anti-Ligase IV, DNA, ATP-Dependent (LIG4) Antikörper

anti-Ligase IV, DNA, ATP-Dependent Antikörper (LIG4)
Auf finden Sie aktuell 65 Ligase IV, DNA, ATP-Dependent (LIG4) Antikörper von 16 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Ligase IV, DNA, ATP-Dependent Proteine (3) und Ligase IV, DNA, ATP-Dependent Kits (1) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 76 Ligase IV, DNA, ATP-Dependent Produkte verfügbar.
5830471N16Rik, DNA LIGASE IV, DNL4, LIG4, lig4-A, tiny, zgc:165595

Meistgesuchte Reaktivitäten zu anti-Ligase IV, DNA, ATP-Dependent (LIG4) Antikörper

Wählen Sie die Spezies und Applikation aus

anti-Human Antikörper:

anti-Mouse (Murine) Antikörper:

anti-Rat (Rattus) Antikörper:

Alle verfügbaren anti-Ligase IV, DNA, ATP-Dependent Antikörper

Sie gelangen zu unserer vorgefilterten Suche.

Am meisten referenzierte anti-Ligase IV, DNA, ATP-Dependent Antikörper

  1. Human Polyclonal LIG4 Primary Antibody für IHC (p), IHC - ABIN189697 : Ducu, Dayaram, Marriott: The HTLV-1 Tax oncoprotein represses Ku80 gene expression. in Virology 2011 (PubMed)
    Zeige alle 2 Referenzen für 189697

  2. Cow (Bovine) Polyclonal LIG4 Primary Antibody für IHC, WB - ABIN2778272 : Smith, Riballo, Kysela, Baldeyron, Manolis, Masson, Lieber, Papadopoulo, Jeggo: Impact of DNA ligase IV on the fidelity of end joining in human cells. in Nucleic acids research 2003 (PubMed)

  3. Human Polyclonal LIG4 Primary Antibody für ICC, IF - ABIN4305497 : Sousa, Zub, Aas, Hanssen-Bauer, Demirovic, Sarno, Tian, Liabakk, Slupphaug: An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells. in PLoS ONE 2013 (PubMed)

  4. Human Polyclonal LIG4 Primary Antibody für IHC, ELISA - ABIN1450599 : Dunham, Matthews, Burton, Ashurst, Howe, Ashcroft, Beare, Burford, Hunt, Griffiths-Jones, Jones, Keenan, Oliver, Scott, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey et al.: The DNA sequence and analysis of human chromosome 13. ... in Nature 2004 (PubMed)

Weitere Antikörper gegen Ligase IV, DNA, ATP-Dependent Interaktionspartner

Arabidopsis thaliana Ligase IV, DNA, ATP-Dependent (LIG4) Interaktionspartner

  1. DNA ligase IV (LIG4) is not essential for telomere joining.

Human Ligase IV, DNA, ATP-Dependent (LIG4) Interaktionspartner

  1. found that the rs228593, rs2267437 and rs1805388 functional polymorphisms probably alter the level of expression of the ATM (zeige ATM Antikörper), XRCC6 (zeige XRCC6 Antikörper) and LIG4 genes, respectively, being important in the maintenance of genomic instability in MDS (zeige PAFAH1B1 Antikörper)

  2. marked overlap of dyskeratosis congenita with four other genetic syndromes, confounding accurate diagnosis and subsequent management. Patients with clinical features of dyskeratosis congenita need to have genetic analysis of USB1 (zeige USB1 Antikörper), LIG4 and GRHL2 (zeige GRHL2 Antikörper) in addition to the classical dyskeratosis congenita genes and telomere length measurements.

  3. The rs1805388 in LIG4 was associated with increased radioresistance.

  4. LIG4 is highly upregulated in human colorectal cancer cells.

  5. Five novel mutations in LIG4 and a potential hotspot mutation (c.833G > T; p.R278L) in the Chinese population with LIG4 deficiency syndrome were identified.

  6. Our study identifies LIG4 as a predictor of an increased risk for early biochemical recurrence in prostate cancer

  7. The genetic polymorphisms in LIG4 rs1805388 and HSPB1 (zeige HSPB1 Antikörper) rs2868371 were not obviously correlated with the risk of radiation pneumonitis and radiation-induced lung injury of lung cancer.

  8. our results suggest that LIG4 rs10131 polymorphism in the DNA repair pathways plays an important role in the risk of glioma in a Chinese population.

  9. Our data showed that Cd altered the phosphorylation of DNA-PKcs (zeige PRKDC Antikörper), and reduced the expression of both XRCC4 (zeige XRCC4 Antikörper) and Ligase IV in irradiated cells.

  10. despite several limitations, this meta-analysis suggested that LIG4 T9I genetic variant is associated with a decreased risk of cancer among Caucasians, however, the rs1805386 gene polymorphism is not a risk factor of cancer.

Mouse (Murine) Ligase IV, DNA, ATP-Dependent (LIG4) Interaktionspartner

  1. The data firmly demonstrate Lig4(R278H) activity renders nonhomologous end-joining (NHEJ) DNA repair to be more error-prone, and predict increased error-prone NHEJ and A-EJ suppression as the cause of defective B lymphopoiesis in Lig4 patients.

  2. To promote homology-directed r at the expense of nonhomologous end joining , we targeted DNA ligase IV, a key enzyme in the NHEJ pathway, using the inhibitor Scr7. This approach should be applicable to other customizable endonucleases

  3. Lig4 and XRCC1 (zeige XRCC1 Antikörper) double-deficient cells switch as efficiently as Lig4-deficient cells, clearly indicating that XRCC1 (zeige XRCC1 Antikörper) is dispensable for A-EJ in CH12F3 cells during class switch recombination

  4. These studies provide insight into the interplay between DNA damage responses in the developing brain and the DNA ligase IV plat (zeige PLAT Antikörper) the role in repairing endogenously arising DNA double-strand breaks.

  5. Lig4-deficient B cells have reduced, but still substantial, immunoglobulins class switch recombination

  6. Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID (zeige PRKDC Antikörper) and represents a model for human LIG4 syndrome.

  7. Lig4 and Rad54 (zeige RAD54L Antikörper) cooperate to support cellular proliferation, dna repair, and prevent chromosome and single chromatid aberrations

  8. LIG4 mutations can result in either a developmental defect with immunological abnormalities or a severe combined immunodeficiency (zeige PRKDC Antikörper) picture with normal development.

  9. DNA Ligase IV is engaged in extrachromosomal circular major satellite DNA synthesis

  10. DNA-PK kinase activity results in disassembly of the Ku/DNA ligase IV/Xrcc4 (zeige XRCC4 Antikörper) complex

Ligase IV, DNA, ATP-Dependent (LIG4) Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.

Alternative names and synonyms associated with Ligase IV, DNA, ATP-Dependent (LIG4)

  • ligase IV, DNA, ATP-dependent (lig4) Antikörper
  • ligase IV, DNA, ATP-dependent (LIG4) Antikörper
  • DNA ligase 4-like (LOC100212302) Antikörper
  • DNA ligase 4 (CpipJ_CPIJ005161) Antikörper
  • DNA ligase 4 (PTRG_09982) Antikörper
  • DNA ligase 4 (MCYG_05151) Antikörper
  • ligase IV, DNA, ATP-dependent (Lig4) Antikörper
  • ATP-dependent DNA ligase implicated in dsDNA break repair via nonhomologous end-joining (LIG4) Antikörper
  • DNA ligase 4 (ATLIG4) Antikörper
  • 5830471N16Rik Antikörper
  • DNA LIGASE IV Antikörper
  • DNL4 Antikörper
  • LIG4 Antikörper
  • lig4-A Antikörper
  • tiny Antikörper
  • zgc:165595 Antikörper

Bezeichner auf Proteinebene für LIG4

DNA ligase 4 , ligase IV, DNA, ATP-dependent , DNA ligase IV , DNA ligase (ATP) 4 , GLEAN_12219 , ligase4-like protein , DNA ligase 4-like , dsDNA break repair ligase , polydeoxyribonucleotide synthase [ATP] 4 , DNA joinase , DNA repair enzyme , polynucleotide ligase , sealase

569525 Danio rerio
781252 Bos taurus
100051479 Equus caballus
100212302 Hydra magnipapillata
6036973 Culex quinquefasciatus
6348281 Pyrenophora tritici-repentis Pt-1C-BFP
9230237 Arthroderma otae CBS 113480
452653 Pan troglodytes
549735 Xenopus (Silurana) tropicalis
657210 Tribolium castaneum
100476294 Ailuropoda melanoleuca
100600607 Nomascus leucogenys
3643043 Candida albicans SC5314
835822 Arabidopsis thaliana
394389 Xenopus laevis
418764 Gallus gallus
3981 Homo sapiens
485544 Canis lupus familiaris
319583 Mus musculus
290907 Rattus norvegicus
100173511 Pongo abelii
Ausgewählte Anbieter für anti-Ligase IV, DNA, ATP-Dependent (LIG4) Antikörper
Haben Sie etwas anderes gesucht?