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removal of the the Gata1 methylation-determining region -mediated silencing machinery is the molecular basis of the initial activation of the Gata1 gene and erythropoiesis.
Results show that GATA1 recognizes a single GATA motif or a composite of adjacent GATA motifs and exerts its diversified bindings. These binding configurations serve as one of the critical determinants of specific transcriptional regulation.
deletion of P-sel disrupted megakaryocyte/neutrophil interactions in spleen, reduced TGF-beta (zeige TGFB1 Proteine) content, and corrected the hematopoietic stem cells distribution that in Gata1(low) mice, as in primary myelofibrosis patients, is abnormally expanded in spleen.
findings suggest that Gata1 & PU.1 transcription factors are only executing and reinforcing lineage choice once made. These results challenge the current prevailing model of early myeloid lineage choice
GATA1 and PU.1 bind in vitro and in vivo the proximal promoter region of the RPS19 (zeige RPS19 Proteine) gene which is frequently mutated in Diamond-Blackfan Anemia.
TAL1 (zeige TAL1 Proteine) and GATA1 form a precisely organized complex at a compound motif consisting of a TG 7 or 8 bp upstream of a WGATAA motif across thousands of genomic locations
We propose that the CID (zeige CENPA Proteine)-dependent dimerization system combined with the EpoR (zeige EPOR Proteine) intracellular domain and the Gata1 gene regulatory region generates a novel peroral strategy for the treatment of anemia.
immunoprecipitation. Our data provide new insights into the expanded regulatory circuitry that coordinates Nanog expression.
Scrib is a novel proinflammatory regulator in endothelial cells, which maintains the protein expression of GATA-like protein-1 (zeige ZGLP1 Proteine).
Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells
Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence within regulatory regions of globin genes and of other genes expressed in erythroid cells.
GATA-binding factor 1
, GATA-binding protein 1
, NF-E1 DNA-binding protein
, erythroid transcription factor
, GATA-binding protein 1 (globin transcription factor 1)