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Human ICAM-1 Protein expressed in Human Cells - ABIN2002637
Bhalla, Chugh, Mehrotra, Rathore, Tousif, Prakash Dwivedi, Prakash, Kumar Samuchiwal, Kumar, Kumar Singh, Ghanwat, Kumar, Das, Mohmmed, Malhotra, Ranganathan: Host ICAMs play a role in cell invasion by Mycobacterium tuberculosis and Plasmodium falciparum. in Nature communications 2015
PTPN22 (zeige PTPN22 Proteine) colocalized with its substrates at the leading edge of cells migrating on surfaces coated with the LFA-1 (zeige ITGAL Proteine) ligand intercellular adhesion molecule-1 (ICAM-1).
These results suggest that SHP-2-via association with ICAM-1-mediates ICAM-1-induced Src activation and modulates VE-cadherin switching association with ICAM-1 or actin, thereby negatively regulating neutrophil adhesion to endothelial cells and enhancing their transendothelial migration.
Following transepithelial migration, neutrophils adhesion to ICAM-1 resulted in activation of Akt (zeige AKT1 Proteine) and beta-catenin (zeige CTNNB1 Proteine) signaling, increased epithelial-cell proliferation, and wound healing.
P-Selectin and ICAM-1 have roles in mediating THP-1 monocyte adhesion
Dissection of the molecular mechanism revealed that the p38 (zeige CRK Proteine)-Notch1 (zeige NOTCH1 Proteine) axis was the main downstream signaling pathway in CD54-mediated regulation of cancer stem cells in prostate cancers.
We show that knockdown of the expression of mcircRasGEF1B reduces LPS (zeige IRF6 Proteine)-induced ICAM-1 expression. Additionally, we demonstrate that mcircRasGEF1B regulates the stability of mature ICAM-1 mRNAs.
Buerger's patients had a significant increase in circulating HMGB-1 (zeige HMGB1 Proteine), MMP-9 (zeige MMP9 Proteine) and ICAM-1.
SNP rs5498 in ICAM-1 gene and IVS5-13insC variant in HMGA1 (zeige HMGA1 Proteine) gene were not associated with the susceptibility of DR in the Chinese T2DM cohort.
his study shows that two adhesion molecules, shed as soluble forms, are elevated during the acute phase of leptospirosis: E-selectin (zeige SELE Proteine) and s-ICAM1. These molecules may interfere with the process of immune cell recruitment to clear Leptospira at tissue levels.
data suggest that CD2AP (zeige Cd2ap Proteine) acts as a negative regulator of ICAM-1 clustering, which limits the formation of ICAM-1 adhesion complexes to prevent uncontrolled neutrophil adhesion and transcellular transmigration.
in T cells, PI3Kdelta attenuates the activation of Rac1, but sustains the activation of Rap1.
Blocking CD54 inhibited NK cell-mediated cytotoxicity of the GM-CSF (zeige CSF2 Proteine)-stimulated Flt3 ligand (zeige FLT3LG Proteine) conventional dendritic cells. NK cell-mediated lysis of GM-CSF (zeige CSF2 Proteine)-stimulated cDCs was, in part, a result of increased expression of CD54.
These results indicate that, whereas T cells use ICAM-1 and -2 for temporary pulmonary entrapment, neutrophils get sequestered and extravasate into inflamed lungs independent of ICAMs.
This study indicates that the ANG II (zeige AGT Proteine) effects are, in part, mediated or triggered by Gal-3 (zeige LGALS3 Proteine) together with the related intercellular signaling (ICAM-1 and IL-6 (zeige IL6 Proteine)), leading to cardiac inflammation and fibrosis.
Data suggest CKIP1 (casein kinase 2 interacting protein-1) plays role in resistance to oxidative stress in glomerular mesangial cells in development of diabetic nephropathy; mechanisms appear to include down-regulation of expression of ICAM1 (intercellular adhesion molecule-1) and fibronectin (zeige FN1 Proteine) plus activation of Nrf2 (zeige NFE2L2 Proteine)/ARE (nuclear factor E2-related factor 2/antioxidant response element) antioxidative stress pathway.
ICAM1 regulates pathological cardiac remodeling by mediating proinflammatory leukocyte infiltration in the left ventricle and cardiac fibrosis and dysfunction.
Its antiatherogenic impact might be associated with a suppressed adhesion to the endothelium due to down-regulation of endothelial ICAM-1 expression.
ADMA has potent adverse effects on cell proliferation, intracellular ROS (zeige ROS1 Proteine) generation, cell permeability, levels of ICAM-1, and the tight-junction protein occludin (zeige OCLN Proteine)
Neutrophil lung infiltrations in porcine reproductive and respiratory syndrome virus infection infected animals is both ICAM-1 dependent and independent.
Chitosan oligosaccharides downregulate the expression of E-selectin (zeige SELE Proteine) and ICAM-1 by inhibiting the phosphorylation of Mitogen-Activated Protein Kinases and the activation of NF-kappaB (zeige NFKB1 Proteine) in lipopolysaccharides treated porcine iliac artery endothelial cells.
Data show that all five molecules, BNP, ICAM-1, TNF-alpha (zeige TNF Proteine), VCAM-1 (zeige VCAM1 Proteine) and IL-6 (zeige IL6 Proteine), quickly and reliably signaled adverse interactions.
Altered shear stress stimulates upregulation of endothelial VCAM-1 (zeige VCAM1 Proteine) and ICAM-1 in a BMP-4 (zeige BMP4 Proteine)- and TGF-beta1 (zeige TGFB1 Proteine)-dependent pathway.
ICAM1 and IL10 (zeige IL10 Proteine) were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 (zeige JUN Proteine) may be responsible for this upregulation.
Hepatocellular glycogen (zeige GYS1 Proteine) decreases the expression of ICAM-1 mRNA of hepatic stellate cells.
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor.
intercellular adhesion molecule 1
, intercellular adhesion molecule 1-like
, cell surface glycoprotein P3.58
, intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
, major group rhinovirus receptor
, leukocyte adhesion molecule