RAD51 Proteine (RAD51)

DNA Repair Protein Homolog 1 Proteine (RAD51)
Auf www.antikoerper-online.de finden Sie aktuell 13 DNA Repair Protein Homolog 1 (RAD51) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen RAD51 Antikörper (207) und RAD51 Kits (6) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 247 RAD51 Produkte verfügbar.
4921524O04Rik, 8030409M04Rik, ATRAD51, AV304093, brcc5, CRAD51, F22D1.20, F22D1_20, HRAD51, HsRad51, HsT16930, MRMV2, rad51, rad51a, RAS associated with diabetes protein 51, reca, RGD1563603, wu:fb38e12, xrad51, zgc:77754
alle Proteine anzeigen Gen GeneID UniProt
RAD51 57434 Q9CX47
RAD51 5888 Q06609
Ratte RAD51 RAD51 499870  

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Am meisten referenzierte RAD51 Proteine

  1. Human RAD51 Protein expressed in Escherichia coli (E. coli) - ABIN2452204 : Kurumizaka, Aihara, Kagawa, Shibata, Yokoyama: Human Rad51 amino acid residues required for Rad52 binding. in Journal of molecular biology 1999 (PubMed)
    Zeige alle 2 Referenzen für 2452204

  2. Human RAD51 Protein expressed in Wheat germ - ABIN1317281 : De, Donahue, Tabah, Castro, Mraz, Cruise, Campbell: A novel interaction [corrected] of nucleolin with Rad51. in Biochemical and biophysical research communications 2006 (PubMed)

Weitere Proteine zu RAD51 Interaktionspartnern

Mouse (Murine) DNA Repair Protein Homolog 1 (RAD51) Interaktionspartner

  1. involvement of ZNF281 (zeige ZNF281 Proteine) in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms

  2. Our results thus help establish the functional relevance of the trimeric RAD51-SWI5 (zeige SWI5 Proteine)-SFR1 (zeige SFR1 Proteine) complex and provide insights into the mechanistic underpinnings of homology-directed DNA repair in mammalian cells.

  3. Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 and 53BP1 (zeige TP53BP1 Proteine) were recruited to these sites. H2AX (zeige H2AFX Proteine) was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX (zeige H2AFX Proteine) foci formation and DSB repair, whereas H2AX (zeige H2AFX Proteine) was barely stabilized in response to secondary DSBs, in which gammaH2AX (zeige H2AFX Proteine) foci were small and DSBs were not efficiently repaired

  4. HOP2 (zeige PSMC3IP Proteine)-MND1 (zeige MND1 Proteine) enhances the interaction of RAD51 with nucleotide cofactors and modifies its DNA-binding specificity.

  5. Rad51 repaired DNA damage.

  6. BRCA2 (zeige BRCA2 Proteine)-mediated sequestration of nuclear RAD51 serves to prevent inappropriate DNA interactions.

  7. increased Rad51 concentration and homology length interact synergistically to promote 3' extension, presumably as a result of enhanced Brca2 (zeige BRCA2 Proteine)-mediated Rad51 polymerization

  8. Results suggest that cellular levels of Brca2 (zeige BRCA2 Proteine) and Rad51 are mutually dependent on each other, and that low levels of these proteins provide selective pressure for reduction of p53 (zeige TP53 Proteine), which permits cell growth

  9. FBH1 restraining RAD51 DNA binding under unperturbed growth conditions to prevent unwanted or unscheduled DNA recombination.

  10. HELQ (zeige HEL308 Proteine) interacts directly with the RAD51 paralogue complex BCDX2 and functions in parallel to the Fanconi anaemia pathway to promote efficient homologous recombination at damaged replication forks

Arabidopsis thaliana DNA Repair Protein Homolog 1 (RAD51) Interaktionspartner

  1. The authors find that RBR1 is also required for RAD51 localization to DNA lesions.

  2. RAD51 forms a protein complex with AtRAD51C (zeige RAD51C Proteine)-AtXRCC3 to facilitate RAD51 localization on chromosomes for meiotic recombination.

  3. Our data demonstrate that RAD51 plays a supporting role for DMC1 (zeige DMC1 Proteine) in meiotic recombination in the flowering plant, Arabidopsis.

  4. The present study demonstrates for the first time the involvement of a host RAD51 protein in mungbean yellow mosaic India virus replication.

  5. Results demonstrate that DMC1 functions independently and spatially separated from RAD51 during meiosis and that ATR is an integral part of the regular meiotic program.

  6. Establishment and stabilisation of pairing of homologous centromeric and pericentromeric regions depends principally upon DMC1 (zeige DMC1 Proteine), while pairing and synapsis of euchromatic chromosome arms of homologues requires the presence of RAD51

  7. AtRAD51 is required to ensure the fidelity of homologous recombination during interchromosomal exchanges. It may also be required to ensure the fidelity of homologous recombination in the interchromosomal exchanges initiated by AtDMC1.

  8. AtBRCA2 is required for proper meiotic synapsis and mediates the recruitment of AtRAD51 and AtDMC1.

  9. Study provides the molecular evidence showing that the BRCA2 (zeige BRCA2 Proteine)-RAD51 complex, known for its function in HR, also plays a direct and specific role in transcription regulation during plant immune responses.

  10. results show that loss of RAD51 caused hypersensitivity to the double-strand break-inducing agent bleomycin in P. patens but not Arabidopsis; data show importance of RAD51 for viability is independent of taxonomic position or complexity of an organism

Pig (Porcine) DNA Repair Protein Homolog 1 (RAD51) Interaktionspartner

  1. The complete cDNA sequences of the pig RAD51, RAD52 (zeige RAD52 Proteine), and RAD54 (zeige RAD54L Proteine) genes, which are closely related to homologous recombination events, arae identified using molecular cloning technique in pigs.

Cow (Bovine) DNA Repair Protein Homolog 1 (RAD51) Interaktionspartner

  1. Meiosis progression and female age affect expression profile of DNA repair RAD51 gene in bovine oocytes.

  2. RAD51 plays a crucial role in halting cell death program induced by ionizing radiation in bovine oocytes.

Human DNA Repair Protein Homolog 1 (RAD51) Interaktionspartner

  1. By antagonizing RAD51 at forks, RADX allows cells to maintain a high capacity for homology-directed repair while ensuring that replication functions of RAD51 are properly regulated. Thus, RADX is essential to achieve the proper balance of RAD51 activity to maintain genome stability.

  2. E3 ligase RFWD3 (zeige RFWD3 Proteine) functions in timely removal and degradation of RPA (zeige RPA1 Proteine) and RAD51 to allow homologous recombination progression to subsequent steps following mitomycin C damage.

  3. In the absence of RAD51, the unprotected newly replicated genome is degraded by the exonuclease (zeige EXO1 Proteine) activity of MRE11 (zeige MRE11A Proteine), and the fragmented nascent DNA accumulates in the cytosol, initiating an innate immune response.

  4. Architectural plasticity of human BRCA2 (zeige BRCA2 Proteine)-RPA (zeige RPA1 Proteine)-RAD51 complexes in DNA break repair has been described.

  5. cyclin D1 (zeige CCND1 Proteine) and other cyclins such as cyclin A (zeige CCNA2 Proteine) regulates DNA integrity through RAD51 interaction with the BRCA2 (zeige BRCA2 Proteine) C-terminal domain

  6. Upregulation of RAD51 and overexpression of Ki67 (zeige MKI67 Proteine) may be associated with the progression of thyroid cancer.

  7. The data suggest that Rad51 overexpression is correlated with malignant phenotypes of colorectal cancer and may predict poor prognosis for these patients.

  8. Data suggest that RAD51, BRCA2 (zeige BRCA2 Proteine), and BRCA1 promote stability of nascent DNA at replication forks; RAD51 prevents MRE11 (zeige MRE11A Proteine) nuclease (zeige DCLRE1C Proteine)-mediated degradation of nascent ssDNA; BRCA2 (zeige BRCA2 Proteine) displaces RPA (zeige RPA1 Proteine) (replication protein A (zeige GPR153 Proteine)) complex by recruiting RAD51 to protect ssDNA; BRCA1 promotes repair foci following DNA damage and is essential for cell survival. (BRCA = breast cancer recombination protein; RAD51 = Rad51 recombinase (zeige RAG1 Proteine)) [REVIEW]

  9. Data suggest RAD52 (zeige RAD52 Proteine) binds tightly to RPA (zeige RPA1 Proteine)/ssDNA complex in presynaptic complex and inhibits RPA (zeige RPA1 Proteine) turnover; during presynaptic complex assembly, most of RPA (zeige RPA1 Proteine) and RAD52 (zeige RAD52 Proteine) is displaced from ssDNA, but some RAD52 (zeige RAD52 Proteine)/RPA (zeige RPA1 Proteine)/ssDNA complexes persist as interspersed clusters surrounded by RAD51 filaments. (RAD52 (zeige RAD52 Proteine) = Rad52 (zeige RAD52 Proteine) DNA repair/recombination protein (zeige RAD50 Proteine); RPA (zeige RPA1 Proteine) = replication protein A (zeige GPR153 Proteine); ssDNA = single-stranded DNA; RAD51 = Rad51 recombinase (zeige RAG1 Proteine))

  10. High RAD51 expression is associated with drug Resistance in Malignant Melanoma.

Xenopus laevis DNA Repair Protein Homolog 1 (RAD51) Interaktionspartner

  1. Brca2 (zeige BRCA2 Proteine) and Rad51 prevent formation of abnormal DNA replication intermediates, whose processing by Smarcal1 (zeige SMARCAL1 Proteine) and Mre11 (zeige MRE11A Proteine) predisposes to genome instability.

  2. Data show that MRE11- and RAD51-dependent fork repair leading to reloading of the GINS onto the MCM-CDC45 complex still engaged with the DNA could be sufficient to restore a functional CDC45-MCM-GINS (CMG) helicase complex.

  3. By promoting CtIP (zeige RBBP8 Proteine)-dependent resection of double-strand break (DSB) ends while preventing Rad51 chromatin assembly, Cdk1 (zeige CDK1 Proteine) inhibits both the nonhomologous and homologous modes of DSB repair during mitosis.

  4. Rad51 has a role at the replication fork protecting DNA from Mre11 (zeige MRE11A Proteine)-dependent degradation.

RAD51 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with RAD51

  • X-ray repair complementing defective repair in Chinese hamster cells 2 (Xrcc2)
  • DNA repair protein RAD51-like 1 (RAD51)
  • RAD51 homolog (Rad51)
  • RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) (rad51)
  • RAD51 homolog (S. cerevisiae) (RAD51)
  • RAD51 homolog (S. cerevisiae) (Rad51)
  • RAD51 recombinase (RAD51)
  • RAD51 recombinase (Rad51)
  • RAD51 recombinase (rad51-a)
  • 4921524O04Rik Protein
  • 8030409M04Rik Protein
  • ATRAD51 Protein
  • AV304093 Protein
  • brcc5 Protein
  • CRAD51 Protein
  • F22D1.20 Protein
  • F22D1_20 Protein
  • HRAD51 Protein
  • HsRad51 Protein
  • HsT16930 Protein
  • MRMV2 Protein
  • rad51 Protein
  • rad51a Protein
  • RAS associated with diabetes protein 51 Protein
  • reca Protein
  • RGD1563603 Protein
  • wu:fb38e12 Protein
  • xrad51 Protein
  • zgc:77754 Protein

Bezeichner auf Proteinebene für RAD51

DNA repair protein XRCC2 , X-ray repair cross-complementing protein 2 , recA/RAD51 family protein , DNA repair protein RAD51 homolog 1 , RAD51 homolog A , RAD51 homolog (RecA homolog, E. coli) , homolog to S.cerevisiae , DNA repair protein RAD51 , DNA repair protein RAD51-like 1 , BRCA1/BRCA2-containing complex, subunit 5 , RecA, E. coli, homolog of , RecA-like protein , recombination protein A , RAD51 homolog , DNA repair protein RAD51 homolog A , RAD51 homolog (RecA homolog) , XRad51.1

57434 Mus musculus
832208 Arabidopsis thaliana
19361 Mus musculus
406487 Danio rerio
396086 Gallus gallus
403568 Canis lupus familiaris
100141309 Sus scrofa
514749 Bos taurus
100008661 Oryctolagus cuniculus
100689324 Cricetulus griseus
5888 Homo sapiens
499870 Rattus norvegicus
397726 Xenopus laevis
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