XPA Proteine (XPA)

Bezeichnung:
Xeroderma Pigmentosum, Complementation Group A Proteine (XPA)
Auf www.antikoerper-online.de finden Sie aktuell 6 Xeroderma Pigmentosum, Complementation Group A (XPA) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen XPA Antikörper (136) und XPA Kits (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 157 XPA Produkte verfügbar.
Synonyme:
AI573865, CG6358, DhR14, DhXPA, Dmel\\CG6358, dmXPA, dxpa, EG:EG0007.8, XP1, Xpa, xpac, XPA_DROME, xxpa
alle Proteine anzeigen Gen GeneID UniProt
XPA 7507 P23025
Maus XPA XPA 22590 Q64267
Ratte XPA XPA 298074  

Weitere Synonyme anzeigen

XPA Proteine (XPA) nach Spezies

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Am meisten referenzierte XPA Proteine

  1. Human XPA Protein expressed in Escherichia coli (E. coli) - ABIN1098757 : Pan, Lee: UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity. in Cell cycle (Georgetown, Tex.) 2009 (PubMed)

Weitere Proteine zu XPA Interaktionspartnern

Human Xeroderma Pigmentosum, Complementation Group A (XPA) Interaktionspartner

  1. SNP rs10817938 in promoter region associated with poor prognosis of oral squamous cell carcinoma in Chinese Han population

  2. We showed that loss of HERC2 function leads to the accumulation of XPA and BRCA1 in the patient's fibroblasts and generates decreased sensitivity to apoptosis and increased level of DNA repair

  3. Accumulating evidence suggests that XPA and the helicase activity of transcription factor IIH (TFIIH (zeige GTF2H1 Proteine)) cooperate to verify abnormalities in damaged DNA chemistry. (Review)

  4. XPA is a key scaffold protein (zeige HOMER1 Proteine) for human nucleotide excision repair. (Review)

  5. XPA reduction increased cell viability of a bladder cancer cell line RT4, while XPA re-expression decreased the cell viability of RT4 cells. Study suggests that downregulated XPA may promote carcinogenesis of bladder cancer via impairment of DNA repair.

  6. The risk of esophageal squamous cell carcinoma associated with XPA rs-1800975 was determined. A high ESCC risk was found in subjects who carried the homozygous minor allele of XPA, especially in smokers, those in adobe houses, drinkers of salt tea, or those with a family history of cancer. Variant genotypes of both XPA and XPC (zeige XPC Proteine) in combination showed an increased risk towards ESCC.

  7. The role of conformational selection in the molecular recognition of the wild type and mutants XPA67-80 peptides by ERCC1 (zeige ERCC1 Proteine) has been described.

  8. We discovered four new XP-A patients and a novel XPA mutation resulting in two diverse patient alleles.

  9. a specific XPA genotype is associated with mild phenotype in Xeroderma Pigmentosum in United Kingdom immigrants from India, Pakistan, and Afghanistan

  10. Findings suggest that xeroderma pigmentosum complementation group-A (XPA) levels may be a potential predictor of prognosis in locally advanced nasopharyngeal carcinoma (NPC (zeige NPC1 Proteine)) patients treated with platinum-based chemoradiotherapy.

Mouse (Murine) Xeroderma Pigmentosum, Complementation Group A (XPA) Interaktionspartner

  1. The authors' results suggest that lack of the DNA repair factor XPA may delay neurobehavioral recovery after TBI (zeige TBPL1 Proteine)

  2. Oxidized glycerophosphocholines play a pivotal role in the photosensitivity associated with the deficiency of XPA.

  3. The tissue-specific effect of Xpa deficiency represents a novel finding; it suggests that tissue-to-tissue variation in CAG repeat (zeige CELF3 Proteine) instability arises, in part, by different underlying mechanisms.

  4. The circadian oscillation of XPA is achieved both by regulation of transcription by the core circadian clock proteins including cryptochrome and by regulation at the posttranslational level by the HERC2 ubiquitin ligase.

  5. The Xpa/p53 (zeige TP53 Proteine)+/- mouse model is an excellent candidate for a future replacement of the chronic mouse bioassay for certain classes of chemicals.

  6. Xeroderma pigmentosum group A (XPA) gene-deficient mice cannot repair UV-induced DNA damage and easily develop skin cancers by UV irradiation. UVB-induced local and systemic immunosuppression was greatly enhanced in the (-/-) mice.

  7. Enhanced spontaneous and aflatoxin-induced liver tumorigenesis in xeroderma pigmentosum group A gene-deficient mice

  8. XPA (-/-), SCF (zeige KITLG Proteine)-Tg mice did not develop skin cancers after repeated exposures to UVB for 30 wk at a total dose of 72 J per cm(2)

  9. Xpa-/- keratinocytes (complete nucleotide excision repair deficiency) show a rapid depletion of DNA replicating S-phase cells, a transient increase in quiescent S-phase cells (not replicating DNA), followed by massive apoptosis.

  10. The human carcinogen phenacetin acts as a weak genotoxic agent in an in vivo mouse model system in an Xpa deficient model.

XPA Protein Überblick

Protein Überblick

This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with XPA

  • Xeroderma pigmentosum group A-like (Xpac)
  • xeroderma pigmentosum, complementation group A (XPA)
  • xeroderma pigmentosum, complementation group A (Xpa)
  • xeroderma pigmentosum, complementation group A (xpa)
  • AI573865 Protein
  • CG6358 Protein
  • DhR14 Protein
  • DhXPA Protein
  • Dmel\\CG6358 Protein
  • dmXPA Protein
  • dxpa Protein
  • EG:EG0007.8 Protein
  • XP1 Protein
  • Xpa Protein
  • xpac Protein
  • XPA_DROME Protein
  • xxpa Protein

Bezeichner auf Proteinebene für XPA

CG6358-PA , Xpac-PA , xeroderma pigmentosum group A-like , DNA repair protein complementing XP-A cells , excision repair-controlling , xeroderma pigmentosum group A-complementing protein , DNA repair protein complementing XP-A cells homolog , xeroderma pigmentosum group A-complementing protein homolog , xpacch protein , xpacx1 protein

GENE ID SPEZIES
31357 Drosophila melanogaster
7507 Homo sapiens
22590 Mus musculus
395659 Gallus gallus
298074 Rattus norvegicus
397790 Xenopus laevis
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