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Data suggest that Numb acts as a Notch (zeige NOTCH1 Proteine) antagonist by controlling intracellular destination and stability of the Notch ligand (zeige JAG2 Proteine) Delta-like (zeige DLK1 Proteine) 4 (DLL4 (zeige DLL4 Proteine)) through a post-endocytic sorting process; Numb negatively controls DLL4 (zeige DLL4 Proteine) plasma membrane recycling through well-documented recycling regulator protein AP1 (zeige JUN Proteine).
NUMB is necessary for establishing polarity in coelomic epithelium cells.
investigations revealed that NUMB and NUMBL (zeige NUMBL Proteine) interacted with small GTPase (zeige RACGAP1 Proteine) Rab7 (zeige RAB7A Proteine) to transition ERBB2 (zeige ERBB2 Proteine) from early to late endosome for degradation.
These findings highlight the importance of Numb and Numbl (zeige NUMBL Proteine) in the control of myoepithelial cell fate determination, epithelial identity, and lactogenesis
RBM4 (zeige RBM4 Proteine) depletion reduced the expression of the proneural gene Mash1 (zeige ASCL1 Proteine), and such reduction was reversed by an RBM4 (zeige RBM4 Proteine)-induced Numb isoform containing exon 3 but lacking exon 9. RBM4 (zeige RBM4 Proteine) was also essential for neurite outgrowth from cortical neurons in vitro. Neurite outgrowth defects of RBM4 (zeige RBM4 Proteine)-depleted neurons were rescued by RBM4 (zeige RBM4 Proteine)-induced exon 9-lacking Numb isoforms. RBM4 (zeige RBM4 Proteine) modulates exon selection of Numb.
role in the mediation of TCR degradation
miR (zeige MLXIP Proteine)-34a directly suppresses Numb in early-stage colon cancer stem cells (CCSCs), forming an incoherent feedforward loop (IFFL) targeting Notch (zeige NOTCH1 Proteine) to separate stem and non-stem cell fates robustly.
Novel Role of Numb as A Regulator of Pro-inflammatory Cytokine Production in Macrophages in Response to Toll-like Receptor 4 (zeige TLR4 Proteine).
Loss of Numb induces a p53 (zeige TP53 Proteine)-dependent senescence following skeletal muscle injury.
Numb is a regulator for constitutive expression and dynamic transport of mGlu1 (zeige GRM1 Proteine).
Data suggest that over-expression of NUMB has anti-cancer effects to prostatic cancer cells; these studies included experiments both in vitro and in vivo (xenograft experiments in nude mice).
Using patient-derived xenografts, the study shows that expansion of the cancer stem cells pool, due to altered self-renewing divisions, is also a feature of Numb-deficient human breast cancers .
Numb binds to another docking regulator, Mon1b, and is required for the recruitment of cytosolic Mon1b to the early endosomes membrane.
Low NUMB expression is associated with pancreatic cancer.
Together, our findings revealed a novel function of Numb and its likely mechanism in regulation of autophagy events.
investigations revealed that NUMB and NUMBL (zeige NUMBL Proteine) interacted with small GTPase (zeige RACGAP1 Proteine) Rab7 (zeige RAB7B Proteine) to transition ERBB2 (zeige ERBB2 Proteine) from early to late endosome for degradation.
Our evidence supports a mechanism by which Numb AS is regulated in response to oncogenic signaling pathways, and contributes to activation of downstream pathways to promote tumorigenesis.
Numb is a pivotal adaptor protein that mediates the subcellular localization of EAAT3 (zeige SLC1A1 Proteine) through binding the YxNxxF (where x stands for any amino acid) motif.
HBeAg and its precursors promote HDM2-mediated degradation and impair transcriptional activity of p53 (zeige TP53 Proteine) by interacting with NUMB, consequently contributing to hepatocellular carcinoma development.
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.
protein numb homolog
, numb gene homolog