anti-POLE (POLE) Antikörper

anti-Polymerase (DNA Directed), Epsilon, Catalytic Subunit Antikörper (POLE)
Auf finden Sie aktuell 41 Polymerase (DNA Directed), Epsilon, Catalytic Subunit (POLE) Antikörper von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 43 POLE Produkte verfügbar.
Alle Antikörper anzeigen Gen GeneID UniProt
POLE 18973 Q9WVF7
POLE 5426 Q07864

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Weitere Synonyme anzeigen

Meistgesuchte Reaktivitäten zu anti-POLE (POLE) Antikörper

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anti-Mouse (Murine) POLE Antikörper:

anti-Human POLE Antikörper:

anti-Mustelid POLE Antikörper:

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Am meisten referenzierte anti-POLE Antikörper

  1. Human Monoclonal POLE Primary Antibody für ICC, IF - ABIN151041 : Maga, Jónsson, Stucki, Spadari, Hübscher: Dual mode of interaction of DNA polymerase epsilon with proliferating cell nuclear antigen in primer binding and DNA synthesis. in Journal of molecular biology 1999 (PubMed)
    Zeige alle 12 Referenzen für 151041

  2. Cow (Bovine) Monoclonal POLE Primary Antibody für IP, WB - ABIN180370 : Uitto, Halleen, Hentunen, Höyhtyä, Syväoja: Structural relationship between DNA polymerases epsilon and epsilon* and their occurrence in eukaryotic cells. in Nucleic acids research 1995 (PubMed)

Weitere Antikörper gegen POLE Interaktionspartner

Mouse (Murine) Polymerase (DNA Directed), Epsilon, Catalytic Subunit (POLE) Interaktionspartner

  1. A missense mutation in Rev7 (zeige MAD2L2 Antikörper) disrupts formation of Polzeta, impairing mouse development and repair of genotoxic agent-induced DNA lesions.

Human Polymerase (DNA Directed), Epsilon, Catalytic Subunit (POLE) Interaktionspartner

  1. Germline or somatic variants in the POLE/POLD1 (zeige POLD1 Antikörper) were identified in unresolved suspected Lynch syndrome cancers with mismatch repair defect.

  2. In colorectal cancers, mutations in the FBXW7 gene were more common in the younger cohort (27.5% vs 9.7%; P = .0022) as were mutations in the proofreading domain of polymerase epsilon catalytic subunit (POLE) (9.8% vs 1%; P = .0048).

  3. POLE ultra-mutated endometrial-carcinomas are heavily infiltrated with CD4 (zeige CD4 Antikörper)+/CD8 (zeige CD8A Antikörper)+ TIL (zeige TLR1 Antikörper), overexpress PD-1 (zeige PDCD1 Antikörper) immune-check-point, and have a better prognosis when compared to other molecular subtypes of endometrial-carcinomas patients. POLE-mutated tumor-cell lines are resistant to platinum-chemotherapy in-vitro suggesting that the better prognosis of POLE-patients is not secondary to a higher sensitivity to ch

  4. Tumors with POLE EDMs had the most favorable prognosis, and those with p53 (zeige TP53 Antikörper) abn the worst prognosis, and separation of the 2 middle survival curves (p53 (zeige TP53 Antikörper) wt and MMR (zeige MRC1 Antikörper)-D) was observed

  5. POLE1 is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 (zeige CIAO1 Antikörper) and MMS19 (zeige MMS19 Antikörper).

  6. study of complete exonuclease (zeige EXO1 Antikörper) domains of POLE and POLD1 (zeige POLD1 Antikörper) in 529 families characterized by presence of familial or early-onset mismatch repair proficient colorectal cancer, and/or APC (zeige APC Antikörper)-negative and MUTYH (zeige MUTYH Antikörper)-negative polyposis; results widen the phenotypic spectrum of the POLE/POLD1 (zeige POLD1 Antikörper)-associated syndrome and identify novel pathogenic variants

  7. Study identified a high penetrant duplication in the regulatory region of GREM1 (zeige GREM1 Antikörper), predisposing to colorectal cancer (CRC (zeige CALR Antikörper)) in a family with attenuated/ atypical polyposis. A POLE variant was also identified in a patient with early onset CRC (zeige CALR Antikörper).

  8. Mutations in POLE and POLD1 (zeige POLD1 Antikörper) in south east Asia women with grade 3 endometrioid endometrial carcinomas are associated with improved recurrence free survival.

  9. None of the 1188 patients carried the POLD1 (zeige POLD1 Antikörper) p.(Ser478Asn) variant. POLE germline variant carriers are also associated with a microsatellite instable colorectal cancer

  10. Results show that that mutated POLE 1 are associated with high neoantigen loads and may be excellent candidates for PD-1 (zeige PDCD1 Antikörper)-targeted immunotherapies.

POLE Antigen-Profil

Beschreibung des Gens

Participates in DNA repair and in chromosomal DNA replication.

Alternative names and synonyms associated with POLE

  • polymerase (DNA directed), epsilon (Pole) Antikörper
  • polymerase (DNA directed), epsilon, catalytic subunit (POLE) Antikörper
  • CRCS12 Antikörper
  • FILS Antikörper
  • POLE1 Antikörper

Bezeichner auf Proteinebene für POLE

DNA polymerase II subunit A , DNA polymerase epsilon catalytic subunit A , DNA-directed DNA polymerase epsilon , pol-epsilon

18973 Mus musculus
5426 Homo sapiens
Ausgewählte Anbieter für anti-POLE (POLE) Antikörper
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