JAK2 Proteine (JAK2)

Bezeichnung:
Janus Kinase 2 Proteine (JAK2)
Auf www.antikoerper-online.de finden Sie aktuell 21 Janus Kinase 2 (JAK2) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen JAK2 Antikörper (264) und JAK2 Kits (26) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 324 JAK2 Produkte verfügbar.
Synonyme:
AI504024, C81284, Fd17, JAK-2, jak2, JAK2bCA, JTK10, THCYT3
alle Proteine anzeigen Gen GeneID UniProt
JAK2 3717 O60674
JAK2 16452 Q62120
JAK2 24514 Q62689

Weitere Synonyme anzeigen

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Weitere Proteine zu JAK2 Interaktionspartnern

Zebrafish Janus Kinase 2 (JAK2) Interaktionspartner

  1. Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (zeige IFNG Proteine) signal.

Human Janus Kinase 2 (JAK2) Interaktionspartner

  1. mechanical load upregulates expression of Runx2 (zeige RUNX2 Proteine) gene via potentiation of PC1 (zeige PCSK1 Proteine)-JAK2/STAT3 (zeige STAT3 Proteine) signaling axis, culminating to possibly control osteoblastic differentiation and ultimately bone formation.

  2. blocking the ERRalpha (zeige ESRRA Proteine)-controlled mitochondrial program largely inhibits the PLA2R1 (zeige PLA2R1 Proteine)-induced tumor-suppressive response. Together, our data document ERRalpha (zeige ESRRA Proteine) and its mitochondrial program as downstream effectors of the PLA2R1 (zeige PLA2R1 Proteine)-JAK2 pathway leading to oncosuppression.

  3. JAK2 was overexpressed in Epstein Barr virus-associated gastric adenocarcinoma.

  4. As marrow histology in this murine model of myeloproliferation reveals a preferentially perivascular localization of JAK2(V617F)-mutant megakaryocytes and an increased marrow sinusoid vascular density

  5. mutated FLT3 (zeige FLT3 Proteine)-ITD and JAK2 augment reactive oxygen species production and homologous recombination, shifting the cellular milieu toward illegitimate recombination events.

  6. Germ line JAK2 mutations E846D and R1063H are associated with hereditary erythrocytosis with megakaryocytic atypia.

  7. Data suggest that ruxolitinib treatment for up to 4 years provides progressive reductions in Janus kinase 2 (JAK2) p.V617F allele burden in patients with polycythemia vera (zeige IGF2BP3 Proteine) (PV).

  8. Mice expressing the human JAK2-N542-E543del (Ex12) showed a strong increase in red blood cell parameters but normal neutrophil and platelet counts, and reduced overall survival. Erythropoiesis was increased in the bone marrow and spleen, with normal megakaryopoiesis and absence of myelofibrosis in histopathology.

  9. data indicate that a low positivity of JAK2 V617F can be seen in MPN (zeige PRSS27 Proteine) as well as reactive conditions

  10. These data indicate that the same germ line variants endow individuals with a predisposition not only to myeloproliferative neoplasms, but also to JAK2 V617F clonal hematopoiesis.

Mouse (Murine) Janus Kinase 2 (JAK2) Interaktionspartner

  1. Study shows that Jak2 with V617F mutation induces murine model for myeloproliferative neoplasm.

  2. results suggest that loss of Ezh2 (zeige EZH2 Proteine) cooperates with Jak2V617F in the development of myelofibrosis in Jak2V617F

  3. JAK2-V617F-expressing mice treated with an Ezh2 (zeige EZH2 Proteine) inhibitor showed higher platelet counts than vehicle controls. Our data support the proposed tumor suppressor function of EZH2 (zeige EZH2 Proteine)

  4. findings demonstrate that clinically relevant doses of the JAK1 (zeige JAK1 Proteine)/2 inhibitor ruxolitinib suppresses the harmful consequences of macrophage overactivation characterizing Hemophagocytic lymphohistiocytosis in 2 murine models.

  5. JAK2 has a role in hepatocarcinogenesis through regulating critical inflammatory pathways

  6. Data show that CUZD1 (zeige CUZD1 Proteine) interacts with a complex containing JAK1 (zeige JAK1 Proteine)/JAK2 and STAT5 (zeige STAT5A Proteine), downstream transducers of prolactin (zeige PRL Proteine) signaling in the mammary gland.

  7. The results showed that AG490 inhibited (p)-JAK2 and RANKL (zeige TNFSF11 Proteine) expression.

  8. these results have revealed that phosphorylation of Tyr (zeige TYR Proteine)-343, Tyr (zeige TYR Proteine)-460, and Tyr (zeige TYR Proteine)-464 in EpoR (zeige EPOR Proteine) underlies JAK2 V617F mutant-induced tumorigenesis.

  9. this study shows that ampelopsin reduces inflammatory response of microglial cells through inhibition of JAK2-STAT3 (zeige STAT3 Proteine) signaling

  10. At the molecular level, administration of liraglutide induced the expression of PDX-1 (zeige PDX1 Proteine), MafA (zeige MAFA Proteine), p-JAK2 and p-Stat3 (zeige STAT3 Proteine) in high-fat diet-induced diabetes model to relatively normal levels.

Pig (Porcine) Janus Kinase 2 (JAK2) Interaktionspartner

  1. nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (zeige JAK3 Proteine)-STAT (zeige STAT1 Proteine)-AKT (zeige AKT1 Proteine) interactions

Cow (Bovine) Janus Kinase 2 (JAK2) Interaktionspartner

  1. Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle

  2. Results indicate that SNPs in STAT5A (zeige STAT5A Proteine) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.

  3. Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (zeige STAT5A Proteine) and mTOR (zeige FRAP1 Proteine) signaling pathways.

  4. SNPs in JAK2 and STAT5B (zeige STAT5B Proteine) are associated with mastitis susceptibility in Chinese Holstein cattle

  5. Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver

JAK2 Protein Überblick

Protein Überblick

This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.

Alternative names and synonyms associated with JAK2

  • Janus kinase 2b (jak2b)
  • Janus kinase 2 (JAK2)
  • Janus kinase 2 (Jak2)
  • tyrosine-protein kinase JAK2-like (LOC100051487)
  • AI504024 Protein
  • C81284 Protein
  • Fd17 Protein
  • JAK-2 Protein
  • jak2 Protein
  • JAK2bCA Protein
  • JTK10 Protein
  • THCYT3 Protein

Bezeichner auf Proteinebene für Janus Kinase 2 Proteine (JAK2)

Jak2b kinase , PTK JAK2b , protein tyrosine kinase JAK2b , tyrosine-protein kinase JAK2 , JAK-2 , Janus kinase 2 (a protein tyrosine kinase) , tyrosine kinase

GENE ID SPEZIES
30298 Danio rerio
3717 Homo sapiens
16452 Mus musculus
24514 Rattus norvegicus
374199 Gallus gallus
484185 Canis lupus familiaris
397201 Sus scrofa
525246 Bos taurus
464979 Pan troglodytes
100172517 Pongo abelii
100051487 Equus caballus
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