Multiple Endocrine Neoplasia 1 ELISA Kits (MEN1)
Auf finden Sie aktuell 1 Multiple Endocrine Neoplasia 1 (MEN1) ELISA Kits von 1 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MEN1 Antikörper (125) und MEN1 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 133 MEN1 Produkte verfügbar.
AW045611, meai, menin, scg2
list all ELISA KIts Gen GeneID UniProt
MEN1 4221 O00255
Maus MEN1 MEN1 17283 O88559
Ratte MEN1 MEN1 29417 Q9WVR8

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MEN1 (MEN1) ELISA Kits nach Reaktivitäten

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Human Multiple Endocrine Neoplasia 1 (MEN1) Interaktionspartner

  1. The results provide novel molecular insights into the tumor suppressor activity of menin, which is partly mediated by proteasomal degradation of beta-catenin (zeige CTNNB1 ELISA Kits) and inhibition of Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling.

  2. knockdown of RPA2 (zeige RPA2 ELISA Kits) promoted formation of the menin-p65 (zeige GORASP1 ELISA Kits) complex and repressed the expression of NF-kappaB (zeige NFKB1 ELISA Kits)-mediated genes. RPA2 (zeige RPA2 ELISA Kits) expression was induced via an E2F1 (zeige E2F1 ELISA Kits)-dependent mechanism in MCF7 and MDA-MB-231 cells treated with NF-kappaB (zeige NFKB1 ELISA Kits) activators, TNF-alpha (zeige TNF ELISA Kits) or lipopolysaccharide (LPS (zeige IRF6 ELISA Kits)).

  3. Loss of Menin is an early event in pancreatic neuroendocrine tumorigenesis and that ATRX (zeige ATRX ELISA Kits)/DAXX (zeige DAXX ELISA Kits) loss and alternative lengthening of telomeres are relatively late events.

  4. The lack of somatic CDKN1B (zeige CDKN1B ELISA Kits) mutations in our samples points to a rare involvement in parathyroid adenomas, despite the frequent loss of nuclear p27 (zeige PAK2 ELISA Kits) expression. MEN1 biallelic inactivation seems to be directly related to down-regulation of p27 (zeige PAK2 ELISA Kits) expression through the inhibition of CDKN1B (zeige CDKN1B ELISA Kits) gene transcription.

  5. This result shows a novel mechanism whereby menin, a RNA-binding protein, facilitates the processing of its specific miRNA by regulating the dynamics of the menin-miR-24 Gene Regulatory Network at the level of pri-miRNA processing.

  6. findings reveal a previously unappreciated cross-talk between two crucial tumor suppressor genes, MEN1 and DAXX (zeige DAXX ELISA Kits), thought to work by independent pathways

  7. Multiple endocrine neoplasia type 1-related primary hyperparathyroidism patients experienced more common kidney complications but less skeletal issues, and a milder biochemical manifestation compared with SHPT patients. MEN1 mutation detection rate was 79.4% and 9 of the identified mutations were novel.

  8. miR-24-dependent expression of menin may be important in the regulation of nonmalignant and cholangiocarcinoma proliferation.

  9. rs2959656, a nonsynonymous variant in MEN1, is associated with the development of clinically active pituitary adenoma.

  10. Study acts as a further supplement of the genetic features of neuroendocrine tumors. Somatic mutations of three potential tumor-related genes (HRAS, PAK1 and MEN1) might contribute to the tumorigenesis of thymic neuroendocrine tumors with EAS.

Mouse (Murine) Multiple Endocrine Neoplasia 1 (MEN1) Interaktionspartner

  1. Menin and PRMT5 (zeige PRMT5 ELISA Kits) suppress GLP1R (zeige GLP1R ELISA Kits) transcript levels and PKA-mediated phosphorylation of FOXO1 (zeige FOXO1 ELISA Kits) and CREB (zeige CREB1 ELISA Kits).

  2. Inactivation of Kmt2a in Men1-deficient mice accelerated pancreatic islet tumorigenesis and shortened the average life span. Increases in cell proliferation were observed in mouse pancreatic islet tumors upon inactivation of both Kmt2a and Men1.

  3. Data suggest that menin inhibits differentiation into terminal effectors and positively controls proliferation and survival of Ag-specific CD8 (zeige CD8A ELISA Kits)(+) T cells that are activated upon infection; study uncovered an important role for menin in the immune response of CD8 (zeige CD8A ELISA Kits)(+) T cells to infection

  4. Our data further confirms that deletion of Men1 alone does not favour carcinoid development, but rather cooperates with additional loci.

  5. Menin binds on the promoter of Inhbb (zeige INHBB ELISA Kits) gene where it favours the recruitment of Ezh2 (zeige EZH2 ELISA Kits) via an indirect mechanism involving Akt (zeige AKT1 ELISA Kits)-phosphorylation.

  6. Results indicate that fasted male Men1(+/-) mice, in the early stage of development of MEN1, display glucose metabolic disorders. These disorders are caused not by direct induction of insulin (zeige INS ELISA Kits) resistance, but via increased glucagon (zeige GCG ELISA Kits) secretion and the consequent stimulation of hepatic glucose production.

  7. The inactivation of menin in the thyroid gland of young mice does not seem to change the histological pattern, but it influences the proliferation of follicular cells. Further molecular studies especially in aged mice are needed to better understand the correlation between certain oncogenes and the inactive status of menin.

  8. Data show that progranulin is upregulated in neuroendocrine tumors (NETs) and islets of the multiple endocrine neoplasia 1 protein (MEN1) mouse as well as in the serum of patients with pancreatic NETs associated with glucagonoma syndrome.

  9. Although mice lacking Men1 developed insulinomas as expected, elimination of ARC (zeige NOL3 ELISA Kits) in this context did not significantly alter tumor load. Cellular rates of proliferation and death in these tumors were also not perturbed in the absence of ARC (zeige NOL3 ELISA Kits).

  10. The study characterized the binding position of Ezh2 and menin at all annotated genes in embryonic stem cells and B and T lymphocytes.

MEN1 Antigen-Profil

Beschreibung des Gens

This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with MEN1

  • multiple endocrine neoplasia I (MEN1) Elisa Kit
  • multiple endocrine neoplasia I (men1) Elisa Kit
  • multiple endocrine neoplasia 1 (Men1) Elisa Kit
  • multiple endocrine neoplasia I (Men1) Elisa Kit
  • AW045611 Elisa Kit
  • meai Elisa Kit
  • menin Elisa Kit
  • scg2 Elisa Kit

Bezeichner auf Proteinebene für MEN1

menin , multiple endocrine neoplasia protein , multiple endocrine neoplasia 1 , multiple endocrine neoplasia I , menin-like

4221 Homo sapiens
483758 Canis lupus familiaris
539431 Bos taurus
549115 Xenopus (Silurana) tropicalis
692344 Felis catus
743979 Pan troglodytes
100158320 Xenopus laevis
100411101 Callithrix jacchus
100441476 Pongo abelii
100472417 Ailuropoda melanoleuca
100523533 Sus scrofa
100538227 Danio rerio
17283 Mus musculus
29417 Rattus norvegicus
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