) is needed during development of pre-implantation embryo.
These results demonstrate the involvement of PIM (zeige PIM1 Proteine) kinases in LIF-induced regulation in different trophoblastic cell lines which may indicate similar functions in primary cells.
Data suggest a 216-nucleotide proximal cis (zeige CISH Proteine)-element in LIF mRNA exhibits mRNA destabilizing potential; on exposure to carcinogen PMA (phorbol-12-myristate-13-acetate), this cis (zeige CISH Proteine)-element exhibits mRNA stabilizing activity. PMA induces nucleo-cytoplasmic translocation of both nucleolin (zeige NCL Proteine) and PCBP1 (zeige PCBP1 Proteine), 2 trans-acting factors that bind to and stabilize LIF mRNA. [LIF = leukemia inhibitory factor; PCBP1 (zeige PCBP1 Proteine) = poly(rC) binding protein 1 (zeige PCBP1 Proteine)]
Leukemia inhibitory factor (LIF) - STAT3 (zeige STAT3 Proteine) transcription factor (STAT3 (zeige STAT3 Proteine)) signaling pathway is systemically dysregulated in in the endometrium of patients with recurrent/repeated implantation failure (RIFE).
Endometrial expression of LIF and LIFR (zeige LIFR Proteine) is significantly reduced in the epithelial cells of infertile women.
LIF SNP T/G (rs929271) seems to be a susceptibility biomarker capable of predicting implantation efficiency and pregnancy outcomes.
Overexpression of LIF promotes Epithelial-mesenchymal transition and results in cancer.
This review discusses the role of LIF and the recent analysis of its action on the uterine LE in regulating endometrial receptivity and implantation.
Women with dormant genital tuberculosis were found to have decreased endometrial LIF-STAT3 (zeige STAT3 Proteine) signaling.
Data show that leukemia inhibitory factor (LIF) signaling promote chemoresistance in cholangiocarcinoma by up-regulating myeloid cell factor-1 (Mcl-1 (zeige MCL1 Proteine)) via phosphatidylinositol 3-kinase (PI3K (zeige PIK3CA Proteine))/c-akt (zeige AKT1 Proteine) protein (AKT (zeige AKT1 Proteine))-dependent pathway.
Despite common signal transduction mechanisms (JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine), MAPK (zeige MAPK1 Proteine) and PI3K (zeige PIK3CA Proteine)) LIF can have paradoxically opposite effects in different cell types including stimulating or inhibiting each of cell proliferation, differentiation and survival.
Cell cycle synchronization of leukemia inhibitory factor (LIF)-dependent porcine-induced pluripotent stem cells and the generation of cloned embryos.
Studied effect of recombinant porcine leukemia inhibitory factor on in vitro maturation of porcine oocytes; p-STAT3 (zeige STAT3 Proteine) markedly increased in both cumulus cells and oocytes cultured in pLIF (zeige FTH1 Proteine)-supplemented media.
LIF and IL-6 (zeige IL6 Proteine) are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.
Reprogramming pig fetal fibroblasts reveals a functional LIF signaling pathway.
favorable effect on litter size in pigs of the A allele for a SNP within the LIF gene
LIF (Leukemia inhibitory factor) mRNA was elevated in stented segments of coronary arteries; vascular smooth muscle cell proliferation was inhibited by LIF treatment in an in-vitro model of atherosclerosis
study found significant association of two diallelic polymorphisms in the porcine genes for leukaemia inhibitory factor (LIF) and retinol-binding protein 4 (RBP4 (zeige RBP4 Proteine)) with number of piglets born alive (NBA) in two German pig lines
Studied the effects of leukemia inhibitory factor (LIF) on bovine oocyte maturation and early embryo development in vitro.
results suggest that leukemia inhibitory factor and macrophage-colony stimulating factor (zeige CSF2 Proteine) are produced in the endometrium and may play different roles in early and mid-pregnancy
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, differentiation-stimulating factor
, D factor
, cholinergic differentiation factor
, differentiation inhibitory activity
, differentiation-inducing factor
, hepatocyte-stimulating factor III
, human interleukin in DA cells
, melanoma-derived LPL inhibitor
, leukemia inhibitory factor (cholinergic differentiation factor)
, cholinergic neuronal differentiation factor
, leukemia inhibitory factor
, D-factor/LIF receptor
, LIF receptor
, leukemia inhibitory factor receptor alpha chain
, soluble differentiation-stimulating factor receptor