RAD23 Homolog B (S. Cerevisiae) Proteine (RAD23B)

RAD23 Homolog B (S. Cerevisiae) Proteine (RAD23B)
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0610007D13Rik, AV001138, HHR23B, HR23B, MGC107846, mHR23B, p58, zgc:65951
alle Proteine anzeigen Gen GeneID UniProt
RAD23B 5887 P54727
RAD23B 298012 Q4KMA2
RAD23B 19359 P54728

Weitere Synonyme anzeigen

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Am meisten referenzierte RAD23 Homolog B (S. Cerevisiae) Proteine

  1. Human RAD23B Protein expressed in Wheat germ - ABIN1317279 : Chen, Lin, Chow, Lee: Proteomic identification of Hsp70 as a new Plk1 substrate in arsenic trioxide-induced mitotically arrested cells. in Proteomics 2011 (PubMed)

Weitere Proteine zu RAD23 Homolog B (S. Cerevisiae) Interaktionspartnern

Human RAD23 Homolog B (S. Cerevisiae) (RAD23B) Interaktionspartner

  1. XPC (zeige XPC Proteine) dissociation from the damage site could become a rate-limiting step in nucleotide excision repair (NER (zeige NR1H2 Proteine)) of certain types of DNA adducts, leading to repression of NER (zeige NR1H2 Proteine).

  2. HR23B role in DNA reapair, in protein degradation and stability, tumorigenesis and neurodegenerative disorders [review]

  3. Data show that nucleotide excision repair factor XPC (zeige XPC Proteine)-RAD23B is a target of poly(ADP-ribosyl)ation catalyzed by poly(ADP-ribose) polymerase 1 (PARP1 (zeige PARP1 Proteine)).

  4. RAD23B has a potential role in breast cancer progression and a tumor suppressor role of nuclear RAD23B in breast cancer.

  5. It is unlikely that the RAD23B 249Val/Val polymorphism may contribute to the individual susceptibility to cancer risk.

  6. Results define a regulatory mechanism that involves the interplay between HR23B and HDAC6 (zeige HDAC6 Proteine) that influences the biological outcome of HDAC (zeige HDAC3 Proteine) inhibitor treatment.

  7. Polymorphism in RAD23B gene is associated with breast cancer.

  8. HR23B expression was associated with disease stabilization for patients with unresectable hepatocellular carcinoma treated with epigenetic therapy using belinostat, a histone deacetylase (zeige HDAC1 Proteine) inhibitor.

  9. Single nucleotide polymorphisms of CCND2 (zeige CCND2 Proteine), RAD23B, GRP78 (zeige HSPA5 Proteine), CEP164, MDM2 (zeige MDM2 Proteine), and ALDH2 (zeige ALDH2 Proteine) genes were significantly associated with development and recurrence of hepatocellular carcinoma in Japanese patients with hepatitis C virus.

  10. PNGase (zeige NGLY1 Proteine)-PUB serves not only as p97 (zeige EIF4G2 Proteine)-binding module but also as a possible activator of HR23 in endoplasmic reticulum-associated degradation mechanisms.

Mouse (Murine) RAD23 Homolog B (S. Cerevisiae) (RAD23B) Interaktionspartner

  1. the mammalian RAD23 proteins play a direct role in damage recognition by enhancing the binding of XPC (zeige XPC Proteine) to DNA damage in living cells in addition to stabilizing XPC (zeige XPC Proteine). RAD23 proteins rapidly dissociated from XPC (zeige XPC Proteine) upon binding to damaged DNA.

  2. analysis of mHR23A (zeige RAD23A Proteine)/B double-mutant cells showed that HR23 proteins function in nucleotide excision repair by governing xeroderma pigmentosum group C protein (zeige HNRNPC Proteine) stability via partial protection against proteasomal degradation

  3. The crystal structure of the mouse peptide N-glycanase catalytic core in complex with the xeroderma pigmentosum group C binding domain from HR23B is described; the results suggest a co-evolution of ER-associated degradation and DNA repair pathways.

  4. This illustrates that impairment of the ubiquitin-proteasome system (UPS) by expanded glutamine (zeige GFPT1 Proteine) repeats, including the sequestration of HR23B, is not affecting NER (zeige NR1H2 Proteine).

RAD23 Homolog B (S. Cerevisiae) (RAD23B) Protein Überblick

Protein Überblick

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Alternative names and synonyms associated with RAD23 Homolog B (S. Cerevisiae) (RAD23B)

  • UV excision repair protein RAD23 homolog B (rd23b)
  • UV excision repair protein RAD23 homolog B (LOC100353489)
  • RAD23 homolog B (S. cerevisiae) (RAD23B)
  • RAD23 homolog B (rad23b)
  • RAD23 homolog B (S. cerevisiae) (Rad23b)
  • RAD23 homolog B (S. cerevisiae) (rad23b)
  • RAD23b homolog (S. cerevisiae) (Rad23b)
  • 0610007D13Rik Protein
  • AV001138 Protein
  • HHR23B Protein
  • HR23B Protein
  • MGC107846 Protein
  • mHR23B Protein
  • p58 Protein
  • zgc:65951 Protein

Bezeichner auf Proteinebene für RAD23B

UV excision repair protein RAD23 homolog B , RAD23 homolog B (S. cerevisiae) , RAD23 homolog B , RAD23, yeast homolog of, B , XP-C repair complementing complex 58 kDa , XP-C repair complementing protein , XP-C repair-complementing complex 58 kDa protein , RAD23b homolog , HR23B

100306736 Salmo salar
100353489 Oryctolagus cuniculus
431623 Gallus gallus
594966 Xenopus (Silurana) tropicalis
697049 Macaca mulatta
711328 Macaca mulatta
100022113 Monodelphis domestica
100059968 Equus caballus
100581563 Nomascus leucogenys
398507 Xenopus laevis
5887 Homo sapiens
298012 Rattus norvegicus
473012 Pan troglodytes
481656 Canis lupus familiaris
393536 Danio rerio
530189 Bos taurus
19359 Mus musculus
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