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Polymerase (DNA Directed), eta Proteine (POLH)

Bezeichnung:
Polymerase (DNA Directed), eta Proteine (POLH)
Auf www.antikoerper-online.de finden Sie aktuell 5 Polymerase (DNA Directed), eta (POLH) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Polymerase (DNA Directed), eta Antikörper (51) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 59 Polymerase (DNA Directed), eta Produkte verfügbar.
Synonyme:
fc50a12, POLH, RAD30, RAD30A, wu:fc50a12, XP-V, XPV, zgc:136881, zgc:152642
alle Proteine anzeigen Gen GeneID UniProt
POLH 5429 Q9Y253
Ratte POLH POLH 316235  
POLH 80905 Q9JJN0

Weitere Synonyme anzeigen

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Weitere Proteine zu Polymerase (DNA Directed), eta Interaktionspartnern

Xenopus laevis Polymerase (DNA Directed), eta (POLH) Interaktionspartner

  1. Error-free insertion in cyclobutane pyrimidine bypass is due mainly to pol eta (translesion synthesis TLS3) in oocyte extracts during DNA replication.

Human Polymerase (DNA Directed), eta (POLH) Interaktionspartner

  1. Study shows that the posttranslational modifications of nuclear localization signal of pol eta played a dual role in polymerase switching, where Lys682 deubiquitination promotes the recruitment of pol eta to PCNA (zeige PCNA Proteine) immediately prior to lesion bypass and Ser687 phosphorylation stimulates its departure from the replication fork immediately after lesion bypass.

  2. The data directly show that, in the human genome, DNA Pol-eta and Rev1 bypass cyclobutane pyrimidine dimers and 6-4PP at replication forks, while only 6-4PP are also tolerated by a Rev3L-dependent gap-filling mechanism, independent of S phase.

  3. p53 (zeige TP53 Proteine) controls the induction of DNA polymerase eta in DNA damaged human cells. The role of DNA polymerase eta in p53 (zeige TP53 Proteine)-dependent translesion synthesis.

  4. These results provide important knowledge about the effects of the length and structure of the alkyl group in O(4)-alkylthymidine lesions on the fidelity and efficiency of DNA replication mediated by human DNA polymerase eta.

  5. The described is cooperative motion of a key positively charged residue and metal ions for DNA replication catalyzed by human DNA Polymerase eta.

  6. free energy difference is slightly greater for binding at the 5' thymine position than at the 3' thymine position, presumably because of stabilization arising from the A:T base pair formed at the 3' position of the TTD in previous step of Pol eta function

  7. PolH721 variant present in XP-V patients is unstable. Extra 8 amino acids of PolH721 do not act as degron but induce conformational change of PolH C-terminus exposing its bipartite NLS and sequence close to its UBZ to the ubiquitin/proteasome system.

  8. Poleta has three PCNA (zeige PCNA Proteine)-interacting protein (PIP (zeige PIP Proteine)) boxes (PIP1 (zeige PAK1IP1 Proteine), 2, 3) that contribute differentially to two distinct functions, stimulation of DNA synthesis and promotion of PCNA (zeige PCNA Proteine) ubiquitination.

  9. our findings reveal a modulatory role of USP7 (zeige USP7 Proteine) in PCNA (zeige PCNA Proteine) ubiquitination-mediated stress-tolerance pathways by fine-tuning Poleta turnover.

  10. Arg-61 and Gln-38 of human DNA polymerase (zeige POLB Proteine) (hpol) eta play important roles in the catalytic reaction.

Mouse (Murine) Polymerase (DNA Directed), eta (POLH) Interaktionspartner

  1. the functions of REV3L in maintaining cell viability, embryonic viability and genomic stability are directly dependent on its polymerase activity, and cannot be ameliorated by an additional deletion of pol eta.

  2. XP-V has a role in adipose tissue senescence and metabolic syndrome

  3. Increase in UV-induced mutations at both G:C and A:T pairs associated with PolH deficiency suggests that PolH contributes to accurate translesion synthesis (TLS (zeige FUS Proteine)) past both T- & C-containing dimers.

  4. POLH deficiency did not affect the frequency and patterns of C:G mutations and UNG (zeige UNG Proteine) POLH double deficiency showed an additive effect of single deficiency.

  5. REV1 and Polkappa are involved in DNA damage tolerance via Poleta-REV1 interaction when Poleta fails to bypass its cognate substrates.

  6. These results reveal genetic interactions between REV1 catalytic activity and POLH and identify an alternative pathway in the generation of C to G and G to C transversions.

  7. these data support the existence of PCNA (zeige PCNA Proteine) ubiquitination-dependent and -independent activation pathways of Poleta during somatic hypermutation and DNA damage tolerance.

  8. inaccurate DNA synthesis by mammalian DNA polymerase eta (pol eta) contributes to somatic hypermutation (SHM (zeige CNTNAP1 Proteine)) of Ig genes

  9. suggest the involvement of the Pol eta and Pol iota (zeige POLI Proteine) proteins in UV-induced skin carcinogenesis

  10. Results reveal genetic and biochemical interactions between DNA polymerases eta (POLH) and theta (POLQ) and suggest that POLQ might cooperate with POLH to generate some of the A/T mutations during the somatic hypermutation of Ig genes.

Polymerase (DNA Directed), eta (POLH) Protein Überblick

Protein Überblick

This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA\; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum.

Alternative names and synonyms associated with Polymerase (DNA Directed), eta (POLH)

  • polymerase (DNA directed), eta (polh)
  • polymerase (DNA directed), eta (POLH)
  • DNA polymerase eta (Tb10.70.6190)
  • DNA polymerase eta (LinJ21.0530)
  • polymerase (DNA directed), eta (Polh)
  • polymerase (DNA directed), eta (RAD 30 related) (Polh)
  • fc50a12 Protein
  • POLH Protein
  • RAD30 Protein
  • RAD30A Protein
  • wu:fc50a12 Protein
  • XP-V Protein
  • XPV Protein
  • zgc:136881 Protein
  • zgc:152642 Protein

Bezeichner auf Proteinebene für POLH

DNA-directed DNA polymerase eta , DNA polymerase eta , polymerase (DNA directed), eta , DNA polymerase eta-like , polymerase eta , RAD30 homolog A , xeroderma pigmentosum variant type protein , polymerase (DNA directed), eta (RAD 30 related) , xeroderma pigmentosum variant type protein homolog

GENE ID SPEZIES
446909 Xenopus laevis
462720 Pan troglodytes
474915 Canis lupus familiaris
513606 Bos taurus
678520 Danio rerio
700772 Macaca mulatta
3661974 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5068792 Leishmania infantum JPCM5
100011953 Monodelphis domestica
100067518 Equus caballus
100124112 Nasonia vitripennis
100357494 Oryctolagus cuniculus
100392158 Callithrix jacchus
100443019 Pongo abelii
100473341 Ailuropoda melanoleuca
395102 Gallus gallus
100558919 Anolis carolinensis
100602084 Nomascus leucogenys
5429 Homo sapiens
316235 Rattus norvegicus
80905 Mus musculus
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