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Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (zeige IFNG Proteine) signal.
Decreased expression of JNK2 (zeige MAPK9 Proteine) in T24 cells conferred resistance to cell death induced by mitomycin C
JAK2(V617F) mutation is associated with myelofibrosis.
the frequencies of mutations from JAK2 wild-type to JAK2V617F and vice versa increased following erythroid differentiation
we report that the recipient and the donor JAK2 46/1 haplotypes are significantly associated with aGvHD grades II-IV in AML (zeige RUNX1 Proteine) patients undergoing allo-HSCT.
our studies suggest that the JAK2(V617F)-bearing ECs form an important component of the myeloproliferative neoplasms vascular niche and contribute to mutant stem/progenitor cell expansion, likely through a critical role of the TPO (zeige THPO Proteine)/MPL (zeige MPL Proteine) signaling axis.
Data show that co-treated with vincristine and XL019, a inhibitor of JAK2 and P-glycoprotein (P-gp), up-regulated expression of p21 and phosphorylated H2A histone family, member X (pH2AX).
dehydrocostus lactone significantly inhibits the phosphorylation expression of Bcr/Abl (zeige ABL1 Proteine), STAT5 (zeige STAT5A Proteine), JAK2, and STAT3 (zeige STAT3 Proteine) and downstream molecules including p-CrkL (zeige CRKL Proteine), Mcl-1 (zeige MCL1 Proteine), Bcl-XL (zeige BCL2L1 Proteine), and Bcl-2 (zeige BCL2 Proteine) proteins in K562 cells.
JAK2V617F mutation influences myeloproliferative neoplasm-associated inflammation with a strong correlation between allele burden and PTX3 (zeige PITX3 Proteine) levels.
TGR5 (zeige GPBAR1 Proteine) exhibits significantly higher expression in NSCLC tumor samples and facilitates the growth and metastasis of NSCLC by activating the JAK2/STAT3 (zeige STAT3 Proteine) signaling pathway.
JAK2V617F mutations were found in 59 patients in the olycythemia vera (zeige IGF2BP3 Proteine) group
After Dox treatment, the protein expression of p-Jak2 and p-Stat3 (zeige STAT3 Proteine) levels was significantly increased in MT(+/+) cardiomyocytes, suggesting that the JAK2/STAT3 (zeige STAT3 Proteine) pathway was partially involved in MT protection against Dox-induced cardiotoxicity
CIS (zeige CISH Proteine) interacted with phosphorylated EpoR (zeige EPOR Proteine) at Y401, which was critical for the activation of STAT5 (zeige STAT5A Proteine) and ERK (zeige EPHB2 Proteine).
Cell volume homeostasis requiring Na+/H+ exchange signaled by JAK2 first becomes prominent during mouse embryonic development at the late one-cell stage.
a novel signaling axis that regulates JAK2 in normal and malignant HSPCs and suggest new therapeutic strategies for treating CBL (zeige CBL Proteine)(mut (zeige MUT Proteine)) myeloid malignancies.
In summary, JAK2 functions in a homeostatic capacity in podocytes by facilitating autophagy. It does this by regulating the expression of the transcription factor TFEB (zeige TFEB Proteine) that is necessary for normal autophagic-lysosomal function
these findings demonstrate that expression of Hmga2 cooperates with Jak2(V617F) in the pathogenesis of Mmyelofibrosis.
Study shows that Jak2 with V617F mutation induces murine model for myeloproliferative neoplasm.
results suggest that loss of Ezh2 (zeige EZH2 Proteine) cooperates with Jak2V617F in the development of myelofibrosis in Jak2V617F
JAK2-V617F-expressing mice treated with an Ezh2 (zeige EZH2 Proteine) inhibitor showed higher platelet counts than vehicle controls. Our data support the proposed tumor suppressor function of EZH2 (zeige EZH2 Proteine)
findings demonstrate that clinically relevant doses of the JAK1 (zeige JAK1 Proteine)/2 inhibitor ruxolitinib suppresses the harmful consequences of macrophage overactivation characterizing Hemophagocytic lymphohistiocytosis in 2 murine models.
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (zeige JAK3 Proteine)-STAT (zeige STAT1 Proteine)-AKT (zeige AKT1 Proteine) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (zeige STAT5A Proteine) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (zeige STAT5A Proteine) and mTOR (zeige FRAP1 Proteine) signaling pathways.
SNPs in JAK2 and STAT5B (zeige STAT5B Proteine) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase