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anti-BRCA2 (BRCA2) Antikörper

Bezeichnung:
anti-Breast Cancer 2, Early Onset Antikörper (BRCA2)
Auf www.antikoerper-online.de finden Sie aktuell 90 Breast Cancer 2, Early Onset (BRCA2) Antikörper von 23 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen BRCA2 Kits (25) und BRCA2 Proteine (2) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 120 BRCA2 Produkte verfügbar.
Synonyme:
AI256696, AW045498, BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1, GLM3, PNCA2, RAB163
Alle Antikörper anzeigen Gen GeneID UniProt
BRCA2 12190 P97929
BRCA2 675 P51587
BRCA2 360254  

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Meistgesuchte Reaktivitäten zu anti-BRCA2 (BRCA2) Antikörper

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anti-Mouse (Murine) BRCA2 Antikörper:

anti-Human BRCA2 Antikörper:

anti-Rat (Rattus) BRCA2 Antikörper:

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Am meisten referenzierte anti-BRCA2 Antikörper

  1. Human Monoclonal BRCA2 Primary Antibody für IHC, IHC (p) - ABIN445491 : Wu, Jiang, Thangaraju, Wu, Couch: Induction of the BRCA2 promoter by nuclear factor-kappa B. in The Journal of biological chemistry 2000 (PubMed)
    Zeige alle 2 Referenzen für ABIN445491

  2. Human Monoclonal BRCA2 Primary Antibody für IHC, IHC (fro) - ABIN445493 : Bernard-Gallon, Déchelotte, Vissac, Aunoble, Cravello, Malpuech, Bignon: BRCA1 and BRCA2 protein expressions in an ovotestis of a 46, XX true hermaphrodite. in Breast cancer research : BCR 2001 (PubMed)
    Zeige alle 2 Referenzen für ABIN445493

  3. Human Polyclonal BRCA2 Primary Antibody für IHC, ELISA - ABIN1533759 : Wooster, Bignell, Lancaster, Swift, Seal, Mangion, Collins, Gregory, Gumbs, Micklem: Identification of the breast cancer susceptibility gene BRCA2. in Nature 1996 (PubMed)
    Zeige alle 2 Referenzen für ABIN1533759

  4. Human Polyclonal BRCA2 Primary Antibody für IHC, IHC (fro) - ABIN4285196 : Moeller, Yordy, Williams, Giri, Raju, Molkentine, Byers, Heymach, Story, Lee, Sturgis, Weber, Garden, Ang, Schwartz: DNA repair biomarker profiling of head and neck cancer: Ku80 expression predicts locoregional failure and death following radiotherapy. in Clinical cancer research : an official journal of the American Association for Cancer Research 2011 (PubMed)

Weitere Antikörper gegen BRCA2 Interaktionspartner

Zebrafish Breast Cancer 2, Early Onset (BRCA2) Interaktionspartner

  1. Carcinogenesis in zebrafish with combined mutations in tp53 (zeige TP53 Antikörper) and brca2 typically requires biallelic mutation or loss of at least one of these genes.

  2. The novel role of Brca2 in organizing the vertebrate egg nucleus may provide new insights into the origin of ovarian cancer

  3. critical roles for brca2 in ovarian development and tumorigenesis in reproductive tissues

Mouse (Murine) Breast Cancer 2, Early Onset (BRCA2) Interaktionspartner

  1. Merit40 (zeige BABAM1 Antikörper) mutation exacerbated ICL-induced chromosome instability in the context of concomitant Brca2 deficiency but not in conjunction with Fancd2 (zeige FANCD2 Antikörper) mutation.

  2. Heterozygous and homozygous Brca2 mutation may lead to dysfunction in T cell populations.

  3. BRCA2 exon 27 domain maintains chromosomal integrity at both stalled and collapsed replication forks consistent with involvement in both replication fork maintenance and double strand break repair.

  4. we use a genetically engineered mouse model of BRCA2-associated hereditary breast cancer to study drug resistance to several types of chemotherapy and PARP (zeige PARP1 Antikörper) inhibition.

  5. BRCA2-mediated sequestration of nuclear RAD51 (zeige RAD51 Antikörper) serves to prevent inappropriate DNA interactions.

  6. BRCA2 directly represses the expression of IFN-related genes

  7. the models reveal novel aspects of cancer evolution in carriers of germline BRCA2 mutations, provide new insights into the tumour suppressive role of BRCA2

  8. genetic stability, and hematopoietic differentiation potential of gene-corrected Brca2(Delta) (27/) (Delta) (27) iPSCs, achievements and limitations in the application of current reprogramming approaches in hematopoietic stem cell therapy are also discussed.

  9. Results suggest that cellular levels of Brca2 and Rad51 (zeige RAD51 Antikörper) are mutually dependent on each other, and that low levels of these proteins provide selective pressure for reduction of p53 (zeige TP53 Antikörper), which permits cell growth

  10. BRCA2 accumulates DNA damage, which triggers checkpoint signalling and ARF (zeige CDKN2A Antikörper) activation

Human Breast Cancer 2, Early Onset (BRCA2) Interaktionspartner

  1. Data suggest that, similar to Caucasians, a significant proportion of Asian ovarian cancer was attributed to germline mutations in BRCA1 and to a lesser extent in BRCA2.

  2. We found an approximately approximately 3 fold increased rate of high RS among BRCA1 and 2 carriers with ER positive breast cancer (BC)compared with the general BC population.

  3. results suggests that BRCA1 mutation carriers with breast cancer are more likely to have P53 (zeige TP53 Antikörper) overexpression compared with BRCA2 mutation carriers and non-carriers (Meta-analysis).

  4. We recommend BRCA1/2 genetic testing to all Chinese women diagnosed with EOC to identify HBOC families, to provide genetic counseling and clinical management for at-risk relatives. Mutation carriers may also benefit from PARP (zeige COL11A2 Antikörper)-targeted therapies.

  5. BRCA2 mutation is associated with breast cancer.

  6. Five patients were identified with intragenic mutations predicted to restore BRCA1/2 open reading frames, including two patients with multiple independent reversion alleles.

  7. the primary goal of this study was to use multiplex PCR with morphological and immunohistochemical methods for the detection of BRCA mutation(BRCA1 or BRCA2), mtDNA 4977 deletion, and HPV genotyping in familial and nonfamilial breast cancers

  8. BRCA2-truncated protein resulted from the frame shift mutation was found to lose two putative nuclear localization signals and a Rad51 (zeige RAD51 Antikörper)-binding motif in the extreme C-terminal region by bioinformatic prediction

  9. soluble alpha-fetoprotein (zeige AFP Antikörper) is a marker for Fanconi anemia (zeige PALB2 Antikörper); FANC proteins form multi-protein complexes with BRCA proteins and are involved in homologous DNA repair [review]

  10. These results suggested that LIMD1 (zeige LIMD1 Antikörper) is a novel BRCA2-interacting protein and is involved in the centrosome localization of BRCA2 and suppression of LIMD1 (zeige LIMD1 Antikörper), causing abnormal cell division in EC cells.

BRCA2 Antigen-Profil

Beschreibung des Gens

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

Alternative names and synonyms associated with BRCA2

  • breast cancer 2, early onset (BRCA2) Antikörper
  • breast cancer 2, early onset (brca2) Antikörper
  • breast cancer 2 (Brca2) Antikörper
  • breast cancer 2, early onset (Brca2) Antikörper
  • AI256696 Antikörper
  • AW045498 Antikörper
  • BRCA2 Antikörper
  • BRCC2 Antikörper
  • BROVCA2 Antikörper
  • FACD Antikörper
  • FAD Antikörper
  • FAD1 Antikörper
  • FANCB Antikörper
  • FANCD Antikörper
  • FANCD1 Antikörper
  • GLM3 Antikörper
  • PNCA2 Antikörper
  • RAB163 Antikörper

Bezeichner auf Proteinebene für BRCA2

breast and ovarian cancer susceptibility protein 2 , breast cancer 2, early onset , breast cancer type 2 susceptibility protein-like , breast cancer type 2 susceptibility protein homolog , fanconi anemia group D1 protein homolog , BRCA1/BRCA2-containing complex, subunit 2 , breast and ovarian cancer susceptibility gene, early onset , breast cancer 2 tumor suppressor , breast cancer type 2 susceptibility protein , fanconi anemia group D1 protein , truncated breast and ovarian cancer susceptibility protein 2 , breast cancer 2, mutation 1, University of Wisconsin-Madison , breast cancer susceptibility protein 2

GENE ID SPEZIES
100064578 Equus caballus
566758 Danio rerio
584780 Strongylocentrotus purpuratus
721981 Macaca mulatta
100397509 Callithrix jacchus
452526 Pan troglodytes
100038818 Xenopus (Silurana) tropicalis
100601625 Nomascus leucogenys
12190 Mus musculus
675 Homo sapiens
360254 Rattus norvegicus
374139 Gallus gallus
474180 Canis lupus familiaris
507069 Bos taurus
493878 Felis catus
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