POLH Protein (Myc-DYKDDDDK Tag)

Produktnummer ABIN2729308

Produktdetails

Target: POLH (Polymerase (DNA Directed), eta (POLH))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses POLH Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human POLH / RAD30 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: POLH (Polymerase (DNA Directed), eta (POLH))

Andere Bezeichnung: Polh,rad30 (POLH Produkte)

Synonyme: POLH Protein, fc50a12 Protein, wu:fc50a12 Protein, zgc:136881 Protein, zgc:152642 Protein, RAD30 Protein, RAD30A Protein, XP-V Protein, XPV Protein, polymerase (DNA directed), eta S homeolog Protein, DNA polymerase eta Protein, polymerase (DNA directed), eta Protein, putative DNA polymerase eta Protein, polymerase (DNA directed), eta (RAD 30 related) Protein, polh.S Protein, POLH Protein, polh Protein, Tb10.70.6190 Protein, LINJ_21_0690 Protein, Polh Protein, LOC100443019 Protein

Hintergrund: This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 78.2 kDa

NCBI Accession: NP_006493

Pathways: DNA Reparatur