Heparanase Proteine (HPSE)

Bezeichnung:
Heparanase Proteine (HPSE)
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Synonyme:
Hep, Hpa, HPA1, Hpr1, HPSE, HPSE1, HSE1, im:7144134
alle Proteine anzeigen Gen GeneID UniProt
HPSE 10855 Q9Y251
HPSE 15442 Q6YGZ1
HPSE 64537 Q71RP1

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Weitere Proteine zu Heparanase Interaktionspartnern

Human Heparanase (HPSE) Interaktionspartner

  1. data suggest that heparanase plays a critical role in NK cell invasion into tumors and thereby tumor progression and metastases.

  2. The heparanase/syndecan1 (zeige SDC1 Proteine) axis in gallbladder carcinoma cells plays an important role in the invasion and metastasis, thus providing a new therapeutic target.

  3. Results show that HPSE is upregulated in human glioma and seems to confer a growth advantage on glioma cells.

  4. under physiological pH and low levels of tissue factor (zeige F3 Proteine), heparanase may exert a non-enzymatic function interacting and activating the inhibitory function of antithrombin (zeige SERPINC1 Proteine).

  5. Heparanase has emerged as a major regulator of cancer by degrading heparan sulfate thereby influencing multiple signaling pathways that control gene expression, syndecan (zeige SDC1 Proteine) shedding and cell behavior. (Review)

  6. The most common HPA genotypes among Saudis were HPA-1 a + b- (75%), HPA-2 a + b- (62%), HPA-3 a + b- (51.5%), HPA-4 a + b- (99%), HPA-5 (zeige ITGA2 Proteine) a + b- (76.5%), HPA-6 a + b- (100%) and HPA-15 a + b + (50%). The prevalent allele among the HPA systems was (a), except in the HPA-15 system where the (b) allele was found in 52% of the subjects.

  7. heparanase activity is increased without changes in superoxide dismutase (zeige SOD1 Proteine) activity in the granulocytes from patients with lupus nephritis and membranous nephropathy

  8. Heparanase up-regulated the expression of the blood coagulation initiator-tissue factor (zeige F3 Proteine) (TF) and interacted with the tissue factor pathway inhibitor (TFPI (zeige TFPI Proteine)) on the cell surface membrane of endothelial and tumor cells, leading to dissociation of TFPI (zeige TFPI Proteine) and resulting in increased cell surface coagulation activity. [review]

  9. Heparanase procoagulant activity predicts post-surgery necrosis.

  10. Suggest heparanase is a promising, novel target for overcoming myeloma resistance to therapy and that targeting heparanase has the potential to prevent relapse in myeloma and possibly other cancers.

Mouse (Murine) Heparanase (HPSE) Interaktionspartner

  1. eNOS (zeige NOS3 Proteine) prevents heparanase induction and the development of proteinuria

  2. Data show that heparanase-1 (HPA-1) induced shedding of heparan sulfate chain from syndecan-1 (SDC-1 (zeige SDC1 Proteine)) facilitated the release of vascular endothelial growth factor C (VEGF-C (zeige VEGFC Proteine)) from SDC-1 (zeige SDC1 Proteine)/VEGF-C (zeige VEGFC Proteine) complex into the medium of hepatocarcinoma cell.

  3. the activation of intestinal heparanase contributes to intestinal injury during early sepsis by facilitating the destruction of mucosal epithelial glycocalyx and promoting inflammatory responses.

  4. Heparanase increases the inflammation in AGEs-stimulated macrophages through activating the RAGE (zeige AGER Proteine)-NF-kappaB (zeige NFKB1 Proteine) pathway. Heparanase driven inflammation from AGEs-stimulated macrophages increases the adherence of glomerular endothelial cells (GEnCs) and augments the permeability of GEnCs.

  5. heparanase contributes to allergen-induced eosinophil recruitment to the lung.

  6. Unfractionated heparin inhibits heparanase, and reverses the activation of NF-kappaB (zeige NFKB1 Proteine) and MAPK P38 (zeige MAPK1 Proteine) signaling pathways to attenuate inflammatory responses induced by sepsis. These results suggest that UFH

  7. Results show a critical role for heparanase in regulating the branching and invasive behavior of normal mammary epithelia which could be the result of its mutually reciprocal feedback with MMP-14 (zeige MMP14 Proteine).

  8. Data suggest a potential mechanism of diabetic enteropathy, which is depending remarkably on syndecan-1 (Sdc1 (zeige SDC1 Proteine)) and -beta-D-glucuronidase (zeige GUSB Proteine) heparanase (HPSE).

  9. Findings identify a dual function for HPSE in malignant melanoma with a protumorigenic extracellular activity and a tumor-suppressive nuclear action.

  10. Studies in heparanase-deficient mice established its contributions to autophagy.

Pig (Porcine) Heparanase (HPSE) Interaktionspartner

  1. These data suggest that porcine reproductive and respiratory syndrome virus activates NF-kappaB (zeige NFKB1 PLURAL_@34956@) and cathepsin L (zeige CTSL PLURAL_@34956@) to upregulate and process heparanase, and then the active heparanase cleaves heparan sulfate, resulting in viral release.

  2. during late gestation, the mRNA and HPSE levels were higher in Meishan placentae than Yorkshire pigs

  3. study of tissue expression profiles, polymorphisms of HPSE and HPSE2 genes and changes of their mRNA levels in porcine alveolar macrophages (PAMs) induced by PRRSV; upon stimulation in healthy piglets with PRRSV, HPSE mRNA was obviously upregulated, while HPSE2 mRNA did not induce a prominent change in PAMs

  4. our results support a critical role for heparanase in the development of vulnerable atherosclerotic plaques

  5. report molecular cloning and characterisation of heparanase mRNA in the porcine placenta throughout gestation.

Cow (Bovine) Heparanase (HPSE) Interaktionspartner

  1. Suggest that high glucose is a potent stimulator of endothelial heparanase secretion.

  2. Lutropin (zeige LHB Proteine) induces a transient increase in HPSE mRNA at specific times after its addition.

Heparanase (HPSE) Protein Überblick

Protein Überblick

Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Heparanase (HPSE)

  • heparanase (HPSE)
  • heparanase (hpse)
  • heparanase (Hpse)
  • heparanase (LOC100101601)
  • Hep Protein
  • Hpa Protein
  • HPA1 Protein
  • Hpr1 Protein
  • HPSE Protein
  • HPSE1 Protein
  • HSE1 Protein
  • im:7144134 Protein

Bezeichner auf Proteinebene für Heparanase Proteine (HPSE)

heparanase , endo-glucoronidase , heparanase-1 , endoglycosidase heparanase , heparanase-like

GENE ID SPEZIES
100061267 Equus caballus
563020 Danio rerio
100145320 Xenopus (Silurana) tropicalis
461206 Pan troglodytes
707583 Macaca mulatta
10855 Homo sapiens
15442 Mus musculus
64537 Rattus norvegicus
100101601 Oryctolagus cuniculus
100721886 Cavia porcellus
608707 Canis lupus familiaris
100271932 Sus scrofa
281230 Bos taurus
373981 Gallus gallus
101118612 Ovis aries
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