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Following spring viremia of carp (zeige ANKRD1 ELISA Kits) virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp (zeige ANKRD1 ELISA Kits) virus. data provide evidence that fish and mammals have evolved a similar IRF (zeige TRIM63 ELISA Kits)-dependent regulatory mechanism fine-tuning IFN gene activation.
A comprehensive mass spectrometric analysis identified interferon regulatory factor 1 (IRF1) as a key transcription factor in growth arrest of LNCaP-mTOR (zeige FRAP1 ELISA Kits).
IFN regulatory factor 1 effectively inhibits hepatitis E virus replication through the activation of the JAK (zeige JAK3 ELISA Kits)-STAT (zeige STAT1 ELISA Kits) pathway
B. abortus lipoproteins via IL-6 (zeige IL6 ELISA Kits) inhibit the expression of IFN regulatory factor 1 (IRF-1), a critical regulatory transcription factor for CIITA (zeige CIITA ELISA Kits) induction.
STAT1 (zeige STAT1 ELISA Kits) and IRF1 collaborate to induce interferon-gamma (zeige IFNG ELISA Kits) stimulated genes (ISGs), but the extent to which they act alone or together is unclear.This study provides strong evidence for widespread cooperation between STAT1 (zeige STAT1 ELISA Kits) and IRF1 at ISGs, and suggests that in silico predictions reliably predict the effect of nucleotide variants on binding in vivo.
aimed to determine the role of Treg cells and IRF-1 in MDS (zeige PAFAH1B1 ELISA Kits)
Tat (zeige TAT ELISA Kits) exploited the cellular HDM2 (human double minute 2 protein (zeige MDM2 ELISA Kits)) ubiquitin ligase to accelerate IRF-1 proteasome-mediated degradation, resulting in a quenching of IRF-1 transcriptional activity during HIV-1 infection.
Leading to a STAT1 (zeige STAT1 ELISA Kits)-IRF1 controlled upregulation of TLR3 (zeige TLR3 ELISA Kits) expression in macrophages.
Regulatory elements for both IRF-1 (-1019 to -1016) and CREB (zeige CREB1 ELISA Kits) (-1198 to -1195), specific to the distal THBS1 (zeige THBS1 ELISA Kits) promoter, were required for leptin (zeige LEP ELISA Kits)-induced TSP-1 (zeige THBS1 ELISA Kits) transcription.
silencing of IL1B (zeige IL1B ELISA Kits) plus dexamethasone-induced DUSP1 (zeige DUSP1 ELISA Kits) significantly reduced IRF1 expression. IL1B (zeige IL1B ELISA Kits)-induced expression of CXCL10 (zeige CXCL10 ELISA Kits) was largely insensitive to dexamethasone, whereas other DUSP1 (zeige DUSP1 ELISA Kits)-enhanced, IRF1-dependent mRNAs showed various degrees of repression.
Inflammation-driven IRF1 and NF-kappaB (zeige NFKB1 ELISA Kits) activity promotes ERVK reactivation.
Given these results, porcine IRF1 plays potential roles in cellular antiviral responses against swine viruses.
In a healthy swine model, elevated levels of endothelial IRF-1 were also observed within atherosusceptible regions of the aorta by Western blot analysis and immunohistochemistry, implicating arterial hemodynamics in the regulation of IRF-1 expression.
The results suggested that the porcine IRF1 gene is strong candidate gene for these immune traits in pig.
Our studies uncovered the critical role of two transcription factors, IRF1 and BATF, in preparing the chromatin landscape for induction of the Tr1 gene network in response to IL-27 signaling, where BATF acted as a pioneer factor and prepared the genomic landscape for the binding of additional transcription factors that define the Tr1 lineage.
IRF-1 and interferon-alpha (zeige IFNA ELISA Kits) with interferon-beta (zeige IFNB1 ELISA Kits) cooperate to control acute gammaherpesvirus infection.
this study shows that binding motifs for the transcription factors STAT1 (zeige STAT1 ELISA Kits) and IRF1 are associated with robust and IL-4 (zeige IL4 ELISA Kits)-resistant responses to IFN-gamma (zeige IFNG ELISA Kits) in macrophages
5AZ had a protective effect after MI by potentiation of IRF1 sumoylation and is suggested as a novel therapeutic intervention for cardiac repair.
direct the expression of a set of genes, the IRF8 (zeige IRF8 ELISA Kits)/IRF1 regulome, that play critical roles in host inflammatory and antimicrobial defenses in mouse models of neuroinflammation and of pulmonary tuberculosis, respectively
couples synthesis of miR (zeige MLXIP ELISA Kits)-342-5p to the antiviral interferon (zeige IFNA ELISA Kits) response
The gammaherpesvirus-driven germinal center expansion was exaggerated and lost its transient nature in the absence of interferon-regulatory factor 1 (IRF-1), a transcription factor with antiviral and tumor suppressor functions.
IRF1 is required for IRF8 (zeige IRF8 ELISA Kits)-induced gene expression in microglia.
in addition to regulating the enterocyte metabolic switch, Blimp1 functions as a gatekeeper in opposition to Irf1 to prevent premature activation of the MHC class I pathway in villus epithelium to maintain tolerance in the neonatal intestine.
Although treatment with IFN-gamma (zeige IFNG ELISA Kits) strongly induced the activation of STAT1 (zeige STAT1 ELISA Kits) as a transcriptional activator, its target molecule, IRF1, was not clearly produced in Lmp2 (zeige PSMB9 ELISA Kits)-deficient uterine smooth muscle cells.
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.
interferon regulatory factor 1
, interferon regulatory factor 11
, interferon responsive factor 1