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Mouse (Murine) IFNA2 Protein expressed in Human Cells - ABIN2007923
Xiao, Xiao, Xu, Wang, Chen, Liu, Li, Shi, Nie, Li, Wu, Liu, Ren, Guleng: Exome sequencing identifies novel compound heterozygous IFNA4 and IFNA10 mutations as a cause of impaired function in Crohn's disease patients. in Scientific reports 2015
IFNa (zeige IFNA Proteine) and IFNc show similar antiviral activities and ability to induce antiviral genes in lymphoid tissues.
Data indicate that the combination of AAV2.IL-4 (zeige IL4 Proteine) and AAV2.IFN-alpha (zeige IFNA Proteine) was not significantly different as compared to AAV2.IL-4 (zeige IL4 Proteine) alone.
Infecting virus and the target cell type dictate the extent and signature of inducible IFN-alpha2 gene expression.
Mutation of the IFNAR-1 (zeige IFNAR1 Proteine) receptor binding site of human IFN-alpha2 generates type I IFN competitive antagonists.
produced in vitro and in vivo in response to noncytopathic bovine viral diarrhea virus in lymph nodes cells expressing the myeloid markers CD14 (zeige CD14 Proteine), CD11b (zeige ITGAM Proteine), and CD172a (zeige SIRPA Proteine)
Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 (zeige STAT1 Proteine) and, to a lesser extent, STAT2 (zeige STAT2 Proteine).
Interferon-alpha (zeige IFNA Proteine)-induced CD100 (zeige SEMA4D Proteine) expression on naive CD8 (zeige CD8A Proteine)(+) T cells enhances antiviral responses to hepatitis C infection through CD72 (zeige CD72 Proteine) signal transduction.
Tumor-associated M2 macrophages in mycosis fungoides acquire immunomodulatory function on exposure to IFN-alpha2a and IFN-gamma (zeige IFNG Proteine).
Increase in serum IFNA2 is associated with adenoma.
Data suggest IFNA2 binding to extracellular domain of IFN receptors IFNAR1 (zeige IFNAR1 Proteine) or IFNAR2 (zeige IFNAR2 Proteine) promotes proximity between intracellular domains; signaling depends on duration of activation and affinity of binding rather than specific conformational changes.
Report biased expression of human interferon alpha-2b and Escherichia coli methionine amino peptidase genes under control of single promoter in E. coli.
interferon alpha-2b gene mutations were identified among brain tumor patients; highest percentage of frameshift mutations was identified; patients were found to be under environmental stress from contaminated drinking water and from local gamma radiations
PPARalpha (zeige PPARA Proteine) activation by an agonist WY-14643 could potentiate IFN-alpha (zeige IFNA Proteine) responses, reverse IFN-alpha (zeige IFNA Proteine) refractoriness, and enhance viral eradication in hepatocytes.
The chronic use of low dose of radiations by occupational workers has a significant correlation with mutational effects on interferon alpha 2b gene, further evident by depressed interferon alpha (zeige IFNA Proteine) levels in serum.
IFN-beta (zeige IFNB1 Proteine) was significantly more effective than IFNA2 in protecting human head and neck squamous cell carcinoma lines from oncolysis by vesicular stomatitis.
The structure, mechanism of action and biological activities of IFNalpha2. [Review]
This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold.
, interferon alpha 2
, interferon alpha family, gene 2
, interferon alpha A
, IFN-alpha 2
, interferon-alpha 2
, alpha-2a interferon
, interferon alpha 2a
, interferon alpha 2b
, leIF A