HSPG2 Proteine (HSPG2)

Bezeichnung:
Heparan Sulfate Proteoglycan 2 Proteine (HSPG2)
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Synonyme:
AI852380, HSPG, HSPG2, Pcn, per, Plc, PRCAN, SJA, SJS, SJS1
alle Proteine anzeigen Gen GeneID UniProt
HSPG2 3339 P98160
Ratte HSPG2 HSPG2 117511  
HSPG2 15530 Q05793

Weitere Synonyme anzeigen

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Weitere Proteine zu HSPG2 Interaktionspartnern

Rabbit Heparan Sulfate Proteoglycan 2 (HSPG2) Interaktionspartner

  1. Nidogen-1 (zeige NID1 Proteine) and nidogen-2 (zeige NID2 Proteine) mRNAs were highly expressed in keratocytes, whereas perlecan was highly expressed in myofibroblasts.

  2. RUS3108 is a novel perlecan-inducing compound which may prevent in-stent restenosis.

Human Heparan Sulfate Proteoglycan 2 (HSPG2) Interaktionspartner

  1. Putative stem cell populations associated with hair bulbs, humeral perichondrium, humeral and ulnar rudiment stromal/perivascular tissues expressed the Chondroitin sulfate motifs 4C3, 7D4, and 3B3[-] along with perlecan in close association but not colocalized.

  2. Heterozygous variants in HSPG2 regulate the ATP2B4 (zeige ATP2B4 Proteine) expression via a variety of transcription factors including GATA1 (zeige GATA1 Proteine), RFX1 (zeige RFX1 Proteine) and MAZ (zeige MAZ Proteine).

  3. the HSPG2-rs3767140 might be associated with the decreased fasting plasma glucose and LDL-C and with the increased HDL (zeige HSD11B1 Proteine)-C in diabetics.

  4. Together, perlecan fragments in sera and MMP-7 (zeige MMP7 Proteine) in tissues of Prostate cancer patients are measures of invasive Prostate cancer.

  5. Results show that perlecan has physical properties that would allow it to act as a strong but elastic tether in the lacunar canalicular system of cortical bone.

  6. We were able to identify perlecan as the most likely candidate for the major estrogen-binding protein in the follicular fluid.

  7. Knockdown of agrin (zeige AGRN Proteine) and perlecan promoted a decrease on cell migration and adhesion, and on resistance of cells to cisplatin.

  8. As five of the seven missense mutations in Schwartz-Jampel syndrome affect domain III of perlecan, domain III is likely to be essential for secretion of perlecan into the extracellular space.

  9. Rare variants in the HSPG2 gene potentially contribute to the idiopathic scoliosis phenotype in a subset of patients with idiopathic scoliosis

  10. The perlecan is the primary ECM (zeige MMRN1 Proteine) molecule comprising intraepithelial stroma of the junctional epithelium, in which leukocytes may migrate on ECM (zeige MMRN1 Proteine) scaffolds in intercellular space toward the surface of the gingival sulci or pockets.

Cow (Bovine) Heparan Sulfate Proteoglycan 2 (HSPG2) Interaktionspartner

  1. Blocking of perlecan by anti-perlecan antiserum inhibited the migration of vascular endothelial cells (VECs) and bone marrow-derived mesenchymal stem cells, and exogenous perlecan added to the culture medium promoted the migration of these cell types.

  2. RUS3108 is a novel perlecan-inducing compound which may prevent in-stent restenosis.

  3. Hyperglycemia-induced structural changes in perlecan may result in a subendothelial matrix that is more favorable to retention of monocytes. 2 forms of perlecan exist in BAEC SEM, 1 with HS chains only and 1 with both HS and CS/DS chains.

  4. results suggest that perlecan made by growth plate chondrocytes is a low affinity receptor for FGF-2 (zeige FGF2 Proteine) and acts to sequester FGF-2 (zeige FGF2 Proteine) away from the high affinity receptor

  5. data show that growth plate perlecan binds to FGF-2 (zeige FGF2 Proteine) by its heparan sulfate chains but can only deliver FGF-2 (zeige FGF2 Proteine) to FGF receptors when its chondroitin sulfate chains are removed.

Pig (Porcine) Heparan Sulfate Proteoglycan 2 (HSPG2) Interaktionspartner

  1. Perlecan is a defining factor in both the biochemical and biomechanical properties of the pericellular matrix.

Mouse (Murine) Heparan Sulfate Proteoglycan 2 (HSPG2) Interaktionspartner

  1. Confocal laser scanning microscopy co-localised perlecan with type VI collagen as pericellular components of intervertebral disc (IVD (zeige IVD Proteine)) cells and translamellar cross-bridges in ovine and murine IVDs.

  2. Perlecan knockdown altered matrix organization and significantly decreased the stiffness of both chondrocytes and interstitial matrix as a function of age and genotype.

  3. Perlecan is required for the chondrogenic and adipogenic differentiation from SMCs via its regulation of the Sox9 (zeige SOX9 Proteine) and PPARgamma (zeige PPARG Proteine) gene expression, but not for osteogenic differentiation via Runx2 (zeige RUNX2 Proteine)

  4. The reduced deposition of TGF-beta1 (zeige TGFB1 Proteine) observed in the present study would be expected to impact detrimentally on the remodelling and healing capacity of skin in mutant mice compounding on the poor wound-healing properties already reported for perlecan exon 3 null mice due to an inability to signal with FGF-2 (zeige FGF2 Proteine) and promote angiogenic repair processes.

  5. Hspg2 inhibits autophagy to maintain muscle homeostasis in mouse soleus muscle.

  6. Perlecan HS has significant roles in directing the development of posttraumatic OA, potentially via the alteration of FGF/HS/FGFR (zeige FGFR2 Proteine) signaling.

  7. An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage.

  8. LG3, through interactions with alpha2beta1 integrins on recipient-derived cells leading to activation of ERK1/2 and increased migration, favors myointimal thickening

  9. Perlecan binds the clustering molecule gliomedin (zeige GLDN Proteine) and enhances clustering of node of Ranvier components.

  10. perlecan deficiency alters cartilage matrix patterning and, as we now show, coordinately influences bone formation and calcification

HSPG2 Protein Überblick

Protein Überblick

This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and Transthyretin, etc. and plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and Tardive dyskinesia.

Alternative names and synonyms associated with HSPG2

  • heparan sulfate proteoglycan 2 (HSPG2)
  • heparan sulfate proteoglycan 2 (LOC100340334)
  • heparan sulfate proteoglycan 2 (hspg2)
  • heparan sulfate proteoglycan 2 (Hspg2)
  • perlecan (heparan sulfate proteoglycan 2) (Hspg2)
  • AI852380 Protein
  • HSPG Protein
  • HSPG2 Protein
  • Pcn Protein
  • per Protein
  • Plc Protein
  • PRCAN Protein
  • SJA Protein
  • SJS Protein
  • SJS1 Protein

Bezeichner auf Proteinebene für HSPG2

heparan sulfate proteoglycan 2 , perlecan , basement membrane-specific heparan sulfate proteoglycan core protein-like , basement membrane-specific heparan sulfate proteoglycan core protein , endorepellin (domain V region) , perlecan proteoglycan , perlecan (heparan sulfate proteoglycan 2) , HSPG

GENE ID SPEZIES
612371 Canis lupus familiaris
707213 Macaca mulatta
100071701 Equus caballus
100294588 Ovis aries
100340334 Oryctolagus cuniculus
100467831 Ailuropoda melanoleuca
100494785 Xenopus (Silurana) tropicalis
100617792 Monodelphis domestica
3339 Homo sapiens
403440 Canis lupus familiaris
444872 Bos taurus
100517288 Sus scrofa
117511 Rattus norvegicus
15530 Mus musculus
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