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HAS2 (zeige HAS2 Proteine) and HAS3 (zeige HAS3 Proteine) were the only hyaluronan synthases detected, the expression of which was almost similar in NPs (zeige NPS Proteine) and NM.
The receiver-operating characteristic curve analyses demonstrated that each one had good sensitivity and specificity for distinguishing BC patients from non-BC ones (HYAL1, miR (zeige MLXIP Proteine)-210, miR (zeige MLXIP Proteine)-96, lncRNA-UCA1, 91.5 and ).
Study showed that reduced HYAL1 expression was associated with endometrial carcinoma aggressiveness, which further supported the role of hyaluronan degradation in cancer progression.
Results demonstrated that HYAL1 was C-mannosylated and suggest the possible role of C-mannosylation for secretion and enzymatic activity of HYAL1.
Hyaluronan (HA) interacting proteins RHAMM (zeige HMMR Proteine) and hyaluronidase (zeige HAase Proteine) impact prostate cancer cell behavior and invadopodia formation in 3D HA-based hydrogels.
In contrast to the previously described MPS IX patient, our three patients display a phenotype limited to the joints, suggesting that this is the primary manifestation of HYAL1 deficiency.
Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis.
This is the first report showing high HYAL-1 levels in epithelial ovarian cancer.
HYAL-1 and HAS1 (zeige HAS1 Proteine) expression predicted BCa (zeige BLNK Proteine) metastasis, and HYAL-1 expression also predicted disease-specific survival.
HYAL1 overexpression is correlated with the malignant behavior of breast cancer.
results are consistent with a role for hyaluronan and hyaluronoglucosaminidase 1 and 2 in the development of the microscopic folds of the pig placenta during gestation
the porcine hyaluronidase (zeige HAase Proteine) cluster consisting of genes HYAL1, HYAL2 (zeige HYAL2 Proteine) and HYAL3 (zeige HYAL3 Proteine) was characterized
This study focuses on the investigation of the digestibility of glycosaminoglycans with different degrees of sulfation by bovine testicular hyaluronidase (zeige HAase Proteine).
It was concluded that: HYAL1 and HYAL2 (zeige HYAL2 Proteine) are both needed for tissue HA catabolism; 2) HYAL2 (zeige HYAL2 Proteine) is required for high MW HA clearance in lymph nodes and plasma and for HA endocytosis by liver NPCs; and 3) the main role of HYAL1 is HA degradation within liver NPCs.
Findings suggest that HYAL1 contributes to endothelial and glycocalyx dysfunction induced by diabetes. HYAL1 inhibitors could be explored as a new therapeutic approach to prevent vascular complications in diabetes.
HYAL1 is necessary for the breakdown of intracellular HA in the cortex, whereas HYAL2 (zeige HYAL2 Proteine) is essential for the degradation of extracellular HA in all kidney regions
The activity of the processed form of Hyal-1 was largely underestimated.
The knockdown of Hyal-1 results in an 80% decrease of total acid hyaluronidase (zeige HAase Proteine) activity in the mouse liver, confirming that Hyal-1 is a key actor of hyaluronic acid catabolism in this organ.
Chondroitin sulfate is a crucial determinant for skeletal muscle development/regeneration and improvement of muscular dystrophies through HYAL1
both HYAL1 and beta-hexosaminidase (zeige HEXA Proteine) cleave chondroitin sulfate, but it is a preferred substrate for beta-hexosaminidase (zeige HEXA Proteine). These studies provide in vivo evidence to support and extend existing knowledge of GAG breakdown.
Data show that Hyal-1, but not Hyal-3 (zeige HYAL3 Proteine),is an ovarian regulator factor for follicle development, and show an interrelationship between this enzyme and the follistatin (zeige FST Proteine)/activin/Smad3 (zeige SMAD3 Proteine) pathway.
Endothelial surface layer degradation by chronic hyaluronidase (zeige HAase Proteine) infusion induces proteinuria in apolipoprotein E (zeige APOE Proteine)-deficient mice
Characterization of the murine hyaluronidase (zeige HAase Proteine) gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 (zeige NAT6 Proteine) and Hyal3 (zeige HYAL3 Proteine).
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
, lung carcinoma protein 1
, plasma hyaluronidase
, tumor suppressor LUCA-1
, hyaluronidase 1