IFNB1 Proteine (IFNB1)

Bezeichnung:
Interferon, beta 1, Fibroblast Proteine (IFNB1)
Auf www.antikoerper-online.de finden Sie aktuell 67 Interferon, beta 1, Fibroblast (IFNB1) Proteine von 16 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen IFNB1 Antikörper (374) und IFNB1 Kits (102) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 558 IFNB1 Produkte verfügbar.
Synonyme:
IFB, IFF, IFN-beta, IFN-R, IFN-R-2, IFNb, IFNBR
alle Proteine anzeigen Gen GeneID UniProt
IFNB1 15977 P01575
IFNB1 24481 P70499
IFNB1 3456 P01574

Weitere Synonyme anzeigen

IFNB1 Proteine (IFNB1) nach Spezies

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Am meisten referenzierte IFNB1 Proteine

  1. Human IFNB1 Protein expressed in CHO Cells - ABIN2003285 : Takaoka, Hayakawa, Yanai, Stoiber, Negishi, Kikuchi, Sasaki, Imai, Shibue, Honda, Taniguchi: Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence. in Nature 2003 (PubMed)
    Zeige alle 4 Referenzen für 2003285

  2. Human IFNB1 Protein expressed in Human Cells - ABIN2003282 : Improta, Pine: Susceptibility to virus infection is determined by a Stat-mediated response to the autocrine effect of virus-induced type I interferon. in Cytokine 1997 (PubMed)
    Zeige alle 4 Referenzen für 2003282

  3. Mouse (Murine) IFNB1 Protein expressed in HEK-293 - ABIN2666971 : Nagarajan: Induction and function of IFNβ during viral and bacterial infection. in Critical reviews in immunology 2012 (PubMed)
    Zeige alle 3 Referenzen für 2666971

  4. Mouse (Murine) IFNB1 Protein expressed in Escherichia coli (E. coli) - ABIN666768 : Fierlbeck, dHoedt, Stroebel, Stutte, Bogenschütz, Rassner: [Intralesional therapy of melanoma metastases with recombinant interferon-beta]. in Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete 1992 (PubMed)
    Zeige alle 2 Referenzen für 666768

  5. Human IFNB1 Protein expressed in Escherichia coli (E. coli) - ABIN1047212 : Lawn, Adelman, Franke, Houck, Gross, Najarian, Goeddel: Human fibroblast interferon gene lacks introns. in Nucleic acids research 1981 (PubMed)
    Zeige alle 2 Referenzen für 1047212

  6. Mouse (Murine) IFNB1 Protein expressed in Human Cells - ABIN2008198 : Biron, Nguyen, Pien: Innate immune responses to LCMV infections: natural killer cells and cytokines. in Current topics in microbiology and immunology 2002 (PubMed)

Weitere Proteine zu IFNB1 Interaktionspartnern

Rhesus Monkey Interferon, beta 1, Fibroblast (IFNB1) Interaktionspartner

  1. either JC1 or DS1 C/EBP site is sufficient to mediate IFN beta-induced down-regulation of SIV long terminal repeat activity and virus replication in macrophages

  2. Hepatitis A virus protein 2B suppresses beta interferon (zeige IFNA Proteine) (IFN) gene transcription by interfering with IFN regulatory factor 3 activation.

Cow (Bovine) Interferon, beta 1, Fibroblast (IFNB1) Interaktionspartner

  1. BVDV2-E significantly increased IFN-beta activity compared to BVDV2-wt.

  2. The data confirm the involvement of EHMT2 (zeige EHMT2 Proteine) in the epigenetic regulation of IFN-b and demonstrate the activation of a general antiviral state after EHMT2 (zeige EHMT2 Proteine) inhibition.

  3. The authors provide evidence that ICP27 protein encoded by bovine herpesvirus type 1, a viral early protein that shuttles between the nucleus and cytoplasm inhibits transcriptional activity of two bovine IFN-beta gene promoters (IFN-beta1 and IFN-beta3).

  4. The authors demonstrate that bovine herpesvirus 1 bICP0 effectively inhibits bovine IFN-beta promoter activity and induces IRF3 (zeige IRF3 Proteine) degradation.

  5. These studies provide evidence that virus infection differentially stimulates expression of the three bovine IFN-beta genes.

  6. recombinant bovine respiratory syncytial virus lacking the NS proteins, and those lacking NS2 in particular, are strong inducers of IFN-alpha (zeige IFNA Proteine)/beta in bovine nasal fibroblasts and bronchoalveolar macrophages.

Mouse (Murine) Interferon, beta 1, Fibroblast (IFNB1) Interaktionspartner

  1. study identifies a novel role for RIPK1 (zeige RIPK1 Proteine) and RIPK3 (zeige RIPK3 Proteine), a pair of homologous serine/threonine kinases previously implicated in the regulation of necroptosis and pathologic tissue injury, in directing IFN-beta production in macrophages

  2. results suggest that, in addition to its well-known signaling activity, IFN-beta may be directly antimicrobial and be part of a growing family of cytokines and chemokines, called kinocidins, that also have antimicrobial properties.

  3. results show that resistance to HSV-1 in the trigeminal ganglia during acute infection is conferred in part by STING and IFN-alpha (zeige IFNA Proteine)/beta signaling in both bone marrow-derived and -resident cells, which coalesce to support a robust HSV-1-specific CD8 (zeige CD8A Proteine)(+) T cell response

  4. RIPK3 (zeige RIPK3 Proteine) regulates type I IFN both transcriptionally, by interacting with MAVS (zeige MAVS Proteine) and limiting RIPK1 (zeige RIPK1 Proteine) interaction with MAVS (zeige MAVS Proteine), and post-transcriptionally.

  5. neddylation contributes to HSV-1-induced early phase IFN-beta production.

  6. Rubicon (zeige KIAA0226 Proteine) specifically interacts with the interferon (zeige IFNA Proteine) regulatory factor (IRF (zeige TRIM63 Proteine)) association domain (IAD) of IRF3 (zeige IRF3 Proteine), and this interaction leads to inhibition of the dimerization of IRF3 (zeige IRF3 Proteine), which negatively regulates interferon (zeige IFNA Proteine)-mediated antiviral response.

  7. Translation arrest is further demonstrated to be key for anti-viral response by acting synergistically with MAVS (zeige MAVS Proteine) activation to amplify TBK1 (zeige TBK1 Proteine) signaling and IFN-beta mRNA transcription, while GADD34 (zeige PPP1R15A Proteine)-dependent protein synthesis recovery contributes to the heterogeneous expression of interferon (zeige IFNA Proteine) observed in dsRNA-activated cells.

  8. The authors report that Raf kinase inhibitory protein (RKIP (zeige PEBP1 Proteine)) is essential for TBK1 (zeige TBK1 Proteine) activation and type I interferon (zeige IFNA Proteine) production triggered by viral infection.

  9. this study shows that paracrine type I IFN can profoundly enhance innate recognition and TLR2-dependent transcriptional responses to Francisella tularensis infection upstream of its role in inflammasome regulation in primary murine peritoneal macrophages but not murine bone marrow-derived macrophages

  10. STAT2 (zeige STAT2 Proteine) recruits USP18 (zeige USP18 Proteine) to the type I IFN receptor subunit IFNAR2 (zeige IFNAR2 Proteine) via its constitutive membrane-distal STAT2 (zeige STAT2 Proteine)-binding site.

Human Interferon, beta 1, Fibroblast (IFNB1) Interaktionspartner

  1. results demonstrate that Sphingosine 1-phosphate lyase (SPL (zeige SGPL1 Proteine)) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon (zeige IKBKE Proteine) and SPL (zeige SGPL1 Proteine), which provides a mechanistic understanding of the pro-IFN activity of SPL (zeige SGPL1 Proteine)

  2. results suggest that, in addition to its well-known signaling activity, IFN-beta may be directly antimicrobial and be part of a growing family of cytokines and chemokines, called kinocidins, that also have antimicrobial properties.

  3. This study demonstrates a novel pathway for elevated IFNbeta signaling in SLE that is not dependent on stimulation by immune complexes but rather is cell intrinsic and critically mediated by IFNbeta and MAVS (zeige MAVS Proteine).

  4. G45R mutation of NS1 (zeige PTPN11 Proteine) slightly decreased NS1 (zeige PTPN11 Proteine) binding to dsRNA but did not interfere with its suppression of RIG-I (zeige DDX58 Proteine)-mediated type I IFN production.

  5. Upon influenza virus infection, DPF2 dysregulated IFN-beta induction and expression of cytokines/chemokines and antiviral proteins. This study provides evidence that influenza virus utilizes DPF2 to escape host innate immunity.

  6. Overexpression of PKV VP3 blocked IFN-beta-induced activation of the STAT1 (zeige STAT1 Proteine)/STAT2 (zeige STAT2 Proteine)/IRF9 (zeige IRF9 Proteine) promoter in a dose-dependent manner.

  7. Data suggest that EV71 infection in enterocytes does not inhibit phosphorylation of STAT1 (zeige STAT1 Proteine)/2 induced by IFN-beta, but p-STAT1 (zeige STAT1 Proteine)/2 transport into the nucleus is significantly blocked; EV71 infection in enterocytes down-regulates expression of KPNA1 (zeige KPNA1 Proteine) and induces degradation of cellular KPNA1 (zeige KPNA1 Proteine) via caspase-3 (zeige CASP3 Proteine). [EV17 = Enterovirus 71]

  8. This study reveals that decreased induction of both PKR (zeige PKLR Proteine) and p300 (zeige EP300 Proteine) proteins contribute to impaired induction of IFN-beta in Chronic obstructive pulmonary disease primary bronchial epithelial cells upon influenza infection.

  9. Together, these results suggest that RSV infection of MSCs alters their immune regulatory function by upregulating IFN-b and IDO (zeige IDO1 Proteine), affecting immune cell proliferation, which may account for the lack of protective RSV immunity and for chronicity of RSV-associated lung diseases such as asthma and COPD (zeige ARCN1 Proteine).

  10. ArfGAP domain-containing protein 2 (ADAP2 (zeige ADAP2 Proteine)) is identified as a key novel scaffolding protein that integrates different modules of the RIG-I (zeige DDX58 Proteine) pathway, located at distinct subcellular locations, and mediates cellular antiviral type I interferon (zeige IFNA Proteine) production.

Pig (Porcine) Interferon, beta 1, Fibroblast (IFNB1) Interaktionspartner

  1. Nuclear export of NSP1alpha of porcine reproductive and respiratory syndrome virus was necessary for its ability for IFN beta inhibition.

  2. Porcine deltacoronavirus nsp5 (zeige SPECC1 Proteine), the 3C-like protease, inhibits interferon-beta production through the cleavage of NEMO (zeige IKBKG Proteine).

  3. Highly pathogenic Porcine reproductive and respiratory syndrome virus modulates Interferon-beta expression mainly through attenuating IRF-3 (zeige IRF3 Proteine) phosphorylation.

  4. Porcine epidemic diarrhea virus nsp1 inhibited the IFN-beta and IRF3 (zeige IRF3 Proteine) promoter activities.

  5. poIFIT3 plays a significant role in the clearance of swine influenza virus in pigs and potentiates IFN-beta production.

  6. DDX41 (zeige DDX41 Proteine) is involved in the dsDNA- and dsDNA-virus-mediated type IFN-beta signaling pathway in porcine kidney cells.

  7. VIral NS4 (zeige SOS1 Proteine) protein antagonizes beta interferon (zeige IFNA Proteine) expression by targeting the NF-kappaB (zeige NFKB1 Proteine) essential modulator.

  8. Swine IFN-beta promotes genetic mutation of porcine reproductive and respiratory syndrome virus.

  9. Expression of LSm14A (zeige LSM14A Proteine) in HEK293 or Marc (zeige CCL7 Proteine)-145 cells enhanced activities of IFN-beta and NF-kappaB (zeige NFKB1 Proteine) promoters, induced IFN-beta transcription, and potentiated IFN-beta promoter activation, indicating that LSm14A (zeige LSM14A Proteine) is a potential signal molecule (zeige WNT4 Proteine) in the IFN-beta pathway.

  10. Overall, data provide evidence for the possible role of PI3K in the activation of the transcription of IFN-alpha (zeige IFNA Proteine)/beta by PRRSV; study concludes that PRRSV inhibits the induction of IFN-alpha (zeige IFNA Proteine) in monocyte-derived dendritic cells by as yet undefined post-transcriptional mechanisms.

IFNB1 Protein Überblick

Protein Überblick

suppresses the growth of rat glioma cells

Alternative names and synonyms associated with IFNB1

  • interferon, beta 1, fibroblast (IFNB1)
  • interferon, beta 1, fibroblast (LOC100342931)
  • interferon (alpha, beta and omega) receptor 2 (IFNAR2)
  • interferon beta 1, fibroblast (Ifnb1)
  • interferon, beta 1, fibroblast (IFNB)
  • IFB Protein
  • IFF Protein
  • IFN-beta Protein
  • IFN-R Protein
  • IFN-R-2 Protein
  • IFNb Protein
  • IFNBR Protein

Bezeichner auf Proteinebene für IFNB1

interferon beta , interferon beta 1 , interferon, beta 1, fibroblast , IFN-alpha-REC , IFN-alpha/beta receptor 2 , interferon alpha/beta receptor 2 , interferon, beta; receptor , interferon-alpha/beta receptor 2 , interferon-alpha/beta receptor beta chain , type I interferon receptor 2 , IFN-beta , interferon, beta 1 , fibroblast interferon , interferon type B , interferon-beta , interferon beta-1

GENE ID SPEZIES
711414 Macaca mulatta
100342931 Oryctolagus cuniculus
282258 Bos taurus
15977 Mus musculus
24481 Rattus norvegicus
3456 Homo sapiens
554219 Gallus gallus
445459 Sus scrofa
493849 Felis catus
100052545 Equus caballus
481558 Canis lupus familiaris
281845 Bos taurus
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