Selenoprotein W, 1 Proteine (SEPW1)

Selenoprotein W, 1 Proteine (SEPW1)
Auf finden Sie aktuell 11 Selenoprotein W, 1 (SEPW1) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Selenoprotein W, 1 Antikörper (27) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 38 Selenoprotein W, 1 Produkte verfügbar.
cb694, fe37b06, selW, selw1, SEPW, sepw1, wu:fe37b06, wu:fk70h03, zgc:109781
alle Proteine anzeigen Gen GeneID UniProt
SEPW1 25545 P63301
SEPW1 6415 P63302
SEPW1 20364 P63300

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Weitere Proteine zu Selenoprotein W, 1 Interaktionspartnern

Chimpanzee Selenoprotein W, 1 (SEPW1) Interaktionspartner

  1. Selenoprotein W is conserved in human, rhesus monkey, sheep, rat, and mouse.

Human Selenoprotein W, 1 (SEPW1) Interaktionspartner

  1. SelW may have a regulatory function in redox cell signaling by interacting with 14-3-3 protein (zeige YWHAE Proteine).

  2. Suppression of EGFR (zeige EGFR Proteine) ubiquitination by SEPW1 may be related to the putative increase in cancer risk associated with high selenium intakes.

  3. In response to selenium compounds, SepW1 synthesis increased at the protein and the mRNA levels.

  4. SEPW1 silencing increases MKK4 (zeige MAP2K4 Proteine), which activates p38gamma (zeige MAPK12 Proteine), p38delta, and JNK2 (zeige MAPK9 Proteine) to phosphorylate p53 (zeige TP53 Proteine) on Ser (zeige SIGLEC1 Proteine)-33 and cause a transient G(1) arrest.

  5. p53 (zeige TP53 Proteine) was increased in SEPW1 silenced cells and was inversely correlated with SEPW1 mRNA in cell lines with altered SEPW1 expression.

  6. The present work shows that SEPW1 facilitates the G1 to S-phase transition by down-regulating expression of the cyclin-dependent kinase (zeige CDK1 Proteine) inhibitor p21 (zeige CDKN1A Proteine)

  7. The gene lacks canonical TATA and CAAT boxes, but has numerous Sp1 (zeige PSG1 Proteine) consensus binding sites upstream of multiple transcription start sites. SEPW1 is expressed in all of the 22 tissues assayed, and shows highest expression in skeletal muscle and heart.

  8. SelW expression in the colon is highly sensitive to Se-depletion

  9. SeW is the novel molecular target of MeHg in human neuronal cells and down-regulation of this selenoenzyme by MeHg is dependent not on generation of ROS (zeige ROS1 Proteine) but on depletion of GSH.

  10. SEPW1 mRNA levels were maximal during G1-phase, dropped after the G1/S transition and increased again after G2/M-phase.

Mouse (Murine) Selenoprotein W, 1 (SEPW1) Interaktionspartner

  1. SelW enhances myoblast differentiation by inhibiting TAZ (zeige TAZ Proteine) binding to 14-3-3 (zeige YWHAQ Proteine).

  2. SelW gene was activated by the binding of MyoD (zeige MYOD1 Proteine) to a specific E-box during early skeletal muscle differentiation.

  3. The main function of SelW in muscle cells is not in the antioxidative system.

  4. Data show that the loss of SelT (zeige SELT Proteine) elevates expression of another selenoprotein, selenoprotein W, suggesting that SepW1 may functionally compensate for SelT (zeige SELT Proteine).

  5. Selenoprotein W is involved in muscle growth and differentiation by protecting the developing myoblasts from oxidative stress

  6. increased in mouse brains of postnatal day 8 and 20 relative to embryonic day 15; siRNA-transfected neurons are more sensitive to the oxidative stress-induced (zeige SQSTM1 Proteine) apoptosis

Selenoprotein W, 1 (SEPW1) Protein Überblick

Protein Überblick

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein shows highest expression in skeletal muscle and heart, and may be involved in oxidation-reduction reactions. A retroprocessed pseudogene, SEPW1P, has been identified and mapped to chromosome 1p35-34.

Alternative names and synonyms associated with Selenoprotein W, 1 (SEPW1)

  • selenoprotein W, 1 (SEPW1)
  • selenoprotein W, 1 (sepw1)
  • selenoprotein W, 1 (Sepw1)
  • selenoprotein W, muscle 1 (Sepw1)
  • cb694 Protein
  • fe37b06 Protein
  • selW Protein
  • selw1 Protein
  • SEPW Protein
  • sepw1 Protein
  • wu:fe37b06 Protein
  • wu:fk70h03 Protein
  • zgc:109781 Protein

Bezeichner auf Proteinebene für Selenoprotein W, 1 Proteine (SEPW1)

selenoprotein W , selenoprotein W, 1 , selenoprotein W, muscle 1 , selW

523694 Bos taurus
612109 Canis lupus familiaris
100050195 Equus caballus
100145402 Xenopus (Silurana) tropicalis
100286805 Pan troglodytes
100410801 Callithrix jacchus
100462742 Ciona intestinalis
100483337 Ailuropoda melanoleuca
25545 Rattus norvegicus
6415 Homo sapiens
100310814 Gallus gallus
397032 Sus scrofa
101119329 Ovis aries
718370 Macaca mulatta
100174175 Pongo abelii
352915 Danio rerio
20364 Mus musculus
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