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The aim of this study was to compare the levels of electrolytes, inorganic phosphatase, and alkaline phosphatease, acid phosphatase, and beta-glucuronidase.
We produced GUS from a CHO cell line grown in suspension in a 15 L perfused bioreactor and developed a three step purification procedure that yields approximately 99% pure enzyme with a recovery of more than 40%.
the efficacy of a helper-dependent (HD) canine adenovirus (CAV-2 (zeige CAV2 Proteine)) vector harboring a human GUSB expression cassette (HD-RIGIE) in the MPS VII (zeige TH Proteine) dog brain was tested
This assessment demonstrated that although butyrate dramatically increased beta-glucuronidase production in bioreactors, it adversely impacted the mannose-6-phosphorylation of this lysosomal storage diseasestherapeutic enzyme
expression of CES2, UGTA1A1, and GUSB varies in colorectal pathology tissues and that the expression of CES2 is somewhat related to tumor staging.
GUSB and ATP2B4 (zeige ATP2B4 Proteine) have been validated as a reliable gene combination for Cystic Fibrosis Transmembrane Conductance Regulator (zeige CFTR Proteine) gene qPCR data normalization.
Liver disease affects the expression of common HKGs; beta-glucuronidase and splicing factor arginine/serine-rich 4 (zeige SRSF4 Proteine) are the most stable HKGs for studies of gene expression in HCV-infected human liver.
beta-glucuronidase mutations are associated with mucopolysaccharidosis type VII (zeige TH Proteine)
Recombinant adeno (zeige ADORA2A Proteine)-associated virus encoding human GUSB injected into the vitreous humor of young adult MPS VII (zeige TH Proteine) mice increased GUSB activity and reduced lysosomal distension in regions of the thalamus and tectum
beta glucuronidase present in the synovial fluid of rheumatoid arthritis patients, may contribute to the depletion of glycosaminoglycans from cartilage allowing invasion of synovial cells.
Over-expression of beta-glucuronidase was related to the degree of cancer differentiation, but not to lymph node metastasis.
beta-Glucuronidase, a Regulator of Lyme Arthritis Severity, Modulates Lysosomal Trafficking and MMP-9 (zeige MMP9 Proteine) Secretion in Response to Inflammatory Stimuli
GUSB modulates arthritis pathogenesis by preventing accumulation of proinflammatory glycosaminoglycans within inflamed joint tissue.
The Gus plays a role in liver retinoid metabolism.
Missense mutations and models of murine mucopolysaccharidosis type VII (zeige TH Proteine) produced by targeted mutagenesis
data indicate the expression of beta-glucuronidase coordinated with testosterone level in male CBA mice but not C57BL/6 mice
Lysosome storage in the mucopoysaccharidosis type VII (zeige TH Proteine) brain was corrected by injection of an HSV-1 genetic vector and expression of Gusb was assayed. genetic vector
AnxA6 (zeige ANXA6 Proteine) is a novel receptor that mediates the endocytosis of bovine beta-glucuronidase.
This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. There are many pseudogenes of this locus in the human genome.
, Beta-glucuronidase (gusB)
, adipose storage deficiency