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Mouse (Murine) IL-13 Protein expressed in Escherichia coli (E. coli) - ABIN1305069
Doherty, Kastelein, Menon, Andrade, Coffman: Modulation of murine macrophage function by IL-13. in Journal of immunology (Baltimore, Md. : 1950) 1994
Show all 3 Pubmed References
Serum IL-5 (zeige IL5 Proteine) and IL-13 are reliable biomarkers for the blood eosinophilia asthma phenotype.
IL-13 suppressed cyp27b1 (zeige CYP27B1 Proteine) expression in CD14 (zeige NDUFA2 Proteine)(+) cells. IL-13 increased expression of miR (zeige MLXIP Proteine)-19a in CD14 (zeige NDUFA2 Proteine)(+) cells. IL-13 suppresses cyp27b1 (zeige CYP27B1 Proteine) expression in peripheral CD14 (zeige NDUFA2 Proteine)(+) cells via up regulating miR (zeige MLXIP Proteine)-19a expression.
Leptin (zeige LEP Proteine) knockdown suppressed MUC5AC production and secretion induced by IL-13 in human bronchial epithelial cells.
demonstrate a strong association between the ratio of Acinetobacter to Proteobacteria and IL-13 production and the probability of IL-13 production after allergen exposure. IL-13 concentrations in serum were also significantly correlated with the diversity of bacterial DNA. Together, these results underscore the relationship between immune responses to allergens and bacterial exposure during perinatal development.
These observations suggest that mechanical stretch may induce an influx of Ca(2 (zeige CA2 Proteine)+) and up-regulation of IL-13 and MMP-9 (zeige MMP9 Proteine) expression in 16HBE cells via activation of TRPC1 (zeige TRPC1 Proteine)
Studies show that bronchoalveolar lavage fluid (BALF) soluble triggering receptor expressed on myeloid cells-1 (zeige TREM1 Proteine) (sTREM-1) levels do not discriminate between mild-to-moderate asthma and chronic obstructive pulmonary disease (COPD (zeige ARCN1 Proteine)), in contrast, the interleukin 6 (IL-6 (zeige IL6 Proteine))/interleukine 13 (IL-13) ratio measured in BALF effectively differentiated these two diseases.
The presented data substantiate the hypothesis that claudin-18 (zeige CLDN18 Proteine) is a central barrier-forming component of tight junctions and show that IL-13 downregulates claudin-18 (zeige CLDN18 Proteine). These data also suggest that the loss of claudin-18 (zeige CLDN18 Proteine) is associated with increased sensitization to aeroantigens and airway responsiveness
IL-12 pretreatment increased TCR-induced IFN-gamma, TNF-alpha, IL-13, IL-4 and IL-10 production. This suggests that prior exposure to IL-12 potentiates the TCR-induced release of a range of cytokines
Studies in colonic T84 cell monolayers revealed that barrier disruption by the colitis-associated Th2-type cytokines, IL-4 (zeige IL4 Proteine) and IL-13, down-regulates matriptase (zeige ST14 Proteine) as well as prostasin (zeige PRSS8 Proteine) through phosphorylation of the transcriptional regulator STAT6 (zeige STAT6 Proteine)
investigated the role of six potentially functional variants of the IL4 (zeige IL4 Proteine), IL13, and IL4R (zeige IL4R Proteine) genes in gastrointestinal cancer; both IL13 rs20541 and rs1800925 were not associated with gastrointestinal cancer risk for any of the genetic models and subgroup analyses [meta-analysis]
Data indicate that interleukin-33 (IL-33 (zeige IL33 Proteine))-induced Interleukin-13 (IL-13) production by type-2 helper T cells (Th2 cells) Is dependent on epidermal growth factor receptor (EGFR (zeige EGFR Proteine)) expression.
this study shows that environmental IL-13 plays a role in conditioning early thymic progenitors lineage choice, which would impact T cell development
IL-4 (zeige IL4 Proteine) and IL-13 are required to effectively polarize macrophages/dendritic cells to an M2a phenotype and to promote recovery from acute kidney injury.
this study shows that ST2 (zeige SULT2A1 Proteine) regulates early IL-13 production in fungus-induced allergic airway inflammation
These observations suggest that IL-4 (zeige IL4 Proteine) and IL-13 likely operate through the Heteroreceptor and influence Th17 cells to convert to Th1 (zeige HAND1 Proteine) cells and to acquire increased sensitivity to suppression, leading to control of immune-mediated CNS inflammation.
MIF (zeige MIF Proteine)-deficient mice have reduced Nippostrongylus brasiliensis burden and mounted an enhanced type 2 immune response, including increased Gata3 (zeige GATA3 Proteine) expression and IL-13 production in the mesenteric lymph nodes
findings suggest that a leukotriene B4 receptor-2-linked cascade plays a pivotal role in LPS/TLR4 (zeige TLR4 Proteine) signaling for IL-13 synthesis in mast cells, thereby potentially exacerbating allergic response.
Study found IL-13 to be critically involved in the development of chemical-induced asthma, as shown by using IL-13 KO mice, and more specifically in the effector phase as confirmed by anti- IL-13 antibody treatment.
these studies show that fibrosis, steatosis, cholestasis, and ductular reaction are simultaneously controlled but distinctly regulated by interleukin-13 signaling
Our data support that impaired clearance of inhaled allergens triggering IL-13 production by multiple cell types in the airways plays an important role in the pathogenesis of type 2 airway inflammation and suggests therapeutic improvement of mucociliary clearance as a novel treatment strategy for children with allergen-induced asthma.
T helper (Th) type 2 cell cytokine IL-13 modulates airway contraction by secreting matrix metalloproteinase-1 (zeige MMP1 Proteine) from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
, T-cell activation protein P600