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ERCC1 Proteine (ERCC1)

Excision Repair Cross Complementing Polypeptide-1 Proteine (ERCC1)
Auf finden Sie aktuell 11 Excision Repair Cross Complementing Polypeptide-1 (ERCC1) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen ERCC1 Antikörper (249) und ERCC1 Kits (20) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 290 ERCC1 Produkte verfügbar.
COFS4, Ercc-1, RAD10, T12H1.18, T12H1_18, UV20, UVR7, UV REPAIR DEFICIENT 7
alle Proteine anzeigen Gen GeneID UniProt
Ratte ERCC1 ERCC1 292673  
ERCC1 13870 P07903
ERCC1 2067 P07992

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Am meisten referenzierte ERCC1 Proteine

  1. Human ERCC1 Protein expressed in Escherichia coli (E. coli) - ABIN1098618 : van Duin, de Wit, Odijk, Westerveld, Yasui, Koken, Hoeijmakers, Bootsma: Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10. in Cell 1986 (PubMed)
    Zeige alle 2 Referenzen für ABIN1098618

Weitere Proteine zu ERCC1 Interaktionspartnern

Arabidopsis thaliana Excision Repair Cross Complementing Polypeptide-1 (ERCC1) Interaktionspartner

  1. ERCC1 and XPF protect short telomeres from homologous recombination.

Mouse (Murine) Excision Repair Cross Complementing Polypeptide-1 (ERCC1) Interaktionspartner

  1. we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b (zeige BUB1B Proteine)(H/H) mice, which have a faulty mitotic checkpoint (zeige BUB3 Proteine), and Ercc1(-/Delta7) mice, defective in nucleotide excision repair and inter-strand crosslink repair. we found that Bub1b (zeige BUB1B Proteine)(H/H), but not Ercc1(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t...

  2. these results establish USP45 as a new regulator of XPF-ERCC1 crucial for efficient DNA repair

  3. ERCC1 is critical for protecting chondrocytes from catabolic stress and is associated with the pathophysiology of osteoarthritis.

  4. SLX4 is a tumor suppressor, which activates XPF-ERCC1 nuclease (zeige DCLRE1C Proteine) specificity in DNA crosslink repair.

  5. ERCC1 is essential for melanoma growth and resistance to cisplatin.

  6. Smad4 (zeige SMAD4 Proteine) loss-associated Snail (zeige SNAI1 Proteine) reduction compromises Ercc1-mediated DNA repair, contributing to increased UV-induced skin carcinogenesis.

  7. analysis of accelerated loss of hearing and vision in the DNA-repair deficient Ercc1(delta/-) mouse

  8. This study demonistrated that the ERCC1 deficiency-associated downregulation of the cholesterol biosynthesis pathway is at least in part due to lowered expression of its master transcription factor SREBF2 (zeige SREBF2 Proteine)

  9. we have identified a novel skin-specific Ercc1 transcript in mice that originates from a promoter approximately 400 bp upstream of the normal promoter, rather than from more distant potential transcriptional start sites.

  10. Ercc1(Delta/-) mice develop widespread astrocytosis and microgliosis, and motor neuron loss and denervation of skeletal muscle fibers.

Human Excision Repair Cross Complementing Polypeptide-1 (ERCC1) Interaktionspartner

  1. Based on structural models, NMR titrations, DNA-binding studies, site-directed mutagenesis, charge distribution, and sequence conservation, we propose that the HhH domain of ERCC1 binds to dsDNA upstream of the damage, and XPF binds to the non-damaged strand within a repair bubble

  2. Meta-analysis indicated that the ERCC1 rs3212986 polymorphism and 2 polymorphisms in ERCC2 (zeige ERCC2 Proteine) gene (rs13181 and rs1799793) contributed to the susceptibility of glioma.

  3. ERCC1-SNP in combination with mRNA ERCC1, DPYD (zeige DPYD Proteine), and ERBB2 (zeige ERBB2 Proteine) from pretherapeutic endoscopic biopsies can predict minor response to chemoradiation, as a basis for individualized therapy of advanced esophageal cancer.

  4. Reduced excision repair cross-complementation group 1 (ERCC1) and group 2 (ERCC2 (zeige ERCC2 Proteine)) RNA expressions were detected in 50 (78.1%) and 48 (75%) cases, respectively whereas reduced proteins were detected in 48 cases (75%) for ERCC1 and ERCC2 (zeige ERCC2 Proteine).

  5. ERCC1 expression was identified as a prognostic marker for overall survival in the patient cohort with operable lesions. Taken together, our data identify ERCC1 as a disease marker in lung adenoma patients from Xuanwei and confirm the significance of resection for the subsequent effect of platinum treatment in these patients

  6. ERCC1 is expressed in a significant proportion of upper tract urothelial carcinoma and is linked with tumor necrosis, but its expression appears not to be associated with prognosis following radical nephroureterectomy.

  7. RRM1 (zeige RRM1 Proteine) and ERCC1 expression levels did not show any relationship with overall survival.

  8. ERCC1 and BRCA1 were overexpressed in A549/DDP (zeige TIMM8A Proteine) compared with A549 (P<0.05). ERCC1 and BRCA1siRNA transfection can significantly reduce ERCC1 and BRCA1 mRNA and protein expression (P<0.05). Downregulating ERCC1 and BRCA1 expression obviously inhibited cell proliferation and increased caspase 3 (zeige CASP3 Proteine) activity (P<0.05). Downregulating ERCC1 and BRCA1 significantly decreased PI3K (zeige PIK3CA Proteine) and AKT (zeige AKT1 Proteine) phosphorylation levels (P<0.05).

  9. RRM1 (zeige RRM1 Proteine) and ERCC wild type alleles are risk-reducing factor for Coronary artery disease (CAD). Also, carrying RRM1 (zeige RRM1 Proteine) A allele might have a protective effect for smokers.

  10. The genetic polymorphisms of ERCC1-8092 are associated with the risk of hepatocellular carcinoma in Guangxi Zhuang population of China

ERCC1 Protein Überblick

Protein Überblick

The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.

Alternative names and synonyms associated with ERCC1

  • DNA excision repair protein ERCC-1 (ERCC1)
  • excision repair cross-complementing rodent repair deficiency, complementation group 1 (Ercc1)
  • excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) (ERCC1)
  • COFS4 Protein
  • Ercc-1 Protein
  • RAD10 Protein
  • T12H1.18 Protein
  • T12H1_18 Protein
  • UV20 Protein
  • UVR7 Protein

Bezeichner auf Proteinebene für ERCC1

DNA excision repair protein ERCC-1 , excision repair cross-complementing 1 , excision repair 1

819685 Arabidopsis thaliana
292673 Rattus norvegicus
13870 Mus musculus
2067 Homo sapiens
612282 Canis lupus familiaris
100286808 Sus scrofa
615637 Bos taurus
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