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Human SHBG Protein expressed in Human - ABIN935784
Hauptmann, Metzger, Schnitzbauer, Cuilleron, Mappus, Luppa: Syntheses and ligand-binding studies of 1 alpha- and 17 alpha-aminoalkyl dihydrotestosterone derivatives to human sex hormone-binding globulin. in Steroids 2003
characterization of the zebrafish SHBG gene and protein through molecular biological, biochemical, and informatics approaches
SHBG controls the flux of sex steroids across fish.
A wave of apoptosis during the pre-pubertal period is required for normal spermatogenesis to develop, and our data indicate that this apoptotic wave may be regulated by ABP and/or androgens.
USF transcription factors repress SHBG transcription in Sertoli cells through an interaction with FP4 within its proximal promoter
monosaccharide-induced lipogenesis reduced hepatic HNF-4alpha (zeige HNF4A Proteine) levels, which in turn attenuated SHBG expression.
In vitro androgen bioactivity reflects the inhibitory effects of SHBG.
In men with hepatic steatosis, we found that elevated serum ALT levels were associated with lower serum SHBG levels.
In the total population adjusting for race/ethnicity, there was no association between SHBG and fracture in women. The interaction between race/ethnicity and SHBG was also not statistically significant.
Depression and anxiety in subfertile males are associated with lower secretion of SHBG.
UBQLN4 (zeige UBQLN4 Proteine), APP (zeige APP Proteine), CTNNB1 (zeige CTNNB1 Proteine), SHBG, and COL1A1 (zeige COL1A1 Proteine) might be involved in the development of nonalcoholic fatty liver disease, and are proposed as the potential markers for predicting the development of this condition
Male infertility is associated with GA genotype and A allele of rs6259 locus, as well as CC genotype of rs727428 locus in SHBG gene
Low serum SHBG was the most relevant factor for prediabetes and diabetes
two non-linked SNPs (rs6259 and rs9901675) at the SHBG gene locus might be of importance for language impairment problems in boys.
Data suggest there is a strong inverse correlation between SHBG (sex hormone-binding globulin) and DHEA (dehydroepiandrosterone) levels in cord blood obtained at birth from infants of both sexes; there are no associations between SHBG and testosterone or DHT (dihydrotestosterone) levels. This study was conducted in Sweden.
modulates hepatic lipogenesis; reduction of SHBG plasma levels in obese and type 2 diabetic subjects could be directly associated with nonalcoholic fatty liver disease development through an increase in hepatic lipogenesis
Three novel mutations with very damaging effect on the protein structure, according to SIFT and Polyphen-2, were detected in GART, SHBG and SLC37A2 genes.
This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein binds each steroid molecule as a dimer formed from identical or nearly identical monomers. The use of alternate promoters and alternatively spliced transcripts have been described. Multiple transcript variants encoding different isoforms have been found for this gene.
sex steroid-binding protein
, testis-specific androgen-binding protein
, testosterone-binding beta-globulin
, testosterone-estradiol-binding globulin
, testosterone-estrogen-binding globulin
, sex hormone-binding globulin
, Sex hormone binding globulin or androgen-binding protein (other gene product from ABP gene)
, androgen binding protein 1 (296 AA)
, sex hormone binding globulin
, sex hormone-binding globulin protein
, LOW QUALITY PROTEIN: sex hormone-binding globulin
, sex hormone binding globulin L homeolog