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anti-Human GLI1 Antikörper:
anti-Rat (Rattus) GLI1 Antikörper:
anti-Mouse (Murine) GLI1 Antikörper:
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Human Polyclonal GLI1 Primary Antibody für ChIP, ELISA - ABIN153487
Ghali, Wong, Green, Tidman, Quinn: Gli1 protein is expressed in basal cell carcinomas, outer root sheath keratinocytes and a subpopulation of mesenchymal cells in normal human skin. in The Journal of investigative dermatology 1999
Show all 28 Pubmed References
Cow (Bovine) Polyclonal GLI1 Primary Antibody für WB - ABIN2779593
Rahnama, Shimokawa, Lauth, Finta, Kogerman, Teglund, Toftgård, Zaphiropoulos: Inhibition of GLI1 gene activation by Patched1. in The Biochemical journal 2006
Show all 9 Pubmed References
Human Polyclonal GLI1 Primary Antibody für IF (p), IHC (p) - ABIN673374
Zhang, Zhu, Zhou, Gao, Yuan, Han: Serotonin receptor 2C and insulin secretion. in PLoS ONE 2013
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Human Polyclonal GLI1 Primary Antibody für ICC, IF - ABIN4314249
Jalili, Mertz, Romanov, Wagner, Kalthoff, Stuetz, Pathria, Gschaider, Stingl, Wagner: NVP-LDE225, a potent and selective SMOOTHENED antagonist reduces melanoma growth in vitro and in vivo. in PLoS ONE 2013
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High gli1 expression is associated with Small Cell Lung Cancer.
This inhibitory effect on cell growth was partially rescued by exogenous KRT17 (zeige KRT17 Antikörper) expression. In the KRT17 (zeige KRT17 Antikörper)-positive regions in OSCCs, GLI-1 or GLI-2 (zeige GLI2 Antikörper) was frequently detected, and the number of cells with cleaved caspase-3 (zeige CASP3 Antikörper) positive was decreased. CONCLUSIONS: KRT17 (zeige KRT17 Antikörper) promotes tumor cell growth, at least partially, through its anti-apoptotic effect as a result of the KRT17 (zeige KRT17 Antikörper) overexpression by GLIs in OSCC
Results indicate that GLI1 is important for maintaining the invasive and mesenchymal-like properties of melanoma cells independent of MITF (zeige MITF Antikörper).
The data described herein provide the first identification of a DYRK1A (zeige DYRK1A Antikörper)-mediated site of phosphorylation on GLI1 within its NLS (zeige ALDH1A2 Antikörper) and may serve as a valuable mechanism for further understanding Hh signaling modulation.
Case Report: gastric pericytoma harboring the exceptionally rare translocation t(7;12) resulting in ACTB (zeige ACTB Antikörper)-GLI1 gene fusion.
USP21 (zeige USP21 Antikörper) recruits and stabilises Gli1 at the centrosome.
Gli1 expression was significantly correlated with T stage lymph node metastasis, and clinical stage of lung squamous cell carcinoma.
Gli1 role in cell proliferation and differentiation
Gli1 inhibitor GANT61 and SHH (zeige SHH Antikörper) siRNA synergistically enhanced cytotoxicity induced by itraconazole in MCF-7 cells.
Hedgehog (zeige SHH Antikörper) pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors.
Data indicate that the expression levels of transcription factors Gli1 and Gli2 (zeige GLI2 Antikörper) in muscle were the lowest of the 13 tissues.
Dzip1 (zeige DZIP1 Antikörper)-dependent stabilization of Spop (zeige SPOP Antikörper)/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway.
Zyxin (zeige ZYX Antikörper) inhibits Shh (zeige SHH Antikörper) signaling during the CNS patterning in Xenopus laevis through interaction with Gli1
Mutation of hmgcs1 (zeige HMGCS1 Antikörper) had no effect on Shh (zeige SHH Antikörper) signaling at 2 and 3 days post fertilization (dpf), but did result in a decrease in the expression of gli1, a known Shh (zeige SHH Antikörper) target gene, at 4 dpf, after morphological deficits in craniofacial development and chondrocyte differentiation were observed in hmgcs1 (zeige HMGCS1 Antikörper) mutants.
a new mechanism of Gli transcription factor activation and implicate ARHGAP36 (zeige ARHGAP36 Antikörper) dysregulation in the onset and/or progression of GLI-dependent cancers.
We show that Kif7 (zeige KIF7 Antikörper) interacts with both Gli1 and Gli2a and suggest that it functions to sequester Gli proteins in the cytoplasm, in a manner analogous to the regulation of Ci by Cos2 (zeige KIF7 Antikörper) in Drosophila.
Gli1 has a Hh-independent role in many motoneurons and V3 domain cells in embryos that lack Hh signalling, but removal of Gli1 activity does not affect more dorsal neurons.
These results reveal divergent requirements for Gli1 and Gli2 (zeige GLI2 Antikörper) in mouse and zebrafish and indicate that zebrafish Gli1 is an activator of Hh-regulated genes, while zebrafish Gli2 (zeige GLI2 Antikörper) has minor roles as a repressor or activator of Hh targets.
Gli1 regulates the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl (zeige SGPL1 Antikörper)) factor activity.
Shh (zeige SHH Antikörper) production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma
Gli1-expressing bone marrow cells are responsible for primary myelofibrosis in a transgenic mouse model.
High Gli1 expression is associated with leukemia.
Sufu (zeige SUFUH Antikörper) is upregulated in active Shh (zeige SHH Antikörper) responding tissues and accompanies Gli activators translocating into and Gli repressors out of the nucleus.
Gli1 and Gli2 exhibited different functions in the regulation of p63 expression or proliferation of p63(+) cells in Kras-AR driven tumors.
NANOG (zeige NANOG Antikörper) binds to GLI1 and GLI3 (zeige GLI3 Antikörper) proteins and represses Hedgehog (zeige SHH Antikörper)-mediated transcription.
characterization of the contribution to remyelination of a subset of adult neural stem cells, identified by their expression of Gli1, a transcriptional effector of the sonic hedgehog (zeige SHH Antikörper) pathway
the three GLI factors(GLI1, GLI2 (zeige GLI2 Antikörper), and GLI3 (zeige GLI3 Antikörper)) in mature hepatocytes form an interactive transcriptional network that is involved in the control of target genes associated with metabolic zonation as well as with lipid and drug metabolism
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.
glioma-associated oncogene 1
, glioma-associated oncogene homolog 1 (zinc finger protein)
, oncogene GLI
, zinc finger protein GLI1
, GLI-Kruppel family member GLI1
, GLI family zinc finger 1, gene 1
, zinc finger DNA binding protein Gli-1
, glioma-associated oncogene homolog
, zinc finger protein 5