BRCA1 Proteine (BRCA1)

Bezeichnung:
Breast Cancer 1 Proteine (BRCA1)
Auf www.antikoerper-online.de finden Sie aktuell 10 Breast Cancer 1 (BRCA1) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen BRCA1 Antikörper (569) und BRCA1 Kits (30) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 624 BRCA1 Produkte verfügbar.
Synonyme:
BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53
alle Proteine anzeigen Gen GeneID UniProt
BRCA1 12189 P48754
BRCA1 672 P38398
BRCA1 497672 O54952

Weitere Synonyme anzeigen

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Weitere Proteine zu BRCA1 Interaktionspartnern

Mouse (Murine) Breast Cancer 1 (BRCA1) Interaktionspartner

  1. the aberrant proliferative capacity of Brca1(-/-) luminal progenitor cells is linked to the replication-associated DNA damage response, where proliferation of mammary progenitors is perpetuated by damage-induced, autologous NF-kappaB (zeige NFKB1 Proteine) signaling.

  2. We report here elevated recombination rates at telomeres in cells from human BRCA1 mutation carriers and in mouse embryonic stem cells lacking both copies of functional Brca1.

  3. loss of Brca1, a tumor suppressor that functions in DNA damage repair, in the mammary epithelium induced senescence with induction of p16 and a decline of stem cell function, which was rescued by p16 loss.

  4. Brca1-Wwox (zeige WWOX Proteine) interaction supports non-homologous end-joining as the dominant DSB repair pathway in Wwox (zeige WWOX Proteine)-sufficient cells

  5. Structure-guided separation-of-function mutations show that the RNF8 E2 stimulating activity is essential for DSB signaling in mammalian cells and is necessary for downstream recruitment of 53BP1 and BRCA1.

  6. Results reveal a broader biological role for BRCA1 in protecting the developing embryo from oxidative stress, and corroborate a role for DNA damage in the mechanism of ethanol embryotoxicity.

  7. This study uncovers a previously unappreciated, DNA repair-independent function of BRCA1 in antagonizing COBRA1 (zeige COBRA1 Proteine)-dependent transcription program during mammary gland development.

  8. loss of Brca1 in murine BM causes hematopoietic defects similar to those seen in people with FA, which provides strong evidence that Brca1 is critical for normal hematopoiesis and that Brca1 is a bona fide FA-like gene.

  9. The Brca1 pathway is dysregulated in spinal cord microglia from hSOD1G93A mice. Brca1 was upregulated at 90 days of age when microgliosis became evident.

  10. Brca1(GC-/-) models reveal that specific intra-follicular Brca1 loss alone, or combined with cancer-promoting genetic (Trp53 (zeige TP53 Proteine) loss) and endocrine (high serum follicle-stimulating hormone) changes, was not sufficient to cause ovarian tumors.

Human Breast Cancer 1 (BRCA1) Interaktionspartner

  1. Even if a BRCA1 mutation is already identified within a family, the presence of early onset breast cancer affected non-carriers hampers accurate risk estimates for both mutation carriers and other negative family members.

  2. polygenic risk scores may provide informative cancer risk stratification for male carriers of BRCA1/2 mutations that might enable these men and their physicians to make informed decisions on the type and timing of breast and prostate cancer risk management.

  3. Ras-induced senescent cells are hindered in their ability to recruit BRCA1 and 53BP1 (zeige TP53BP1 Proteine) to DNA damage sites. Whereas BRCA1 is downregulated at transcripts levels, 53BP1 (zeige TP53BP1 Proteine) loss is caused by activation of cathepsin L (zeige CTSL1 Proteine)-mediated degradation of 53BP1 (zeige TP53BP1 Proteine) protein. we discovered a marked downregulation of vitamin D receptor (VDR) during OIS, and a role for the vitamin D/VDR (zeige CYP27B1 Proteine) axis regulating the levels of these DNA repair

  4. CEP72 represents a putative oncogene in colorectal cancer that might negatively regulate the mitotic function of BRCA1 to ensure chromosomal stability

  5. NPM1 (zeige NPM1 Proteine) downregulation by P-STAT5 (zeige STAT5A Proteine) is mediated by impairing the BRCA1-BARD1 (zeige BARD1 Proteine) ubiquitin ligase, which controls the stability of NPM1 (zeige NPM1 Proteine). In turn, decreased NPM1 (zeige NPM1 Proteine) levels led to suppression of p53 (zeige TP53 Proteine) expression, resulting in enhanced cell survival.

  6. A breakdown in a BRCA/FANCD2/BRG1 (zeige SMARCA4 Proteine)/SNF (zeige SNRPA Proteine)-DeltaNP63-mediated DNA repair and differentiation maintenance process in mammary epithelial cells may contribute to sporadic breast cancer development.

  7. Neoadjuvant chemotherapy for BRCA1-associated ovarian carcinoma is accompanied by a rapid expansion of pre-existing BRCA1-proficient tumor clones suggesting that continuation of the same therapy after NACT and surgery may not be justified.

  8. Being a male BRCA1 or a BRCA2 (zeige BRCA2 Proteine) mutation carrier or even being clinically defined as having high cancer risk with no known BRCA mutation in men is not associated with any clinically significant risk for developing this rare entity.

  9. Data from our systematic review and meta-analysis suggests a causal relationship between germline BRCA1/2-pathogenic mutations and the development of Uterine serous carcinoma.

  10. study demonstrates that the individual and combined expression patterns of the DDR (zeige DDR1 Proteine) molecules PARP1 (zeige PARP1 Proteine), gammaH2AX (zeige H2AFX Proteine), BRCA1, and BRCA2 (zeige BRCA2 Proteine) could be predictive of the prognosis of STS (zeige STS Proteine) patients and suggests that controlling the activity of these DDR (zeige DDR1 Proteine) molecules could be employed in new therapeutic stratagems for the treatment of STS (zeige STS Proteine)

Cow (Bovine) Breast Cancer 1 (BRCA1) Interaktionspartner

  1. Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle.

  2. The gene-specific SNP marker analysis showed a significant association of BRCA1 C28300A with milk somatic cell scores.

  3. In general, OC use, childbearing and breastfeeding do not differ between BRCA1/2 carriers and non-carriers with ovarian cancer. However, the effects of tubal ligation may differ between BRCA1 carriers and non-carriers.

  4. Bovine BRCA1 was phosphorylated and nuclear speckling was enhanced in response to DNA-damaging agents.These results provide evidence that phosphorylation and nuclear relocalization are highly conserved features of the BRCA1 response to genotoxic stress.

Pig (Porcine) Breast Cancer 1 (BRCA1) Interaktionspartner

  1. Consensus-based recombinant adeno-associated virus-BRCA1 knock out virus vectors failed to induce BRCA1 knockout in Gottingen fibroblasts.

BRCA1 Protein Überblick

Protein Überblick

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

Alternative names and synonyms associated with BRCA1

  • breast cancer 1 (Brca1)
  • breast cancer 1, early onset (BRCA1)
  • breast cancer 1, early onset (Brca1)
  • BRCAI Protein
  • BRCC1 Protein
  • BROVCA1 Protein
  • IRIS Protein
  • PNCA4 Protein
  • PPP1R53 Protein
  • PSCP Protein
  • RNF53 Protein

Bezeichner auf Proteinebene für Breast Cancer 1 Proteine (BRCA1)

breast cancer associated 1 , breast cancer type 1 susceptibility protein homolog , BRCA1/BRCA2-containing complex, subunit 1 , RING finger protein 53 , breast and ovarian cancer susceptibility protein 1 , breast and ovarian cancer sususceptibility protein 1 , breast cancer type 1 susceptibility protein , protein phosphatase 1, regulatory subunit 53 , BRCA1 homologue , BRCA1 homolog

GENE ID SPEZIES
12189 Mus musculus
672 Homo sapiens
497672 Rattus norvegicus
353120 Bos taurus
403437 Canis lupus familiaris
100049662 Sus scrofa
449497 Pan troglodytes
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