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Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (zeige IFNG Proteine) signal.
Single-nucleotide polymorphism in JAK2 gene is associated with breast cancers.
When transduced into rad chimera mice, 3 human activating JAK2 mutants can differentially couple to selective cytokine receptors EpoR (zeige EPOR Proteine) and GCSFR (zeige CSF3R Proteine) and change the signaling repertoire, revealing the molecular basis for phenotypic differences elicited by JAK2 (V617F) or mutations in exon 12.
inhibition of the H3K27 demethylase (zeige MBD2 Proteine) JMJD3 in naive CD4 (zeige CD4 Proteine) T cells demonstrates how critically important molecules required for T cell differentiation, such as JAK2 and IL12RB2 (zeige IL12RB2 Proteine), are regulated by H3K27me3.
Testing for JAK2 mutations is now included in the World Health Organization (WHO) criteria for the diagnosis of MPN, and in 2011 the oral JAK2 kinase inhibitor ruxolitinib became the first Food and Drug Administration (FDA)-approved drug for the treatment of myelofibrosis.
In our study, there was no genotypic or phenotypic association between the JAK2 rs10758669 variant and UC. Only the (C) allele was identified to increase the risk of a more severe disease progression.
C-CALR (zeige CALR Proteine) in response to Ca2 (zeige CA2 Proteine)+ undergoes conformational changes that trigger its function to export GR from the nucleus, resetting the stress response of normal erythroid cells. Impairment of this function in JAK2V617F-positive erythroid cells maintains EPO-R (zeige EPOR Proteine) signaling in proliferation mode, contributing to erythrocytosis in PV.
BRM (zeige SMARCA2 Proteine) could activate JAK2/STAT3 (zeige STAT3 Proteine) pathway to promote pancreatic cancer growth and chemoresistance.
Regulation of platelet-activating factor-mediated PTP1B activation by a Janus kinase 2/ calpain pathway has been reported.
Multiple myeloma cells over express JAK1 (zeige JAK1 Proteine)/2 and suggest combined chemotherapy with ruxolitinib, bortezomib and lenalidomide to inhibit JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) pathway.
Molecular interactions of EphA4 (zeige EPHA4 Proteine), growth hormone receptor (zeige GHR Proteine), Jak2, and STAT5B (zeige STAT5B Proteine) have been described.
a novel signaling axis that regulates JAK2 in normal and malignant HSPCs and suggest new therapeutic strategies for treating CBL (zeige CBL Proteine)(mut (zeige MUT Proteine)) myeloid malignancies.
In summary, JAK2 functions in a homeostatic capacity in podocytes by facilitating autophagy. It does this by regulating the expression of the transcription factor TFEB (zeige TFEB Proteine) that is necessary for normal autophagic-lysosomal function
these findings demonstrate that expression of Hmga2 cooperates with Jak2(V617F) in the pathogenesis of Mmyelofibrosis.
Study shows that Jak2 with V617F mutation induces murine model for myeloproliferative neoplasm.
results suggest that loss of Ezh2 (zeige EZH2 Proteine) cooperates with Jak2V617F in the development of myelofibrosis in Jak2V617F
JAK2-V617F-expressing mice treated with an Ezh2 (zeige EZH2 Proteine) inhibitor showed higher platelet counts than vehicle controls. Our data support the proposed tumor suppressor function of EZH2 (zeige EZH2 Proteine)
findings demonstrate that clinically relevant doses of the JAK1 (zeige JAK1 Proteine)/2 inhibitor ruxolitinib suppresses the harmful consequences of macrophage overactivation characterizing Hemophagocytic lymphohistiocytosis in 2 murine models.
JAK2 has a role in hepatocarcinogenesis through regulating critical inflammatory pathways
Data show that CUZD1 (zeige CUZD1 Proteine) interacts with a complex containing JAK1 (zeige JAK1 Proteine)/JAK2 and STAT5 (zeige STAT5A Proteine), downstream transducers of prolactin (zeige PRL Proteine) signaling in the mammary gland.
The results showed that AG490 inhibited (p)-JAK2 and RANKL (zeige TNFSF11 Proteine) expression.
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (zeige JAK3 Proteine)-STAT (zeige STAT1 Proteine)-AKT (zeige AKT1 Proteine) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (zeige STAT5A Proteine) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (zeige STAT5A Proteine) and mTOR (zeige FRAP1 Proteine) signaling pathways.
SNPs in JAK2 and STAT5B (zeige STAT5B Proteine) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase