POLB Proteine (POLB)

Bezeichnung:
Polymerase (DNA Directed), beta Proteine (POLB)
Auf www.antikoerper-online.de finden Sie aktuell 14 Polymerase (DNA Directed), beta (POLB) Proteine von 7 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen POLB Antikörper (100) und POLB Kits (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 127 POLB Produkte verfügbar.
Synonyme:
A430088C08Rik, DDBDRAFT_0186152, DDBDRAFT_0215784, DDBDRAFT_0232376, DDB_0186152, DDB_0215784, DDB_0232376, POLB, wu:fa97a05, zgc:109924
alle Proteine anzeigen Gen GeneID UniProt
POLB 5423 P06746
POLB 18970 Q8K409
POLB 29240 P06766

Weitere Synonyme anzeigen

POLB Proteine (POLB) nach Spezies

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Am meisten referenzierte POLB Proteine

  1. Human POLB Protein expressed in Escherichia coli (E. coli) - ABIN667538 : Bambara, Jessee: Properties of DNA polymerases delta and epsilon, and their roles in eukaryotic DNA replication. in Biochimica et biophysica acta 1991 (PubMed)
    Zeige alle 2 Referenzen für 667538

Weitere Proteine zu POLB Interaktionspartnern

Zebrafish Polymerase (DNA Directed), beta (POLB) Interaktionspartner

  1. DNA polymerase beta is sensitive to Mn2+ and Mg2 (zeige MCOLN1 Proteine)+ and its optimumal pH is 9.

  2. In brief, the major differences in BER performed by early stage embryos and adults are the absence of DNA polymerase-beta, leading to predominance of replicative polymerases, in early stage embryos.

Human Polymerase (DNA Directed), beta (POLB) Interaktionspartner

  1. Remote mutations induce functional changes in active site residues of human DNA polymerase beta.

  2. It has been concluded based on calculations and the experimental pH profile that the most likely path for the wild-type (WT) and the D256E and D256A mutants is a proton transfer (PT) to the bulk, although the WT may also use a PT to Asp (zeige ASIP Proteine) 256.

  3. The homozygous/heterozygous genotypes containing the African allele showed higher POLB expression than the homozygous white allele genotype (P < .001). A replication study using a GEO data set validated all 5 eQTLs and also showed a statistically significant difference in POLB expression based on genetic ancestry (P = .002).

  4. HMGB1 (zeige HMGB1 Proteine) stimulates activity of DNA polymerase beta on nucleosome substrates in the process of base excision repair.

  5. The results help to define the tolerance of DNA Pol beta to subtle local structural and functional alterations derived from lysine 72.

  6. HSP90 (zeige HSP90 Proteine) regulates DNA repair by interaction between XRCC1 (zeige XRCC1 Proteine) and DNA polymerase beta.

  7. Data did not detect any significant association with SNPs of APRIL, SPATA8, PDGFRA, and POLB with Systemic Lupus Erythematosus in Chinese Han Population.

  8. a substitution mutation, R152C, impairs Pol beta polymerase activity and DNA base excision repair efficiency.

  9. Data show that esophageal carcinoma (EC) cells expressing the DNA polymerase beta K167I variant to be sensitive to DNA damaging agents.

  10. Pol lambda (zeige POLL Proteine) can incorporate rNMPs opposite normal bases or 8-oxo-G, and with a different fidelity. Further, the incorporation of rNMPs opposite 8-oxo-G delays repair by DNA glycosylases.

Mouse (Murine) Polymerase (DNA Directed), beta (POLB) Interaktionspartner

  1. pol beta plays an important role in bypassing a 5',8-cyclo-dA during DNA replication and repair.

  2. we show here that heterozygosity for a Y265C mutation in Polbeta, a key polymerase in the BER pathway, is enough to significantly reduce both the number of expansions seen in paternal gametes and the extent of somatic expansion in some tissues

  3. The aberrant DNA replication mediated by the PCNA (zeige PCNA Proteine)-DNA pol-b complex induces p53 (zeige TP53 Proteine)-dependent neuronal cell death

  4. Y265C POLB mutation leads to several pathologies associated with SLE and short CDR3 regions during VDJ recombination in B cells.

  5. Pol beta deficiency could enable ROS (zeige ROS1 Proteine) accumulation.

  6. Results show that deficiency of either DNA polymerases beta or lambda or both results in a modest but significant decrease in V region somatic hypermutation (SHM (zeige CNTNAP1 Proteine)) with no effect on mutation specificity, suggesting no direct role in SHM (zeige CNTNAP1 Proteine).

  7. Transient OGG1 (zeige OGG1 Proteine), APE1 (zeige APEX1 Proteine), PARP1 (zeige PARP1 Proteine) and Polbeta expression in an Alzheimer's disease mouse model.

  8. Data indicate an association of ovarian stimulation with a downregulation of mRNAs encoding the base excision repair proteins APEX1 (zeige APEX1 Proteine) and POLB as well as the 5-methyl-CpG-binding domain protein MBD3 (zeige MBD3 Proteine) in individual morula embryos.

  9. Overexpression of Pol beta could reduce oxidative damage and protect cells from hydroquinone genotoxicity.

  10. Polbeta could protect cells from apoptosis induced by hydroquinone through decrease of ROS (zeige ROS1 Proteine) level and depolarization of mitochondria.

POLB Protein Überblick

Protein Überblick

The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date.

Alternative names and synonyms associated with POLB

  • polymerase (DNA directed), beta (polb)
  • polymerase (DNA directed), beta (POLB)
  • DNA polymerase X family protein (polB)
  • DNA polymerase beta-like (LOC100526021)
  • polymerase (DNA directed), beta (Polb)
  • A430088C08Rik Protein
  • DDBDRAFT_0186152 Protein
  • DDBDRAFT_0215784 Protein
  • DDBDRAFT_0232376 Protein
  • DDB_0186152 Protein
  • DDB_0215784 Protein
  • DDB_0232376 Protein
  • POLB Protein
  • wu:fa97a05 Protein
  • zgc:109924 Protein

Bezeichner auf Proteinebene für POLB

DNA-directed DNA polymerase beta , DNA polymerase beta , polymerase (DNA directed), beta , DNA polymerase beta-like , DNA pol beta , DNA polymerase beta subunit , mutant DNA polymerase beta , Pol beta , polymerase-beta

GENE ID SPEZIES
448741 Xenopus (Silurana) tropicalis
554204 Danio rerio
704801 Macaca mulatta
737210 Pan troglodytes
8624738 Dictyostelium discoideum AX4
100348691 Oryctolagus cuniculus
100393825 Callithrix jacchus
100441812 Pongo abelii
100526021 Sus scrofa
5423 Homo sapiens
614688 Bos taurus
397973 Xenopus laevis
18970 Mus musculus
29240 Rattus norvegicus
426794 Gallus gallus
494001 Canis lupus familiaris
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