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Human SDC1 Protein expressed in Human Cells - ABIN2004277
Zou, Chen, Zong, Ye, Tang, Meng, An, Zhang, Yang: Immunotherapy based on bispecific T-cell engager with hIgG1 Fc sequence as a new therapeutic strategy in multiple myeloma. in Cancer science 2015
all detectable Sdc found at the NMJ is provided by the muscle, strongly suggesting a post-synaptic role for Sdc. both the cytoplasmic and extracellular domains of Sdc are required to promote synapse growth or to rescue Sdc loss of function.
We conclude that Sdc cell autonomously regulates Slit/Robo2 signalling in tracheal cells to guarantee ordered directional migration and branch fusion.
In this study, we provide evidence that Dlp (zeige DMD Proteine) and Sdc have both overlapping and distinct functions in axon guidance and in defining accurate patterns of axonal fasciculation within the lateral CNS neuropil
Syndecan acting as a co-receptor for Slit in the Drosophila heart.
Syndecan (Sdc) is critical for the fidelity of Slit repellent signaling at the midline of the Drosophila CNS.
The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR (zeige PTPRF Proteine) receptor tyrosine phosphatase (zeige PTPRU Proteine).
Dlp (zeige DMD Proteine), which lacks chondroitin sulfate (CS)modifications, participates in the transfer of Slit from its site of expression to the target cells, where CS-modified Sdc concentrates and presents the ligand.
The above suggest that radiation-mediated premature senescence and invasive tumor cells, alone or in combination, enhance SDC1 expression in breast stromal fibroblasts, a poor prognostic factor for cancer growth, and that TGF-beta (zeige TGFB1 Proteine) plays a crucial role in this process.
A syndecan-1 level >/=40 ng/mL identified trauma patients with significantly worse outcomes, despite admission physiology similar to those without the condition.
overexpression of syndecan-1 confers to B-LCs an increased capacity to migrate in response to Tat, owing to a switch from a CXCR4/G-protein/Rac to a syndecan-1/alphavbeta3/pp60src/pp125FAK signal transduction pathway that depends on the formation of a complex in which syndecan-1 interacts with Tat via its HS-chains, with alphavbeta3 via its core protein ectodomain and with pp60src via its intracellular tail
MiR (zeige MLXIP Proteine)-331-3p-mediated miRNA maturation and enhanced epithelial-to-mesenchymal transition via effects on TGF-beta (zeige TGFB1 Proteine)/Smad 4 (zeige SMAD4 Proteine) and Dicer (zeige DICER1 Proteine) are essential for the development of prostate cancer mediated by syndecan-1.
The heparanase (zeige HPSE Proteine)/syndecan1 axis in gallbladder carcinoma cells plays an important role in the invasion and metastasis, thus providing a new therapeutic target.
Syndecan-1 acts as a novel tissue biomarker and a modulator of CSC phenotype of triple negative IBC via the IL-6 (zeige IL6 Proteine)/STAT3 (zeige STAT3 Proteine), Notch (zeige NOTCH1 Proteine) and EGFR (zeige EGFR Proteine) signaling pathways, thus emerging as a promising therapeutic target for IBC.
Hepatitis C virus infection downregulates Synd-1 and upregulates Xylt 2 (zeige XYLT2 Proteine) expression, likely contributing to a major glycocalyx reshuffle within days of infection.
Soluble Sdc1 is significantly lower before the clinical onset of preeclampsia, with reduced expression of Sdc1 in the delivered placenta, suggesting a role for glycocalyx disturbance in preeclampsia pathophysiology.
Heparanase (zeige HPSE Proteine) has emerged as a major regulator of cancer by degrading heparan sulfate thereby influencing multiple signaling pathways that control gene expression, syndecan shedding and cell behavior. (Review)
Study provides robust evidence in favor of the additional baseline soluble CD138 prognostic value for OS, in mCRC patients. A simple biological scoring system is proposed including LDH and CD138 binary status values.
Syntaxin-4 (zeige STX4 Proteine) not only bound to laminin but also latched onto the glycosaminoglycan side chains of syndecan-1, a laminin receptor that mediates epithelial morphogenesis. Thus, temporal extracellular extrusion of syntaxin-4 (zeige STX4 Proteine) emerged as a novel regulatory element for laminin-induced mammary epithelial cell behaviors.
2-O-sulfated (zeige SULF1 Proteine) domains in syndecan-1 heparan sulfate halt disease progression and promote liver repair by enhancing hepatocyte survival in acetaminophen-induced liver injury
CD138 expression on fully mature Antibody secreting cells (ASCs) provides a selective survival advantage over less mature, newly minted ASCs, by enhancing pro-survival cytokine signaling.
Sdc1 deficiency results in increased susceptibility to colitis-associated tumorigenesis.
MMP7 (zeige MMP7 Proteine) shedding of syndecan-1/CXCL1 (zeige CXCL1 Proteine) complexes functions as a checkpoint that restricts neutrophil activation at sites of epithelial injury.
Data show that heparanase-1 (HPA-1 (zeige HPSE Proteine)) induced shedding of heparan sulfate chain from syndecan-1 (SDC-1) facilitated the release of vascular endothelial growth factor C (VEGF-C (zeige VEGFC Proteine)) from SDC-1/VEGF-C (zeige VEGFC Proteine) complex into the medium of hepatocarcinoma cell.
This study indicates that, while syndecan-1 is important for providing a barrier to acute S. aureus infection in PD, it does not affect peritoneal fibrosis and angiogenesis.
Data suggest a potential mechanism of diabetic enteropathy, which is depending remarkably on syndecan-1 (Sdc1) and -beta-D-glucuronidase (zeige GUSB Proteine) heparanase (HPSE (zeige HPSE Proteine)).
Study showed the expression, distribution and function of syndecan-1 in primary sensory neurons after nerve injury
A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 (zeige ADAM17 Proteine) and promotes lung epithelial tumor cell migration and lung metastasis formation.
Heparan sulfate is involved in both centralized and decentralized glycocalyx-mediated mechanotransduction, with GPC1 (zeige GPC1 Proteine) acting as a centralized agent and SDC1 functioning in decentralized mechanotransmission. GPC1 (zeige GPC1 Proteine) mediates NOS3 (zeige NOS3 Proteine) activation.
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.
, syndecan 1
, CD138 antigen
, heparan sulfate proteoglycan fibroblast growth factor receptor
, syndecan proteoglycan 1