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results suggest VGF enhances dendritic maturation and that these effects can be altered by common SNPs in the VGF gene
We conclude that some of the already identified variants in VGF from human polymorphism studies may contribute to eating disorders and obesity.
Data show although no any significant differences between patient groups and lean subjects of proteins SYT4 (zeige SYT4 Proteine), BAG3 (zeige BAG3 Proteine), APOA1 (zeige APOA1 Proteine), and VAV3 (zeige VAV3 Proteine), except for VGF protein, there was a trend between the expression of these four genes and their protein levels.
Data show that two VGF peptides (NAPP-19 and QQET-30) were identified in plasma.
Data indicate an increased number of neurosecretory protein VGF-expressing T cells in patients with Alzheimer's disease (AD) compared to aged healthy controls.
Results indicate that neuron-restrictive silencer factor plays an important role as a repressor of VGF gene regulation in neuroblastoma (zeige ARHGEF16 Proteine) cells through a mechanism that is dependent on VGF-neuron-restrictive silencer element
NERPs may be potent endogenous suppressors of glucose-dependent insulin (zeige INS Proteine) secretion.
DISC1 (zeige DISC1 Proteine) knockdown leads to a reduction of VGF in neurons.
Knock-in mice expressing human VGF were fertile, had increased body weight, whereas those with c-terminal region deletion had reduced adiposity, increased energy expenditure, and improved glucose tolerance.
We conclude that VGF contributes to survival and function of peripheral T cells
These observed changes in energy expenditure and food intake were associated with an increase in the hypothalamic contents of the VGF-derived peptides AQEE, TLQP and NERP-2. The complex phenotype of the VGF-/- mice is a likely consequence of global ablation of the gene and its derived peptides during development, as well as in the adult.
GnRH (zeige GNRH1 Proteine) stimulated the secretion of the VGF-derived peptide NERP1. NERP1 caused a concentration-dependent decrease in Fshb (zeige FSHB Proteine) gene induction.
results suggest hypothalamic VGF responds to environmental demands and plays an important role in energy balance and glycemic control likely acting in the melanocortin pathway downstream of BDNF (zeige BDNF Proteine).
Data indicate that high-fat diet induced obese mice showed reduced plasma VGF C-terminus, NAPPE and QQET-like (ERVW) peptide.
VGF expression is regulated by DISC1 (zeige DISC1 Proteine) through the activation of the PI3K/AKT (zeige AKT1 Proteine)/CREB (zeige CREB1 Proteine) pathway.
This study found that VGF expression, both mRNA and protein, was increased 1 h after training in the dorsal hippocampus.
Derived from the C-terminus of VGF, endogenous TLQP-21 peptide contributes to the mechanisms of spinal neuroplasticity after inflammation and nerve injury.
VGF has a role in adrenal large dense core vesicle formation and the regulation of catecholamine levels and blood pressure
These findings reveal that NERP-2 regulates glucose-stimulated insulin (zeige INS Proteine) secretion by elevating intracellular calcium concentrations.
VGF is regulated by SOD1 (zeige SOD1 Proteine) and plays a critical role in motor neuron survival
This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known.
VGF nerve growth factor inducible
, Neurosecretory protein VGF
, neuro-endocrine specific protein VGF
, neurosecretory protein VGF
, VGF8a protein