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anti-Mouse (Murine) IL15 Antikörper:
anti-Human IL15 Antikörper:
anti-Rat (Rattus) IL15 Antikörper:
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Human Monoclonal IL15 Primary Antibody für CyTOF, FACS - ABIN4900390
Marra, Mathew, Grigoriadis, Wu, Kyle-Cezar, Watkins, Rashid, De Rinaldis, Hessey, Gazinska, Hayday, Tutt: IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers. in Cancer research 2014
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Human Monoclonal IL15 Primary Antibody für CyTOF, FACS - ABIN4900389
Ong, Hamid, Travers, Strickland, Al Kerithy, Boguniewicz, Leung: Decreased IL-15 may contribute to elevated IgE and acute inflammation in atopic dermatitis. in Journal of immunology (Baltimore, Md. : 1950) 2001
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Human Monoclonal IL15 Primary Antibody für FACS - ABIN4897621
Anguille, Van Acker, Van den Bergh, Willemen, Goossens, Van Tendeloo, Smits, Berneman, Lion: Interleukin-15 Dendritic Cells Harness NK Cell Cytotoxic Effector Function in a Contact- and IL-15-Dependent Manner. in PLoS ONE 2015
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Human Polyclonal IL15 Primary Antibody für FACS, WB - ABIN4900388
Tejman-Yarden, Zlotnik, Lewis, Etzion, Chaimovitz, Douvdevani: Renal cells express a functional interleukin-15 receptor. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2005
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Human Monoclonal IL15 Primary Antibody für FACS - ABIN4897620
Ferlazzo, Pack, Thomas, Paludan, Schmid, Strowig, Bougras, Muller, Moretta, Münz: Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs. in Proceedings of the National Academy of Sciences of the United States of America 2004
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Human Monoclonal IL15 Primary Antibody für - ABIN1383961
Bernard, Harb, Mortier, Quéméner, Meloen, Vermot-Desroches, Wijdeness, van Dijken, Grötzinger, Slootstra, Plet, Jacques: Identification of an interleukin-15alpha receptor-binding site on human interleukin-15. in The Journal of biological chemistry 2004
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Human Polyclonal IL15 Primary Antibody für Func, IHC (p) - ABIN2474939
Miller: T4 DNA polymerase (gene 43) is required in vivo for repair of gaps in recombinants. in Journal of virology 1975
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Human Polyclonal IL15 Primary Antibody für ELISA, WB - ABIN4324547
Schneider, Mohebiany, Ifergan, Beauseigle, Duquette, Prat, Arbour: B cell-derived IL-15 enhances CD8 T cell cytotoxicity and is increased in multiple sclerosis patients. in Journal of immunology (Baltimore, Md. : 1950) 2011
T cells in chimpanzees infected with human immunodeficiency virus express surface interleukin-15.
CD3 (zeige CD3 Antikörper)(-) CD8 (zeige CD8A Antikörper)(+) NK cells play a vital role in controlling HIV-1 infection by producing high levels of IFN-gamma (zeige IFNG Antikörper), and that IL-15 elicits IFN-gamma (zeige IFNG Antikörper) production in this subpopulation of NK cells in HIV-1-infected chimpanzees. [Il-15, CD8 (zeige CD8A Antikörper) antigen, IFN-gamma (zeige IFNG Antikörper)]
findings extend understanding of the differential modes of action between IL-2 (zeige IL2 Antikörper) and IL-15, and highlight how, although sharing the CD122 (zeige IL2RB Antikörper)/CD132 (zeige IL2RG Antikörper) receptor, they elicit such different immune actions
IL-15 induced by inflammatory signals in response to lymphodepletion drives lymphocyte responses, as memory CD8 (zeige CD8A Antikörper) T cells proliferated in an IL-15-dependent manner.
these findings unveil a role for IL-15 as a critical mediator in defense against systemic candidiasis and hold promise for the design of IL-15-based antifungal immunotherapies.
developmental arrest of Natural killer cells results from a lack of IL-15 availability in the microenvironment.
IL-15 impacts butyrate-producing bacteria and lowers butyrate levels in the absence of overt pathology, which represent events that precede and promote intestinal inflammatory diseases.
endogenous IL-15 does not directly augment the pathogenesis of sepsis but enables the development of septic shock by maintaining NK cell numbers and integrity.
this study shows that IL-15-mediated control of the precursor population affects the development of virus-specific CD8 (zeige CD8A Antikörper)+ T-cell memory
this study shows that unleashed trans-presentation of IL-15 on MyD88 (zeige MYD88 Antikörper)-deficient fibroblastic reticular cells during viral infection fosters the activation of cytotoxic and non-cytotoxic group 1 innate lymphoid cells and accelerates clearance of the virus
this study shows that synergistic enhancement of adaptive immunity by the combination of epigallo catechin gallate and vitamin A or E is dependent on both IL-15 and its receptor
Under steady-state conditions, KLF2 (zeige KLF2 Antikörper)-deficient NK cells alter their expression of homeostatic homing receptors and subsequently undergo apoptosis due to IL-15 starvation.
IL-15 drives bystander activation of CD8 (zeige CD8A Antikörper)+ T cells, which predicts disease progression in untreated HIV-1-infected patients and suggests that elevated IL-15 may also drive CD8 (zeige CD8A Antikörper)+ T cell expansion that is linked to increased morbidity and mortality in treated patients
Sustained virologic response was significantly associated with IL15 rs10833 in chronic hepatitis C patients, treated with pegylated interferon-alpha (zeige IFNA Antikörper) and ribavirin.
IL-15 mRNA and protein levels significantly increased in rhHBcAg stimulation group compared with non-stimulated group.
this work provides evidence that the sushi-IL-15Ralpha/IL-15 fusion protein RLI (zeige ABCE1 Antikörper) enhances antitumor activity of anti-PD-1 (zeige PDCD1 Antikörper) treatment and is a promising approach to stimulate host immunity
These results reveal a novel role of IL-7 (zeige IL7 Antikörper) and IL-15 in maintaining human T cell function, provide an explanation for T cell dysfunction in humanized mice, and have significant implications for in vitro studies with human T cells.
This analysis revealed highly connected functional interaction networks with two candidate genes, IL15 and SEC14L5 highly enriched in networks. Overall, from these results, we concluded that these genes can be recommended as some of the potential targets for Post-Traumatic Stress Disorder.
These data support a potential role for IL-15 in the pathogenesis of HIV-associated immune activation.
Cutaneous T-cell lymphoma (CTCL (zeige TSPYL2 Antikörper)) pathogenesis remains unknown, and there are no curative therapies. Our findings not only demonstrate a critical role for IL15-mediated inflammation in cutaneous T-cell lymphomagenesis, but also uncover a new oncogenic regulatory loop in CTCL (zeige TSPYL2 Antikörper) involving IL15, HDAC1 (zeige HDAC1 Antikörper), HDAC6 (zeige HDAC6 Antikörper), and miR (zeige MLXIP Antikörper)-21 that shows differential sensitivity to isotype-specific HDAC (zeige HDAC3 Antikörper) inhibitors
we provide the first direct evidence that IL-15 is expressed both at the mRNA and protein level in human salivary gland epithelial cells and it is clear that salivary glands from primary Sjogren's syndrome patients showed an intensified epithelial expression of IL-15
Myokine IL-15 regulates the crosstalk of co-cultured porcine skeletal muscle satellite cells and preadipocytes.
results demonstrate that porcine reproductive and respiratory syndrome virus (PRRSV)infection could induce IL-15 production in macrophages/dendritic cells; data further show that upregulation of IL-15 by PRRSV requires PKC (zeige FYN Antikörper) and NF-kappaB (zeige NFKB1 Antikörper) pathways
IFN-gamma (zeige IFNG Antikörper) targets the adipocyte to induce IL-15 expression, thus indicating a possible role for the adipocyte in the regulation of T-cell function and muscle metabolism during the innate immune response
When induced by IFN-gamma (zeige IFNG Antikörper) or other inflammatory mediators, IL-15 may be a significant homeorhetic factor that mobilizes and directs energy away from the adipocyte to other cells during the acute phase of the inflammatory response.
Increased function and survival of IL-15-transduced dendritic cells are mediated by up-regulation of IL-15Ralpha and Bcl-2 (zeige BCL2 Antikörper).
IL 15 generates a dramatic expansion of short-lived memory CD8 (zeige CD8A Antikörper) T cells and natural killer in immunocompetent macaques and has long-term effects on the balance of CD4 (zeige CD4 Antikörper)(+) and CD8 (zeige CD8A Antikörper)(+) T cells.
These data suggest that therapeutic use of IL-15 in the setting of antiretroviral therapy might facilitate specific restoration of the CD4 (zeige CD4 Antikörper) + T cell compartment.
IL-15 secretion significantly correlates with the up-regulated expression of CD4 (zeige CD4 Antikörper) on memory CD4 (zeige CD4 Antikörper) T cells that is associated with increased permissiveness to simian immunodeficiency virus infection.
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.