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Mechanistic investigations reveal that AJUBA specifically binds the FERM domain of JAK1 (zeige JAK1 Proteine) to dissociate JAK1 (zeige JAK1 Proteine) from the IFNgamma recepter, resulting in an inhibition of STAT1 (zeige STAT1 Proteine) phosporylation and concomitantly its nuclear translocation. Clinically, the level of AJUBA in CRC (zeige CALR Proteine) specimens is negatively correlated with the levels of IFIT2 (zeige IFIT2 Proteine) and pSTAT1
AJUBA is a LIM domain protein and contributes to the formation and stability of cadherin-mediated cell-cell adhesion. Loss of AJUBA enhances Prostate cancer cell migration and downregulation of AJUBA expression is observed in metastatic Prostate cancer.
Mutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinomas to treatment with PLK1 inhibitors.
mitotic phosphorylation of Ajuba is sufficient to promote cell proliferation and anchorage-independent growth in vitro and tumorigenesis in vivo
The results in this study uncovered that JUB was a regulator involved in proliferation of glioma cells, and it could be used as a potential therapeutic target for glioma.
AJUBA negatively regulates YAP activity through the LATS family, and inactivation of AJUBA is a novel key mechanism in malignant mesothelioma cell proliferation
the LIM protein JUB serves as a tumor-promoting gene in colorectal cancer by promoting epithelial-mesenchymal transition, a critical process of metastasis.
The LIM (zeige PDLIM5 Proteine) domain of Ajuba can competitively bind to the N-terminal of Aurora-A (zeige AURKA Proteine), and inhibited the interaction between N-terminal and C-terminal of Aurora A (zeige AURKA Proteine).
A Rac-PAK1-Ajuba feedback loop integrates spatiotemporal signaling with actin remodeling at cell-cell contacts and stabilizes preassembled cadherin complexes.
Ajuba contains functional nuclear-receptor interacting motifs and selectively interacts with retinoic acid receptors and rexinoid receptor subtypes.
Ajuba recruits p300/CBP (zeige CREBBP Proteine) via its LIM (zeige PDLIM5 Proteine) domain and facilitates p300/CBP (zeige CREBBP Proteine) binding to PPARg (zeige PPARG Proteine). Moreover, Ajuba, PPARg (zeige PPARG Proteine), p300/CBP (zeige CREBBP Proteine) can cooperatively occupy the PPARg (zeige PPARG Proteine) target promoters and concomitantly increases histone acetylation at these loci.
Ajuba is a novel coactivator for liver X receptors and may play important role in lipid and glucose metabolism.
Findings support the importance of adhesion molecules (VE-cadherin and CD31), survivin, and Ajuba in modulating the Hippo pathway, which regulates, in part, proliferation and survival in hemangioendotheliomas.
PKD1-mediated phosphorylation of SNAI1 occurs in the nucleus and generates a nuclear, inactive DNA/SNAI1 complex that shows decreased interaction with its co-repressor Ajuba.
This paper presents evidence indicating that the human and mouse Ajuba is a new cytosolic component of the IL-1 (zeige IL1A Proteine) signaling pathway, influencing the assembly and activity of the aPKC/p62 (zeige GTF2H1 Proteine)/TRAF6 (zeige TRAF6 Proteine) multiprotein signaling complex.
identification of the protein arginine methyltransferase 5 (PRMT5 (zeige PRMT5 Proteine)) as an effector recruited to SNAIL (zeige SNAI1 Proteine) through an interaction with AJUBA that functions to repress the SNAIL (zeige SNAI1 Proteine) target gene, E-cadherin (zeige CDH1 Proteine)
cytoplasmic LIM protein that binds glial glutamate transporter GLT-1 and is proposed to allow glial glutamate transporter GLT-1 to regulate intracellular signaling or interact with the cytoskeleton
LIM domain-containing protein ajuba
, jub, ajuba homolog
, protein ajuba
, Ajuba protein
, ajuba homolog