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Human IL21 Protein expressed in Escherichia coli (E. coli) - ABIN413500
Yoon, Zhang, Berner, Blom, Choi: Notch ligands expressed by follicular dendritic cells protect germinal center B cells from apoptosis. in Journal of immunology (Baltimore, Md. : 1950) 2009
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Report efficient retroviral vector transduction of primary human natural killer cells that were stimulated by a combination of IL-2 (zeige IL2 Proteine) and engineered K562 cells expressing membrane-bound IL-21 (zeige IL17C Proteine) for cancer immunotherapy.
IL21 (zeige IL17C Proteine) reduction in osteosarcoma patients due to PD-1 (zeige PDCD1 Proteine) and pd-L1 (zeige CD274 Proteine) mediated follicular helper T cells suppression.
this study shows that induction of IL-21 (zeige IL17C Proteine) in T follicular helper cells is an indicator of influenza vaccine response in a HIV-infected pediatric cohort
IL-21 (zeige IL17C Proteine) levels in rheumatoid arthritis synovial fluid were associated with matrix metalloproteinase (MMP)-1 (zeige MMP1 Proteine) and MMP-3 (zeige MMP3 Proteine).
the elevated level of IL-2 (zeige IL2 Proteine)+ and IL-21 (zeige IL17C Proteine)+ T cells and a positive correlation between IL-21 (zeige IL17C Proteine)+ cells with clinical activity index in ulcerative colitis patients may contribute to the pathogenesis of disease.
these results demonstrate a novel function for IL-21 (zeige IL17C Proteine) in tuning NK and CD4 (zeige CD4 Proteine)+ T cell interactions promoting a specific expansion of central memory lymphocytes
Combined IL-21 (zeige IL17C Proteine)-primed polyclonal CTL plus CTLA4 (zeige CTLA4 Proteine) blockade controls refractory metastatic melanoma in a patient
Our work suggests that IL-21 (zeige IL17C Proteine) regulates megakaryocyte development and platelet homeostasis. Thus, IL-21 (zeige IL17C Proteine) may link immune responses to physiological or pathological platelet-dependent processes.
this study shows that Th17/Treg imbalance and increased IL-21 (zeige IL17C Proteine) are associated with liver injury in patients with chronic HBV infection
The findings of the current study indicate an association between IL-21 (zeige IL17C Proteine)+TFH cells and disease activity. IL-21 (zeige IL17C Proteine)+TFH levels may prove to be a useful marker of disease activity in OA patients.
IL-6 (zeige IL6 Proteine) is identified as a master regulator of IL-21 in effector CD8 (zeige CD8A Proteine)(+) T cells.
Our work suggests that IL-21 regulates megakaryocyte development and platelet homeostasis. Thus, IL-21 may link immune responses to physiological or pathological platelet-dependent processes.
we identify novel distal regulatory elements in the mouse Il21 locus and demonstrate a dynamic long-range chromatin interaction between the Il21 promoter and these regulatory elements, which contributes to the regulated expression of IL-21
this study shows that IL-21 acts as a potent inhibitor of a IL-17A (zeige IL17A Proteine)-producing T-cell subset during Mycobacterium bovis Bacillus infection
IL-21 may play an important role in the pathogenesis of SSc (zeige CYP11A1 Proteine) as a Th17 effector cytokine, and IL-21 may induce the differentiation of Th17 cells in the BLM-induced systemic sclerosis mouse model via Il21R (zeige IL21R Proteine).
The data of this study suggested that an increase in astrocyte-derived IL-21 expression in hippocampal subregions following KA-induced seizures may have potent regulatory effects on epileptogenesis.
this study reveals a context-dependent role for IL-21 in sustaining effector phenotype CD8 (zeige CD8A Proteine) T cells and influencing their migratory properties, accumulation, and functions.
Dysregulated development of IL-17 (zeige IL17A Proteine)- and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORgammat.
results demonstrate that, in the setting of lupus-like CD4 (zeige CD4 Proteine) T cell-driven B cell hyperactivity, IL-21 signaling on Ag-specific donor CD8 (zeige CD8A Proteine) T cells is critical for CTL effector maturation whereas a lack of IL-21R (zeige IL21R Proteine) downregulates CTL responses that would otherwise limit B cell hyperactivity and autoantibody production
Gene expression analyses of angioimmunoblastic T-cell lymphoma (AITL), showed that essentially all cases expressed elevated levels of transcripts for IL21, IL21R (zeige IL21R Proteine), and a series of genes associated with TFH cell development and function.
The results revealed that the peak expression of IL6 (zeige IL6 Proteine) and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, interleukin-21 isoform