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Mouse (Murine) IL-13 Protein expressed in Escherichia coli (E. coli) - ABIN1305069
Doherty, Kastelein, Menon, Andrade, Coffman: Modulation of murine macrophage function by IL-13. in Journal of immunology (Baltimore, Md. : 1950) 1994
Show all 3 Pubmed References
Different genotype profiles of IL13 gene seem to influence the clinical pattern of disease expression mainly confined to the upper airways, as rhinitis, or including the lower airways, as asthma
secretion of IL-13 and amphiregulin (zeige AREG Proteine) suggests Intrahepatic Innate lymphoid cells may be recruited to promote resolution and repair and thereby they may contribute to ongoing fibrogenesis in liver disease.
Increased baseline mRNA levels of the Th2-related cytokine IL-13 and the regulatory cytokine IL-10 (zeige IL10 Proteine) predicted a positive food challenge outcome.
These findings demonstrate that NF-kappaB (zeige NFKB1 Proteine)-mediated transcriptional mechanisms are critically involved in the IL-1beta (zeige IL1B Proteine)-mediated IL-17C (zeige IL17C Proteine) induction, and that IL-13 negatively regulates this induction by suppressing NF-kappaB (zeige NFKB1 Proteine)-based transcriptional activation.
These results suggested that IL-13 +1923C/T polymorphism contributed to the development of asthma.
IL13 AA of rs20541 and STAT4 (zeige STAT4 Proteine) TT of rs925847 are potential genomic biomarkers for predicting lower pulmonary function. The administration of high-dose ICSs to asthmatic patients with genetic variants of IL13 AA may inhibit the advancement of airway remodelling. The genetic variants of STAT4 (zeige STAT4 Proteine) TT did not respond to high-dose ICSs.
The diagnostic performance of sputum IL-13 was superior to both sputum eosinophils and FeNO levels for the identification of well-controlled asthma. Sputum IL-13 levels could serve as a useful biomarker for asthma control assessment.
15LO1 inhibition (by short interfering RNA and chemical inhibitor) decreased IL-13-induced forkhead box protein A3 (FOXA3 (zeige FOXA3 Proteine)) expression and enhanced FOXA2 (zeige FOXA2 Proteine) expression. These changes were associated with reductions in both mucin 5AC and periostin (zeige POSTN Proteine).
Clarithromycin suppressed IL-13-induced periostin (zeige POSTN Proteine) production in human lung fibroblasts, in part by inhibiting STAT6 (zeige STAT6 Proteine) phosphorylation. This suggests a novel mechanism of the immunomodulatory effect of clarithromycin in asthmatic airway inflammation and fibrosis.
Simvastatin reversed IL-13-suppressed adenosine deaminase (zeige ADA Proteine) activity, leading to the down-regulation of adenosine signaling and inhibition osteopontin (zeige SPP1 Proteine) expression through the direct inhibition of IL-13-activated STAT6 (zeige STAT6 Proteine) pathway in COPD (zeige ARCN1 Proteine).
Data indicate that interleukin-33 (IL-33 (zeige IL33 Proteine))-induced Interleukin-13 (IL-13) production by type-2 helper T cells (Th2 cells) Is dependent on epidermal growth factor receptor (EGFR (zeige EGFR Proteine)) expression.
this study shows that environmental IL-13 plays a role in conditioning early thymic progenitors lineage choice, which would impact T cell development
IL-4 (zeige IL4 Proteine) and IL-13 are required to effectively polarize macrophages/dendritic cells to an M2a phenotype and to promote recovery from acute kidney injury.
this study shows that ST2 (zeige SULT2A1 Proteine) regulates early IL-13 production in fungus-induced allergic airway inflammation
These observations suggest that IL-4 (zeige IL4 Proteine) and IL-13 likely operate through the Heteroreceptor and influence Th17 cells to convert to Th1 (zeige HAND1 Proteine) cells and to acquire increased sensitivity to suppression, leading to control of immune-mediated CNS inflammation.
MIF (zeige MIF Proteine)-deficient mice have reduced Nippostrongylus brasiliensis burden and mounted an enhanced type 2 immune response, including increased Gata3 (zeige GATA3 Proteine) expression and IL-13 production in the mesenteric lymph nodes
findings suggest that a leukotriene B4 receptor-2-linked cascade plays a pivotal role in LPS/TLR4 (zeige TLR4 Proteine) signaling for IL-13 synthesis in mast cells, thereby potentially exacerbating allergic response.
Study found IL-13 to be critically involved in the development of chemical-induced asthma, as shown by using IL-13 KO mice, and more specifically in the effector phase as confirmed by anti- IL-13 antibody treatment.
these studies show that fibrosis, steatosis, cholestasis, and ductular reaction are simultaneously controlled but distinctly regulated by interleukin-13 signaling
Our data support that impaired clearance of inhaled allergens triggering IL-13 production by multiple cell types in the airways plays an important role in the pathogenesis of type 2 airway inflammation and suggests therapeutic improvement of mucociliary clearance as a novel treatment strategy for children with allergen-induced asthma.
T helper (Th) type 2 cell cytokine IL-13 modulates airway contraction by secreting matrix metalloproteinase-1 (zeige MMP1 Proteine) from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
, T-cell activation protein P600