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reveal the Minichromosome Maintenance Complex to be a critical and directly regulated node within the miR (zeige MLXIP ELISA Kits)-183 signaling network in MYCN (zeige MYCN ELISA Kits)-amplified neuroblastoma (zeige ARHGEF16 ELISA Kits) cells. Randomly selected MCMs 3 and 5 were experimentally confirmed as direct targets of miR (zeige MLXIP ELISA Kits)-183.
The results of our preliminary study emphasize the need for future research on MCM-3 as a sensitive proliferation marker, providing an alternative to Ki-67 (zeige MKI67 ELISA Kits), in cases of various major salivary gland epithelial tumors in children and adolescents.
These data establish new functions for KEAP1 within the nucleus and identify MCM3 as a novel substrate of the KEAP1-CUL3-RBX1 E3 ligase.
The aim of this study is to analyze the immunoexpression of Ki67 (zeige MKI67 ELISA Kits), p53 (zeige TP53 ELISA Kits), MCM3 and PCNA (zeige PCNA ELISA Kits) markers in epithelial remnants of dental follicles of impacted teeth and to identify a possible correlation between the immunoexpression of these markers in dentigerous cysts and keratocystic odontogenic tumors.
High MCM-3 expression correlated with Cutaneous T-cell Lymphomas.
normal DNA replication and replication checkpoint activation is regulated through the novel phosphorylation of MCM3 by Chk1 (zeige CHEK1 ELISA Kits)
Results show that in Glioma patients, MCM 2 (zeige MCM2 ELISA Kits), MCM3 and MCM7 (zeige MCM7 ELISA Kits) mRNA are up-regulated and correlated with poor outcome.
Of the total, the deregulation of several genes (CDK1 (zeige CDK1 ELISA Kits), CDK2 (zeige CDK2 ELISA Kits), CDK4 (zeige CDK4 ELISA Kits), MCM2 (zeige MCM2 ELISA Kits), MCM3, MCM4 (zeige MCM4 ELISA Kits), EIF3a (zeige EIF6 ELISA Kits) and RPN2 (zeige PSMD1 ELISA Kits)) were potentially associated with disease development and progression.
Relatively lower MCM3 protein expression in follicular variant of papillary thyroid carcinoma comparing to classical type could be due to a different tumorigenic pathway favored in this type of tissue.
Expression of KB cell MCM3 was not affected by doxorubicin.
Mcm3-deficient erythroblasts display aberrant DNA replication patterns and fail to complete maturation, causing lethal anemia.
interaction with GANP (zeige MCM3AP ELISA Kits) DNA-primase is associated with a novel phosphatase component G5PR (zeige PPP2R3C ELISA Kits)
Depletion of Orc2 and Mcm3 by siRNA leads to an inhibition of cell proliferation, an altered cell cycle distribution as well as to multinucleated cells with insufficiently organised microtubules.
analysis of carboxyl-terminal MCM3 phosphorylation sites and their motifs
These data reveal that CDK (zeige CDK4 ELISA Kits)-dependent MCM3 phosphorylation contributes to the regulated formation of the MCM2-7 (zeige MCM2 ELISA Kits) complex.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene.
, minichromosome maintenance 3
, minichromosome maintenance-PCR2
, MCM3 minichromosome maintenance deficient 3
, zygotic minichromosome maintenance protein 3
, DNA replication licensing factor MCM3
, DNA polymerase alpha holoenzyme-associated protein P1
, DNA replication factor MCM3
, RLF subunit beta
, cervical cancer proto-oncogene 5
, hRlf beta subunit
, minichromosome maintenance deficient 3
, replication licensing factor, beta subunit
, P1 homolog
, XRLF subunit beta
, maternal DNA replication licensing factor mcm3
, maternal minichromosome maintenance protein 3
, mini chromosome maintenance deficient