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NUMB Proteine (NUMB)

Bezeichnung:
Numb Homolog Proteine (NUMB)
Auf www.antikoerper-online.de finden Sie aktuell 11 Numb Homolog (NUMB) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen NUMB Antikörper (179) und NUMB Kits (1) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 206 NUMB Produkte verfügbar.
Synonyme:
C14orf41, c14_5527, Nb, S171
alle Proteine anzeigen Gen GeneID UniProt
NUMB 18222 Q9QZS3
NUMB 8650 P49757
NUMB 29419  

Weitere Synonyme anzeigen

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Weitere Proteine zu NUMB Interaktionspartnern

Mouse (Murine) Numb Homolog (NUMB) Interaktionspartner

  1. role in the mediation of TCR degradation

  2. miR (zeige MLXIP Proteine)-34a directly suppresses Numb in early-stage colon cancer stem cells (CCSCs), forming an incoherent feedforward loop (IFFL) targeting Notch (zeige NOTCH1 Proteine) to separate stem and non-stem cell fates robustly.

  3. Novel Role of Numb as A Regulator of Pro-inflammatory Cytokine Production in Macrophages in Response to Toll-like Receptor 4 (zeige TLR4 Proteine).

  4. Loss of Numb induces a p53 (zeige TP53 Proteine)-dependent senescence following skeletal muscle injury.

  5. Numb is a regulator for constitutive expression and dynamic transport of mGlu1 (zeige GRM1 Proteine).

  6. we observed a glial reaction and an activity-dependent modification of Shh (zeige SHH Proteine), Noggin (zeige NOG Proteine), and Numb proteins. we found that Shh (zeige SHH Proteine) and Noggin (zeige NOG Proteine) could affect motor performance and that these proteins could be associated with both TDP-43 (zeige TARDBP Proteine) and Numb

  7. Numb ensures the asymmetric outcome of self-renewing divisions by partitioning into the progeny that retains the stem cell identity, where it sustains high p53 (zeige TP53 Proteine) activity.

  8. findings demonstrate that Nb and Nbl are intrinsic factors crucial for the renewal of CPCs in the PA2 and that the PA2 serves as a microenvironment for their expansion

  9. Numb/Numbl (zeige NUMBL Proteine) control VEGF receptor (zeige FLT1 Proteine) endocytosis, signaling, and recycling in endothelial cells, which promotes the angiogenic growth of blood vessels.

  10. Nuclear localization of Numb in early thymocyte precursors favors p53 (zeige TP53 Proteine) nuclear stabilization, whereas pre-T-cell receptor (zeige PTCRA Proteine)-dependent Numb nuclear exclusion promotes the p53 (zeige TP53 Proteine) downmodulation essential for further differentiation.

Human Numb Homolog (NUMB) Interaktionspartner

  1. High expression of Numb is associated with radiation resistance in pancreatic cancer.

  2. Upregulated expression of Numb is associated with reduced radiosensitivity of lung cancer.

  3. Radiation sensitivity of NSCLC stem cells was enhanced with the increase of Numb expression.

  4. PNA-antimiR-182 reduced the levels of NICD (zeige NOTCH1 Proteine), Hes1, HIF-1alpha (zeige HIF1A Proteine), and p-Akt (zeige AKT1 Proteine) in both cell groups, while it augmented the intracellular content of FOXO1 (zeige FOXO1 Proteine) and Numb suppressor proteins. In other words, PNA-antimiR-182-mediated upregulation of Numb was associated with downregulation of HIF-1alpha (zeige HIF1A Proteine) and Hes1. Consequently, downregulation of miR (zeige MLXIP Proteine)-182 might find therapeutical value for overcoming trastuzumab resistance

  5. Dominant negative NUMB expression confers a high proliferative phenotype to chronic myeloid leukemia (zeige BCL11A Proteine) cells.

  6. Alternative splicing of APP (zeige APP Proteine), VEGFA (zeige VEGFA Proteine) and NUMB may play an important role in pathogenesis of pancreatic ductal adenocarcinoma.

  7. Notch1 (zeige NOTCH1 Proteine)/Numb/Snail (zeige SNAI1 Proteine) signal pathway plays an important role in the pathogenesis of adenomyosis.

  8. Numb polymorphisms are associated with coronary artery disease among Han Chinese and Uighur Chinese in Xinjiang, China.

  9. Methylation of the Numb promoter contributed to hepatocarcinogenesis.

  10. results indicated that both rs2108552 and rs17781919 in the Numb gene were associated with total cholesterol level and density lipoprotein-cholesterol level in Chinese subjects.

NUMB Protein Überblick

Protein Überblick

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with NUMB

  • numb gene homolog (Drosophila) (Numb)
  • numb homolog (Drosophila) (NUMB)
  • numb homolog (Drosophila) (Numb)
  • C14orf41 Protein
  • c14_5527 Protein
  • Nb Protein
  • S171 Protein

Bezeichner auf Proteinebene für Numb Homolog Proteine (NUMB)

protein numb homolog , h-Numb , numb gene homolog

GENE ID SPEZIES
18222 Mus musculus
480381 Canis lupus familiaris
395639 Gallus gallus
8650 Homo sapiens
29419 Rattus norvegicus
512187 Bos taurus
100522019 Sus scrofa
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