RAD51C Proteine (RAD51C)

RAD51 Homolog C (S. Cerevisiae) Proteine (RAD51C)
Auf www.antikoerper-online.de finden Sie aktuell 6 RAD51 Homolog C (S. Cerevisiae) (RAD51C) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen RAD51C Antikörper (111) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 124 RAD51C Produkte verfügbar.
ATRAD51C, BROVCA3, CG2412, Dm CG2412, Dmel\\CG2412, F4L23.21, FANCO, R51H3, Rad51c, RAD51L2, RAS associated with diabetes protein 51C, RGD1563765, zgc:101596
alle Proteine anzeigen Gen GeneID UniProt
Ratte RAD51C RAD51C 497976  
RAD51C 114714 Q924H5
RAD51C 5889 O43502

Weitere Synonyme anzeigen

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Weitere Proteine zu RAD51C Interaktionspartnern

Arabidopsis thaliana RAD51 Homolog C (S. Cerevisiae) (RAD51C) Interaktionspartner

  1. AtRAD51C and SWI (zeige SMARCA1 Proteine) may function at distinct stages of meiosis.

  2. AtRAD51C is essential for normal meiosis and is probably required for homologous synapsis.[AtRAD51C]

  3. Crossing of RAD51C mutant with wild-type plants showed defective male and female gametogeneses as evidenced by lack of seed production. Furthermore, meiosis was severely disturbed in the mutant.

Mouse (Murine) RAD51 Homolog C (S. Cerevisiae) (RAD51C) Interaktionspartner

  1. Similar to other BC models, Rad51c/p53 double-mutant mouse mammary tumors also rev (zeige TP53 Proteine)eal a propensity for genomic instability, but lack the focal amplification of the Met locus or distinct mutational signatures reported for other HR genes

  2. a critical synergy between Rad51c and Trp53 (zeige TP53 Proteine) in tumour progression and provide a predictable in vivo model system for studying mechanisms of Rad51c-mediated carcinogenesis

  3. These results imply that adequate expression of Rad51C in mammalian cells is essential for maintaining genomic stability and sister chromatid cohesion to prevent malignant transformation.

  4. the RAD51C-XRCC3-associated Holliday junction resolvase complex associates with crossovers and may play an essential role in the resolution of recombination intermediates prior to chromosome segregation

  5. RAD51C has a late role in meiotic recombination.

  6. Rad51c mutation in DH-cis (zeige CISH Proteine) mice promoted the development of tumors of specialized sebaceous glands and suppressed tumors characteristic of Trp53 (zeige TP53 Proteine) mutation. In addition, DH-cis (zeige CISH Proteine) females developed tumors significantly earlier than any other group.

  7. DNA replication licensing factor MCM2 (zeige MCM2 Proteine) and DNA mismatch repair (MMR (zeige MRC1 Proteine)) protein MSH2 (zeige MSH2 Proteine) were confirmed to be present in co-precipitations with MmRAD51C.

Human RAD51 Homolog C (S. Cerevisiae) (RAD51C) Interaktionspartner

  1. Using the human mammary epithelial cell line MCF10A, we show that deletion of TP53 (zeige TP53 Proteine) can rescue RAD51C-deficient cells from radiation-induced cellular senescence, whereas it exacerbates their centrosome amplification and nuclear abnormalities

  2. Results identified a chromosomal translocation between Rad51C and Ataxin-7 in colorectal tumors. The in-frame fusion transcript results in a fusion protein with molecular weight of 110 KDa. In vitro 5-Azacytidine treatment of colorectal tumor cells showed expression of the fusion gene is regulated by promoter methylation.

  3. Germline mutation in RAD51C gene is associated with neoadjuvant therapy response in triple negative breast patients.

  4. Germline RAD51C mutation was found in patients with hereditary and sporadic gastric cancer.

  5. individuals with mutations in RAD51C that are exposed to estrogen would be more susceptible to accumulation of DNA damage, leading to cancer progression.

  6. Overexpression of RAD51C is associated with resistance to cisplatin and radiation in non-small cell lung cancer.

  7. RAD51C mutations were identified in 0.5 % of Danish families.

  8. RAD51C mutation is not associated with high-risk patients from Serbian hereditary breast/ovarian cancer.

  9. a mutation analysis in 171 high-risk BRCA1 and BRCA2 (zeige BRCA2 Proteine) negative ovarian cancer patients, to evaluate the frequency of hereditary RAD51C and RAD51D (zeige RAD51D Proteine) variants in Czech population, is reported.

  10. Novel Rad51C splice variants occur in colorectal tumors and cells: Variant 1 without exon-7, Variant 2 without exon 6 and 7 , or Variant 3 without exon 7 and 8. They are associated with FANCD2 foci positive colorectal tumors and microsatellite stability.

RAD51C Protein Überblick

Protein Überblick

This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have been identified.

Alternative names and synonyms associated with RAD51C

  • RAD51 homolog C (S. cerevisiae) (RAD51C)
  • RAD51 paralog C (Rad51c)
  • RAD51 paralog C (RAD51C)
  • CG2412 gene product from transcript CG2412-RB (Rad51C)
  • rad51 homolog C (S. cerevisiae) (rad51c)
  • RAD51 paralog C (rad51c)
  • Rad51 DNA recombinase 3 (RAD51C)
  • RAD51C protein (RAD51C)
  • RAD51 homolog C (Rad51c)
  • DNA repair protein RAD51 homolog 3 (RAD51C)
  • ATRAD51C Protein
  • BROVCA3 Protein
  • CG2412 Protein
  • Dm CG2412 Protein
  • Dmel\\CG2412 Protein
  • F4L23.21 Protein
  • FANCO Protein
  • R51H3 Protein
  • Rad51c Protein
  • RAD51L2 Protein
  • RAS associated with diabetes protein 51C Protein
  • RGD1563765 Protein
  • zgc:101596 Protein

Bezeichner auf Proteinebene für RAD51C

Rad51 homolog c , RAD51 homolog C , CG2412-PB , Rad51C-PB , RAD51 homolog C (S. cerevisiae) , DNA repair protein RAD51 homolog 3 , Rad51 DNA recombinase 3 , RAD51C protein , RAD51-like protein 2 , yeast RAD51 homolog 3

480573 Canis lupus familiaris
497976 Rattus norvegicus
540886 Bos taurus
100070966 Equus caballus
100518577 Sus scrofa
35937 Drosophila melanogaster
417626 Gallus gallus
450081 Danio rerio
455162 Pan troglodytes
548416 Xenopus (Silurana) tropicalis
714828 Macaca mulatta
8250454 Micromonas sp. RCC299
9681081 Micromonas pusilla CCMP1545
100192184 Triticum aestivum
100286824 Nasonia vitripennis
100339674 Oryctolagus cuniculus
100583086 Nomascus leucogenys
819136 Arabidopsis thaliana
114714 Mus musculus
5889 Homo sapiens
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