anti-Egl Nine Homolog 2 (C. Elegans) (EGLN2) Antikörper

Bezeichnung:
anti-Egl Nine Homolog 2 (C. Elegans) Antikörper (EGLN2)
Auf www.antikoerper-online.de finden Sie aktuell 127 Egl Nine Homolog 2 (C. Elegans) (EGLN2) Antikörper von 15 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Egl Nine Homolog 2 (C. Elegans) Proteine (9) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 146 Egl Nine Homolog 2 (C. Elegans) Produkte verfügbar.
Synonyme:
0610011A13Rik, C85656, egln2, EIT6, Hif-p4h-1, HIF-PH1, HIFPH1, HPH-1, HPH-3, Ier4, PHD-1, Phd1, phd2, SM-20

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Am meisten referenzierte anti-Egl Nine Homolog 2 (C. Elegans) Antikörper

  1. Human Polyclonal EGLN2 Primary Antibody für EM, ICC - ABIN151776 : Li, Yi, Sundy, Chen, Hilliker, Donley, Muldoon, Li: Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys. in American journal of physiology. Renal physiology 2007 (PubMed)
    Zeige alle 39 Referenzen für 151776

  2. Human Polyclonal EGLN2 Primary Antibody für EIA, WB - ABIN952039 : Winning, Splettstoesser, Fandrey, Frede: Acute hypoxia induces HIF-independent monocyte adhesion to endothelial cells through increased intercellular adhesion molecule-1 expression: the role of hypoxic inhibition of prolyl hydroxylase activity for the induction of NF-kappa B. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)
    Zeige alle 2 Referenzen für 952039

  3. Dog (Canine) Polyclonal EGLN2 Primary Antibody für WB - ABIN2778438 : Pan, Mansfield, Bertozzi, Rudenko, Chan, Giaccia, Simon: Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro. in Molecular and cellular biology 2007 (PubMed)
    Zeige alle 2 Referenzen für 2778438

  4. Human Polyclonal EGLN2 Primary Antibody für EIA, WB - ABIN453633 : Semenza: HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. in Cell 2001 (PubMed)
    Zeige alle 2 Referenzen für 453633

  5. Human Polyclonal EGLN2 Primary Antibody für FACS, IHC (p) - ABIN652648 : Aprelikova, Pandolfi, Tackett, Ferreira, Salnikow, Ward, Risinger, Barrett, Niederhuber: Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response. in Cancer research 2009 (PubMed)

  6. Cow (Bovine) Polyclonal EGLN2 Primary Antibody für WB - ABIN2775821 : Appelhoff, Tian, Raval, Turley, Harris, Pugh, Ratcliffe, Gleadle: Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. in The Journal of biological chemistry 2004 (PubMed)

  7. Cow (Bovine) Polyclonal EGLN2 Primary Antibody für WB - ABIN2775992 : Gilbert, Banek, Bauer, Gingery, Needham: Exercise training attenuates placental ischemia-induced hypertension and angiogenic imbalance in the rat. in Hypertension 2012 (PubMed)

Weitere Antikörper gegen Egl Nine Homolog 2 (C. Elegans) Interaktionspartner

Xenopus laevis Egl Nine Homolog 2 (C. Elegans) (EGLN2) Interaktionspartner

  1. comparative analysis of phd1, 2, and 3 expression in Xenopus laevis

Mouse (Murine) Egl Nine Homolog 2 (C. Elegans) (EGLN2) Interaktionspartner

  1. Phd1 deficiency in dendritic cells significantly reduced interleukin-1beta production in response to lipopolysaccharide. Taken together, our results further support the development of selective PHD1 inhibitors for ulcerative colitis, and identify haematopoietic cells as their primary target.

  2. PHD1 deficiency promotes hepatic steatosis and liver-specific insulin (zeige INS Antikörper) resistance but does not worsen the deleterious effects of HFD on metabolic homeostasis.

  3. deleting Phd1-3 genes in osteoblasts increased osteoclast formation in vitro and in bone.

  4. These data identify PHD1 as a regulator of neuronal metabolism and a potential therapeutic target in ischemic stroke.

  5. PHD1 and PHD3 (zeige EGLN3 Antikörper) deletions promote angiogenesis in ischemia-injured tissue by increasing HIF1-alpha (zeige HIF1A Antikörper) stability.

  6. Rosiglitazone increases PHD (zeige PDC Antikörper) expression in a PPARgamma (zeige PPARG Antikörper)-dependent manner and that this leads to the commitment of anti-adipogenic proteins to the ubiquitination-proteasomal pathway and to the subsequent induction of adipocyte differentiation.

  7. PHD-1 deficient mouse appears to be the first animal model showing neuroepithelial bodies cell hyperplasia

  8. Alterations in the function of all 3 isoforms of prolyl-4-hydroxylase enzymes (PHD1-3) in the first 24 h following transient focal cerebral ischaemia are reported.

  9. Data show it is feasible to reactivate hepatic erythropoietin (zeige EPO Antikörper) production using systemically delivered siRNAs targeting the EglN1 (zeige EGLN1 Antikörper), EglN2 and EglN3 (zeige EGLN3 Antikörper) prolyl hydroxylase mRNA specifically in the liver.

  10. silencing of PHD-1 attenuates myocardial ischemia/reperfusion injury probably by enhancing HIF-1alpha (zeige HIF1A Antikörper)/beta-catenin (zeige CTNNB1 Antikörper)/endothelial nitric oxide synthase (zeige NOS3 Antikörper)/nuclear factor-kappaB and Bcl-2 (zeige BCL2 Antikörper) signaling pathway

Human Egl Nine Homolog 2 (C. Elegans) (EGLN2) Interaktionspartner

  1. PHD1 is phosphorylated by CDK2 (zeige CDK2 Antikörper), CDK4 (zeige CDK4 Antikörper) and CDK6 (zeige CDK6 Antikörper) at Serine 130.

  2. siRNA-mediated knockdown of PHD1 inhibited glucose-stimulated insulin (zeige INS Antikörper) secretion in pancreatic Beta cells.

  3. EglN2 associates with the NRF1 (zeige NFE2L1 Antikörper)-PGC1alpha complex and controls mitochondrial function in breast cancer

  4. rs3733829 in the EGLN2 gene is significantly associated with the risk of COPD (zeige ARCN1 Antikörper) in Chinese populations of Hainan province.

  5. Germ-line PHD1 and PHD2 (zeige EGLN1 Antikörper) mutations detected in patients with pheochromocytoma/paraganglioma-polycythemia

  6. study conducted to investigate the association between gastric cancer (GC) susceptibility with a 4-bp insertion/deletion polymorphism (rs10680577) in the proximal promoter of EGLN2; findings showed that the heterozygote and the homozygote 4-bp del/del confer a significantly increased risk of GC

  7. Data indicate that the prolyl hydrolase 1 (PHD1) rs10680577 polymorphism is associated with the risk of non-small cell lung cancer in a Chinese population.

  8. PHD-1 played an important role in hypoxic response pathway of trophoblast through modulating the level of HIF-2alpha (zeige EPAS1 Antikörper).

  9. PHD1 could induce cell cycle arrest in lung cancer cells, resulting in the suppression of cell proliferation.

  10. Results show that variants in two adjacent genes, EGLN2 and CYP2A6 (zeige CYP2A6 Antikörper), influence smoking behavior related to disease risk.

Egl Nine Homolog 2 (C. Elegans) (EGLN2) Antigen-Profil

Beschreibung des Gens

The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene.

Alternative names and synonyms associated with Egl Nine Homolog 2 (C. Elegans) (EGLN2)

  • egl nine homolog 1 (egln1) Antikörper
  • egl nine homolog 2 (C. elegans) (EGLN2) Antikörper
  • Egl nine homolog 2 (egln2) Antikörper
  • egl nine homolog 2 (egln2) Antikörper
  • EGL nine homolog 2 (C. elegans) (Egln2) Antikörper
  • egl-9 family hypoxia-inducible factor 2 (EGLN2) Antikörper
  • 0610011A13Rik Antikörper
  • C85656 Antikörper
  • egln2 Antikörper
  • EIT6 Antikörper
  • Hif-p4h-1 Antikörper
  • HIF-PH1 Antikörper
  • HIFPH1 Antikörper
  • HPH-1 Antikörper
  • HPH-3 Antikörper
  • Ier4 Antikörper
  • PHD-1 Antikörper
  • Phd1 Antikörper
  • phd2 Antikörper
  • SM-20 Antikörper

Bezeichner auf Proteinebene für EGLN2

EGL nine homolog 2 , egl nine homolog 2 , Egl nine homolog 2 , EGL nine (C.elegans) homolog 2 , egl nine homolog 2 (C. elegans) , egl nine homolog 2-like , HIF-PH1 , HIF-prolyl hydroxylase 1 , HPH-1 , falkor , hypoxia-inducible factor prolyl hydroxylase 1 , immediate early response 4 , prolyl hydroxylase domain-containing protein 1 , HIF-1alpha prolyl-4-hydroxylase-1 , estrogen-induced tag 6

GENE ID SPEZIES
548714 Xenopus (Silurana) tropicalis
100172704 Pongo abelii
100306807 Salmo salar
456049 Pan troglodytes
703083 Macaca mulatta
100523673 Sus scrofa
100584172 Nomascus leucogenys
100158265 Xenopus laevis
112406 Mus musculus
484495 Canis lupus familiaris
308457 Rattus norvegicus
536763 Bos taurus
112398 Homo sapiens
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