ERCC1 Proteine (ERCC1)

Excision Repair Cross Complementing Polypeptide-1 Proteine (ERCC1)
Auf finden Sie aktuell 11 Excision Repair Cross Complementing Polypeptide-1 (ERCC1) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen ERCC1 Antikörper (260) und ERCC1 Kits (22) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 304 ERCC1 Produkte verfügbar.
COFS4, Ercc-1, ercc1, RAD10, T12H1.18, T12H1_18, UV20, UVR7, UV REPAIR DEFICIENT 7
alle Proteine anzeigen Gen GeneID UniProt
ERCC1 2067 P07992
ERCC1 13870 P07903
Ratte ERCC1 ERCC1 292673  

Weitere Synonyme anzeigen

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Am meisten referenzierte ERCC1 Proteine

  1. Human ERCC1 Protein expressed in Escherichia coli (E. coli) - ABIN1098618 : van Duin, de Wit, Odijk, Westerveld, Yasui, Koken, Hoeijmakers, Bootsma: Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10. in Cell 1986 (PubMed)
    Zeige alle 2 Referenzen für 1098618

Weitere Proteine zu ERCC1 Interaktionspartnern

Arabidopsis thaliana Excision Repair Cross Complementing Polypeptide-1 (ERCC1) Interaktionspartner

  1. ERCC1 and XPF protect short telomeres from homologous recombination.

Mouse (Murine) Excision Repair Cross Complementing Polypeptide-1 (ERCC1) Interaktionspartner

  1. Dietary tryptophan restriction increased microbial diversity and made the gut (zeige GUSB Proteine) microbiota composition of old Ercc1(-/Delta7) mice more similar to that of young WT mice.

  2. ERCC1-XPF cooperates with CTCF (zeige CTCF Proteine) and cohesin to facilitate the developmental silencing of imprinted genes and that persistent DNA damage triggers chromatin changes that affect gene expression programs associated with NER (zeige NR1H2 Proteine) disorders.

  3. we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b (zeige BUB1B Proteine)(H/H) mice, which have a faulty mitotic checkpoint (zeige BUB3 Proteine), and Ercc1(-/Delta7) mice, defective in nucleotide excision repair and inter-strand crosslink repair. we found that Bub1b (zeige BUB1B Proteine)(H/H), but not Ercc1(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t...

  4. these results establish USP45 as a new regulator of XPF-ERCC1 crucial for efficient DNA repair

  5. ERCC1 is critical for protecting chondrocytes from catabolic stress and is associated with the pathophysiology of osteoarthritis.

  6. SLX4 is a tumor suppressor, which activates XPF-ERCC1 nuclease (zeige DCLRE1C Proteine) specificity in DNA crosslink repair.

  7. ERCC1 is essential for melanoma growth and resistance to cisplatin.

  8. Smad4 (zeige SMAD4 Proteine) loss-associated Snail (zeige SNAI1 Proteine) reduction compromises Ercc1-mediated DNA repair, contributing to increased UV-induced skin carcinogenesis.

  9. analysis of accelerated loss of hearing and vision in the DNA-repair deficient Ercc1(delta/-) mouse

  10. This study demonistrated that the ERCC1 deficiency-associated downregulation of the cholesterol biosynthesis pathway is at least in part due to lowered expression of its master transcription factor SREBF2 (zeige SREBF2 Proteine)

Human Excision Repair Cross Complementing Polypeptide-1 (ERCC1) Interaktionspartner

  1. Genetic polymorphism in ERCC1 gene is associated with response to chemotherapy in osteosarcoma.

  2. ERCC1 was not detectable in the nucleus of the XPF knockout cells indicating the necessity of a functional XPF/ERCC1 heterodimer to allow ERCC1 to enter the nucleus.

  3. There is no association between the ERCC1 C19007T polymorphism and platinum-based chemotherapy effectiveness in ovarian cancer. The polymorphism did not have a significant impact on platinum-based chemotherapy in non-responders and responders.

  4. The T allele at ERCC1 rs11615 may interact with smoking and alcohol drinking status to determine personal susceptibility to colorectal cancer.

  5. Strikingly, the addition of the single-stranded DNA (ssDNA)-binding replication protein A (RPA) selectively restores XPF-ERCC1 endonuclease activity on this structure. The 5'-3' exonuclease SNM1A can load from the XPF-ERCC1-RPA-induced incisions and digest past the crosslink to quantitatively complete the unhooking reaction.

  6. ERCC1 mutation along with BRCA1 mutation confers chemoresistance in breast cancer.

  7. The authors have discovered a major sub-pathway of conventional long-patch base excision repair that involves formation of a 9-nucleotide gap 5' to the lesion. This new sub-pathway is mediated by RECQ1 (zeige RECQL Proteine) DNA helicase and ERCC1-XPF endonuclease in cooperation with PARP1 poly(ADP-ribose) polymerase (zeige PARP1 Proteine) and RPA (zeige RPA1 Proteine).

  8. Based on structural models, NMR titrations, DNA-binding studies, site-directed mutagenesis, charge distribution, and sequence conservation, we propose that the HhH domain of ERCC1 binds to dsDNA upstream of the damage, and XPF binds to the non-damaged strand within a repair bubble

  9. Meta-analysis indicated that the ERCC1 rs3212986 polymorphism and 2 polymorphisms in ERCC2 (zeige ERCC2 Proteine) gene (rs13181 and rs1799793) contributed to the susceptibility of glioma.

  10. ERCC1-SNP in combination with mRNA ERCC1, DPYD (zeige DPYD Proteine), and ERBB2 (zeige ERBB2 Proteine) from pretherapeutic endoscopic biopsies can predict minor response to chemoradiation, as a basis for individualized therapy of advanced esophageal cancer.

ERCC1 Protein Überblick

Protein Überblick

The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.

Alternative names and synonyms associated with ERCC1

  • excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) (ERCC1)
  • excision repair cross-complementing rodent repair deficiency, complementation group 1 (Ercc1)
  • DNA excision repair protein ERCC-1 (CC1G_04546)
  • DNA excision repair protein ERCC-1 (CpipJ_CPIJ013903)
  • DNA excision repair protein ERCC-1 (PITG_13719)
  • DNA excision repair protein ERCC-1 (ercc1)
  • DNA excision repair protein ERCC-1 (ERCC1)
  • excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) (ercc1)
  • COFS4 Protein
  • Ercc-1 Protein
  • ercc1 Protein
  • RAD10 Protein
  • T12H1.18 Protein
  • T12H1_18 Protein
  • UV20 Protein
  • UVR7 Protein

Bezeichner auf Proteinebene für ERCC1

DNA excision repair protein ERCC-1 , excision repair 1 , excision repair cross-complementing 1 , excision repair protein , excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)

2067 Homo sapiens
13870 Mus musculus
292673 Rattus norvegicus
450179 Pan troglodytes
615637 Bos taurus
6006551 Coprinopsis cinerea okayama7130
6048458 Culex quinquefasciatus
9461287 Phytophthora infestans T30-4
100286713 Salmo salar
819685 Arabidopsis thaliana
380190 Xenopus laevis
574267 Macaca mulatta
612282 Canis lupus familiaris
100135224 Xenopus (Silurana) tropicalis
100286808 Sus scrofa
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