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either JC1 or DS1 C/EBP site is sufficient to mediate IFN beta-induced down-regulation of SIV long terminal repeat activity and virus replication in macrophages
Hepatitis A virus protein 2B suppresses beta interferon (zeige IFNA Proteine) (IFN) gene transcription by interfering with IFN regulatory factor 3 activation.
BVDV2-E significantly increased IFN-beta activity compared to BVDV2-wt.
The data confirm the involvement of EHMT2 (zeige EHMT2 Proteine) in the epigenetic regulation of IFN-b and demonstrate the activation of a general antiviral state after EHMT2 (zeige EHMT2 Proteine) inhibition.
The authors provide evidence that ICP27 protein encoded by bovine herpesvirus type 1, a viral early protein that shuttles between the nucleus and cytoplasm inhibits transcriptional activity of two bovine IFN-beta gene promoters (IFN-beta1 and IFN-beta3).
The authors demonstrate that bovine herpesvirus 1 bICP0 effectively inhibits bovine IFN-beta promoter activity and induces IRF3 (zeige IRF3 Proteine) degradation.
These studies provide evidence that virus infection differentially stimulates expression of the three bovine IFN-beta genes.
recombinant bovine respiratory syncytial virus lacking the NS proteins, and those lacking NS2 in particular, are strong inducers of IFN-alpha (zeige IFNA Proteine)/beta in bovine nasal fibroblasts and bronchoalveolar macrophages.
The effect of topical TREX1 (zeige TREX1 Proteine) knockdown and local interferon (zeige IFNA Proteine) production on HIV transmission in human cervicovaginal explants and humanized mice, is reported.
The TBK1 (zeige TBK1 Proteine) Y179A mutant failed to rescue type I IFN production by virally infected RAW264.7 macrophages deficient in TBK1 (zeige TBK1 Proteine).
this study shows that poly I:C treated PAR-1 (zeige MARK2 Proteine)-/- mice given the thrombin (zeige F2 Proteine) inhibitor dabigatran etexilate exhibited less IFNbeta and CXCL10 (zeige CXCL10 Proteine) expression in the spleen and plasma
The data demonstrate that an atypical TLR7 (zeige TLR7 Proteine) signaling pathway contributes to type interferon-beta expression during Y. pestis infection and suggest that the TLR7 (zeige TLR7 Proteine)-driven type I IFN response plays an important role in determining the outcome of plague.
Long-term exposure to atmospheric particulates, PM2.5 up-regulated H3K4 and H3K9 methylation in IL-6 (zeige IL6 Proteine) and IFN-beta promoter regions through down-regulating Kdm6a (zeige KDM6A Proteine) expression. The results suggest that short-term exposure to PM2.5 significantly enhances the survival rate of influenza A-contaminated mice, while long-term PM2.5 inhalation lowers the capacity of pulmonary macrophages to secrete IL-6 (zeige IL6 Proteine) and IFN-beta.
Extracellular ATP reduces the replication of VSV, Newcastle disease virus, murine leukemia virus and HSV in vivo and in vitro through the P2X7 receptor (zeige P2RX7 Proteine); ATP increases IFN-beta expression. Mechanistically, ATP facilitates IFN-beta secretion through P38 (zeige CRK Proteine)/JNK (zeige MAPK8 Proteine)/ATF-2 (zeige ATF2 Proteine) signaling pathways, which are crucial in promoting antiviral immunity.
study reports that mitochondrial antiviral signaling protein (MAVS (zeige MAVS Proteine)), -mediated IFN-alpha (zeige IFNA Proteine)/beta production and IFNAR (zeige IFNAR1 Proteine) signaling are required for alloimmune responses to the human K1 Ag in a murine model of inflammation-induced alloimmunization
study identifies a novel role for RIPK1 (zeige RIPK1 Proteine) and RIPK3 (zeige RIPK3 Proteine), a pair of homologous serine/threonine kinases previously implicated in the regulation of necroptosis and pathologic tissue injury, in directing IFN-beta production in macrophages
results suggest that, in addition to its well-known signaling activity, IFN-beta may be directly antimicrobial and be part of a growing family of cytokines and chemokines, called kinocidins, that also have antimicrobial properties.
results show that resistance to HSV-1 in the trigeminal ganglia during acute infection is conferred in part by STING and IFN-alpha (zeige IFNA Proteine)/beta signaling in both bone marrow-derived and -resident cells, which coalesce to support a robust HSV-1-specific CD8 (zeige CD8A Proteine)(+) T cell response
this study shows that the IFN-beta/STAT1 (zeige STAT1 Proteine) pathway is dysregulated in inflammatory bowel disease
results demonstrate that Sphingosine 1-phosphate lyase (SPL (zeige SGPL1 Proteine)) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon (zeige IKBKE Proteine) and SPL (zeige SGPL1 Proteine), which provides a mechanistic understanding of the pro-IFN activity of SPL (zeige SGPL1 Proteine)
This study demonstrates a novel pathway for elevated IFNbeta signaling in SLE that is not dependent on stimulation by immune complexes but rather is cell intrinsic and critically mediated by IFNbeta and MAVS (zeige MAVS Proteine).
G45R mutation of NS1 (zeige PTPN11 Proteine) slightly decreased NS1 (zeige PTPN11 Proteine) binding to dsRNA but did not interfere with its suppression of RIG-I (zeige DDX58 Proteine)-mediated type I IFN production.
Upon influenza virus infection, DPF2 dysregulated IFN-beta induction and expression of cytokines/chemokines and antiviral proteins. This study provides evidence that influenza virus utilizes DPF2 to escape host innate immunity.
Overexpression of PKV VP3 blocked IFN-beta-induced activation of the STAT1 (zeige STAT1 Proteine)/STAT2 (zeige STAT2 Proteine)/IRF9 (zeige IRF9 Proteine) promoter in a dose-dependent manner.
Data suggest that EV71 infection in enterocytes does not inhibit phosphorylation of STAT1 (zeige STAT1 Proteine)/2 induced by IFN-beta, but p-STAT1 (zeige STAT1 Proteine)/2 transport into the nucleus is significantly blocked; EV71 infection in enterocytes down-regulates expression of KPNA1 (zeige KPNA1 Proteine) and induces degradation of cellular KPNA1 (zeige KPNA1 Proteine) via caspase-3 (zeige CASP3 Proteine). [EV17 = Enterovirus 71]
This study reveals that decreased induction of both PKR (zeige PKLR Proteine) and p300 (zeige EP300 Proteine) proteins contribute to impaired induction of IFN-beta in Chronic obstructive pulmonary disease primary bronchial epithelial cells upon influenza infection.
Nuclear export of NSP1alpha of porcine reproductive and respiratory syndrome virus was necessary for its ability for IFN beta inhibition.
Porcine deltacoronavirus nsp5 (zeige SPECC1 Proteine), the 3C-like protease, inhibits interferon-beta production through the cleavage of NEMO (zeige IKBKG Proteine).
Highly pathogenic Porcine reproductive and respiratory syndrome virus modulates Interferon-beta expression mainly through attenuating IRF-3 (zeige IRF3 Proteine) phosphorylation.
Porcine epidemic diarrhea virus nsp1 inhibited the IFN-beta and IRF3 (zeige IRF3 Proteine) promoter activities.
poIFIT3 plays a significant role in the clearance of swine influenza virus in pigs and potentiates IFN-beta production.
DDX41 (zeige DDX41 Proteine) is involved in the dsDNA- and dsDNA-virus-mediated type IFN-beta signaling pathway in porcine kidney cells.
VIral NS4 (zeige SOS1 Proteine) protein antagonizes beta interferon (zeige IFNA Proteine) expression by targeting the NF-kappaB (zeige NFKB1 Proteine) essential modulator.
Swine IFN-beta promotes genetic mutation of porcine reproductive and respiratory syndrome virus.
Expression of LSm14A (zeige LSM14A Proteine) in HEK293 or Marc (zeige CCL7 Proteine)-145 cells enhanced activities of IFN-beta and NF-kappaB (zeige NFKB1 Proteine) promoters, induced IFN-beta transcription, and potentiated IFN-beta promoter activation, indicating that LSm14A (zeige LSM14A Proteine) is a potential signal molecule (zeige WNT4 Proteine) in the IFN-beta pathway.
Overall, data provide evidence for the possible role of PI3K in the activation of the transcription of IFN-alpha (zeige IFNA Proteine)/beta by PRRSV; study concludes that PRRSV inhibits the induction of IFN-alpha (zeige IFNA Proteine) in monocyte-derived dendritic cells by as yet undefined post-transcriptional mechanisms.
suppresses the growth of rat glioma cells
, fibroblast interferon
, interferon beta
, interferon, beta 1
, interferon beta-1
, interferon beta 1
, interferon type B
, interferon, beta 1, fibroblast
, IFN-alpha/beta receptor 2
, interferon alpha/beta receptor 2
, interferon, beta; receptor
, interferon-alpha/beta receptor 2
, interferon-alpha/beta receptor beta chain
, type I interferon receptor 2