anti-HtrA Serine Peptidase 1 (HTRA1) Antikörper

anti-HtrA Serine Peptidase 1 Antikörper (HTRA1)
Auf finden Sie aktuell 73 HtrA Serine Peptidase 1 (HTRA1) Antikörper von 14 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen HtrA Serine Peptidase 1 Kits (29) und HtrA Serine Peptidase 1 Proteine (20) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 127 HtrA Serine Peptidase 1 Produkte verfügbar.
AI429470, ARMD7, CARASIL, HTRA, HTRA1, L56, MGC145723, ORF480, Prss11, RSPP11, Xhtra1, zgc:92029, zgc:172061

Meistgesuchte Reaktivitäten zu anti-HtrA Serine Peptidase 1 (HTRA1) Antikörper

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Am meisten referenzierte anti-HtrA Serine Peptidase 1 Antikörper

  1. Human Polyclonal HTRA1 Primary Antibody für IHC (p), WB - ABIN388128 : Chamberland, Wang, Jones, Collins-Racie, LaVallie, Huang, Liu, Morris, Flannery, Yang: Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo. in The Journal of biological chemistry 2009 (PubMed)
    Zeige alle 5 Referenzen für 388128

  2. Human Polyclonal HTRA1 Primary Antibody für IF, IHC (p) - ABIN388127 : Hu, Carozza, Klein, Nantermet, Luk, Crowl: Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage. in The Journal of biological chemistry 1999 (PubMed)
    Zeige alle 5 Referenzen für 388127

  3. Human Polyclonal HTRA1 Primary Antibody für EIA, IHC (p) - ABIN356844 : Howes, Lerch, Greenhalf, Stocken, Ellis, Simon, Truninger, Ammann, Cavallini, Charnley, Uomo, Delhaye, Spicak, Drumm, Jansen, Mountford, Whitcomb, Neoptolemos: Clinical and genetic characteristics of hereditary pancreatitis in Europe. in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2004 (PubMed)
    Zeige alle 3 Referenzen für 356844

  4. Cow (Bovine) Polyclonal HTRA1 Primary Antibody für ICC, IF - ABIN4320643 : Clawson, Bui, Xin, Wang, Pan: Intracellular localization of the tumor suppressor HtrA1/Prss11 and its association with HPV16 E6 and E7 proteins. in Journal of cellular biochemistry 2008 (PubMed)
    Zeige alle 2 Referenzen für 4320643

  5. Human Polyclonal HTRA1 Primary Antibody für ICC, IF - ABIN4320641 : Wang, Eckert, Zomorrodi, Xin, Pan, Shearer, Weisz, Maranus, Clawson: Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways. in PLoS ONE 2012 (PubMed)

Weitere Antikörper gegen HtrA Serine Peptidase 1 Interaktionspartner

Zebrafish HtrA Serine Peptidase 1 (HTRA1) Interaktionspartner

  1. HtrA1 is indispensable for dorsoventral patterning in early zebrafish embryogenesis and serves as a key upstream regulator of FGF signaling through the control of FGF levels.

Rhesus Monkey HtrA Serine Peptidase 1 (HTRA1) Interaktionspartner

  1. Our data point to a yet unexpected effect of decreased HTRA1 expression on drusen pathogenesis. Thus not only a higher HTRA1 expression, but an imbalance of HTRA1 might be disease-relevant.

  2. Tests for association revealed a variant in the promoter region of HTRA1 and two variants in the 5'-UTR (zeige UTS2R Antikörper) of ARMS2 (zeige ARMS2 Antikörper) to be associated with drusen.

  3. As in humans, one variant within LOC387715/ARMS2 (zeige ARMS2 Antikörper) and one in HTRA1 were significantly associated with age-related macular degeneration.

Human HtrA Serine Peptidase 1 (HTRA1) Interaktionspartner

  1. Results show that HTRA1 is epigenetically silenced in HCT116 colon carcinoma cells and during early stages of tumorigenesis in a mouse model of intestinal cancer. Downregulation of HTRA1 causes a multiple phenotypes that are hallmarks of cancer cells including increased proliferation of mouse embryonic fibroblasts, as well as chromosome and centrosome amplifications.

  2. High HTRA1 expression is associated with cervical cell proliferation.

  3. Data indicate HtrA serine peptidase 1 (HTRA1) involvement in Age-related macular degeneration (AMD (zeige AMD1 Antikörper)) pathogenesis.

  4. Variants in HTRA1 are not associated with age-related macular degeneration.

  5. Results show the heterozygous missense mutations p.G283E, p.P285L, p.R302Q, and p.T319I in the HTRA1 gene in 8 patients with symptomatic cerebral small vessel disease; mutant HTRA1s observed in manifesting heterozygotes might result in an impaired HTRA1 activation cascade of HTRA1 or be unable to form stable trimers

  6. FN and HtrA1 are localized in the placental key growth zones suggesting a pivotal role in maintaining the balance among the molecules involved in the placental development and differentiation

  7. correlation between TGFb1 (zeige TGFB1 Antikörper) and pSmad2 as well as between HtrA1 and TGFb1 (zeige TGFB1 Antikörper) and the very significant increase of Ki67 (zeige MKI67 Antikörper) in stromal compartment of eutopic endometrium suggest a possible involvement of HtrA1 in the pathogenesis of endometriosis.

  8. Two synonymous polymorphisms in exon 1 of the HTRA1 gene result in a protein with altered thermophoretic properties.

  9. significant increase of serum HtrA1 in early-onset pre-eclampsia

  10. a frameshift mutation in the HTRA1 gene detected in a CARASIL pedigree resulted in reduced HTRA1 protein and increased TGF-beta1 (zeige TGFB1 Antikörper) expression, which may cause severe CARASIL and peripheral small arterial disease

Mouse (Murine) HtrA Serine Peptidase 1 (HTRA1) Interaktionspartner

  1. transfection of cells with a constitutively active rapamycin-resistant p70S6K (zeige RPS6KB1 Antikörper) mutant could restore the mineralizing capacity of HtrA1-deficient mouse adipose-derived stromal cells.

  2. Increased expressions of Tgf-beta1 (zeige TGFB1 Antikörper), p-Smad2 (zeige SMAD2 Antikörper)/3 and HtrA1 were detected in the articular chondrocytes of knee joints in models of osteoarthritis.

  3. In mouse brain tissue and embryonic fibroblasts there is a facilitating role of HtrA1 in TGF-beta (zeige TGFB1 Antikörper) pathway activation.

  4. HtrA1 plays important roles in the differentiation of trophoblasts from Tpbpa-positive precursors in the ectoplacental cone

  5. The HtrA1 overexpression and mainstream cigarette smoke can independently lead to CNV. The HtrA1 gene is a strong risk factor for wet AMD (zeige AMD1 Antikörper)

  6. the inhibitory effect of IFN-gamma (zeige IFNG Antikörper) on HTRA1 expression was evidenced in collagen-induced arthritis (CIA (zeige NCOA5 Antikörper)) mouse models and in human RA synovial cells.

  7. Serine protease HTRA1 antagonizes transforming growth factor-beta signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation.

  8. Data show that HtrA1 is produced during osteoclastogenesis, and negatively regulates osteoblast differentiation, osteoblast differentiation and BMP2 (zeige BMP2 Antikörper)-induced Smad1 (zeige SMAD1 Antikörper)/5/8, ERK1/2 (zeige MAPK1/3 Antikörper) and p38 (zeige CRK Antikörper) phosphorylation in pre-osteoblasts.

  9. This study offers new insights into the regulation of HTRA-1 expression via LPS (zeige TLR4 Antikörper)/TLR-4 (zeige TLR4 Antikörper) and the role of HTRA-1 in rheumatoid arthrisis pathogenesis.

  10. suggest a critical role for LRP1 (zeige LRP1 Antikörper) in maintaining the integrity of vessels by regulating protease activity as well as matrix deposition by modulating HtrA1 and connective tissue growth factor (zeige CTGF Antikörper) protein levels.

Xenopus laevis HtrA Serine Peptidase 1 (HTRA1) Interaktionspartner

  1. The results are consistent with a mechanism by which xHtrA1, through cleaving proteoglycans, releases cell-surface-bound Fibroblast Growth Factors (FGF) ligands and stimulates long-range FGF signaling.

HtrA Serine Peptidase 1 (HTRA1) Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7.

Alternative names and synonyms associated with HtrA Serine Peptidase 1 (HTRA1)

  • HtrA serine peptidase 1a (htra1a) Antikörper
  • HtrA serine peptidase 1 (HTRA1) Antikörper
  • HtrA serine peptidase 1b (htra1b) Antikörper
  • HtrA serine peptidase 1 (htra1) Antikörper
  • Serine protease HTRA1 (htra1) Antikörper
  • HtrA serine peptidase 1 (Htra1) Antikörper
  • serine protease (HTRA) Antikörper
  • AI429470 Antikörper
  • ARMD7 Antikörper
  • CARASIL Antikörper
  • HTRA Antikörper
  • HTRA1 Antikörper
  • L56 Antikörper
  • MGC145723 Antikörper
  • ORF480 Antikörper
  • Prss11 Antikörper
  • RSPP11 Antikörper
  • Xhtra1 Antikörper
  • zgc:92029 Antikörper
  • zgc:172061 Antikörper

Bezeichner auf Proteinebene für HTRA1

HtrA serine peptidase 1 , high-temperature requirement A serine peptidase 1A , serine protease 11 , serine protease HTRA1A , high-temperature requirement A serine peptidase 1B , serine protease HTRA1B , high temperature required A1 , Serine protease HTRA1 , IGFBP5-protease , high-temperature requirement A serine peptidase 1 , protease, serine, 11 (IGF binding) , serine protease HTRA1 , insulin-like growth factor binding protein 5 protease , protease, serine, 11 (Igf binding) , IGF binding , protease, serine, 11 , protease serine 11 , High-temperature requirement A serine peptidase 1 , Serine protease 11

431766 Danio rerio
450792 Pan troglodytes
565082 Danio rerio
705855 Macaca mulatta
780187 Xenopus (Silurana) tropicalis
100064570 Equus caballus
100196695 Salmo salar
100541363 Meleagris gallopavo
100564246 Anolis carolinensis
100583976 Nomascus leucogenys
5654 Homo sapiens
56213 Mus musculus
477852 Canis lupus familiaris
282326 Bos taurus
65164 Rattus norvegicus
496061 Xenopus laevis
100857572 Gallus gallus
100008705 Oryctolagus cuniculus
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