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Mouse (Murine) EPO Protein expressed in Escherichia coli (E. coli) - ABIN1305139
JACOBSON, GOLDWASSER, FRIED, PLZAK: Role of the kidney in erythropoiesis. in Nature 1957
Show all 6 Pubmed References
Human EPO Protein expressed in Wheat germ - ABIN1352975
Zhang, Wang, Wang, Shi, Deng, Fu: rhEPO/EPO discrimination with ultrasensitive electrochemical biosensor based on sandwich-type nano-Au/ZnO sol-gel/nano-Au signal amplification. in Biosensors & bioelectronics 2013
Data show that erythropoietin (EPO) mRNA was upregulated in the lung, from the metamorphic climax (stage 60) onward.
EPO dependent regulation pathway of FGF23 (zeige FGF23 Proteine) gene expression
Fetal plasma EPO concentrations are selectively increased in monochorionic twin pregnancies with intrauterine growth restriction.
SYK (zeige SYK Proteine) mediates the actions of EPO and GM-CSF (zeige CSF2 Proteine) and coordinates with TGF-beta (zeige TGFB1 Proteine) in erythropoiesis.
this study shows that EPO is involved in the pathogenesis of sepsis-induced acute kidney injury
Erythropoietin is superior to the standard prognostic scores in predicting 28-day mortality in patients with acute-on-chronic liver failure.
EPO levels were also found correlated positively with heme, TNF-alpha (zeige TNF Proteine), IL-10 (zeige IL10 Proteine), IP-10 (zeige CXCL10 Proteine) and MCP-1 (zeige CCL2 Proteine) during cerebral malaria.
CK1delta enhances EPO secretion from liver cancer cells under hypoxia by modifying HIF-2alpha (zeige EPAS1 Proteine) and promoting its nuclear accumulation.
Three single nucleotide polymorphisms are associated with increased risk of diabetic retinopathy in a Chinese Han population.
Pharmacokinetic animal studies revealed strongly 15.6-fold plasma half-life extension for the PASylated EPO (83.16 +/- 13.28 h) in comparison to epoetin alpha (8.5 +/- 2.4 h) and darbepoetin alpha (25.3 +/- 2.2h).
Secreted MIR122 reached the kidney and reduced expression of erythropoietin, contributing to inflammation-induced anemia.
Data indicated the possible involvement of Jak2 (zeige JAK2 Proteine)/STAT3 (zeige STAT3 Proteine)/STAT6 (zeige STAT6 Proteine) pathway in the augmentation of EPO on M2 polarization. These results improved the understanding of the immunoregulatory capacity of EPO on macrophages, which might optimize the therapeutic modalities of EPO.
The lack of effect of erythropoietin on hepcidin (zeige HAMP Proteine) expression in mask mice can not be explained by changes in erythroferrone synthesis, as splenic erythroferrone content increased after erythropoietin administration in both C57BL/6 and mask mice.
EPO expression in myoblasts and myotubes is increased by hypoxia and exercise
these findings define a cis (zeige CISH Proteine)-regulatory enhancer network for Epo signaling during erythropoiesis, and provide the framework for future studies involving the interplay of epigenetics and Epo signaling.
FOXD1 (zeige FOXD1 Proteine) lineage renal interstitial cells consist of distinct subpopulations that differ in their responsiveness to Phd2 (zeige EGLN1 Proteine) inactivation and thus regulation of HIF-2 activity and EPO production under hypoxia or conditions of pharmacologic or genetic PHD (zeige PDC Proteine) inactivation.
This study suggests a possible role of EPO in embryonic endodermal development and a new agent for directing the differentiation into endodermal lineages like pancreatic beta-cells.
Smad1 (zeige SMAD1 Proteine) and Smad5 (zeige SMAD5 Proteine) have overlapping functions to govern hepcidin (zeige HAMP Proteine) transcription. Moreover, erythropoietin and erythroferrone target Smad1 (zeige SMAD1 Proteine)/5 signaling and require Smad1 (zeige SMAD1 Proteine)/5 to suppress hepcidin (zeige HAMP Proteine) expression.
EPO role in the glucose homeostasis, thermogenesis and endocrine function of classical brown adipose tissue
Epo transcription in brain pericytes was HIF-2 dependent and cocontrolled by PHD2 (zeige EGLN1 Proteine) and PHD3 (zeige EGLN3 Proteine), oxygen- and 2-oxoglutarate-dependent prolyl-4-hydroxylases that regulate HIF activity.
This study showed that polycythemia alone and increased levels of plasma Epo blunt the hypercapnic ventilatory response (HCVR); mice with an augmented level of cerebral Epo also had a decreased HCVR.
EPO might play a role as a survival factor or as a mitogen in developing cartilage tissue.
Pyruvate-fortified cardioplegia evokes myocardial erythropoietin signaling in swine undergoing cardiopulmonary bypass.
A single intramuscular injection of recombinant adeno (zeige ADORA2A Proteine)-associated virus carrying mutant Epo (R76E) preserves retinal ganglion cells and visual function in glaucomatous mice.
The zebrafish epo cDNA was cloned and the expression of zepo mRNA was mainly in the heart and liver.
characterization of zebrafish epo and epor (zeige EPOR Proteine) demonstrates the conservation of an ancient program that ensures proper red blood cell numbers during normal homeostasis and under hypoxic conditions
This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types.