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role in the mediation of TCR degradation
miR (zeige MLXIP Proteine)-34a directly suppresses Numb in early-stage colon cancer stem cells (CCSCs), forming an incoherent feedforward loop (IFFL) targeting Notch (zeige NOTCH1 Proteine) to separate stem and non-stem cell fates robustly.
Novel Role of Numb as A Regulator of Pro-inflammatory Cytokine Production in Macrophages in Response to Toll-like Receptor 4 (zeige TLR4 Proteine).
Loss of Numb induces a p53 (zeige TP53 Proteine)-dependent senescence following skeletal muscle injury.
Numb is a regulator for constitutive expression and dynamic transport of mGlu1 (zeige GRM1 Proteine).
we observed a glial reaction and an activity-dependent modification of Shh (zeige SHH Proteine), Noggin (zeige NOG Proteine), and Numb proteins. we found that Shh (zeige SHH Proteine) and Noggin (zeige NOG Proteine) could affect motor performance and that these proteins could be associated with both TDP-43 (zeige TARDBP Proteine) and Numb
Numb ensures the asymmetric outcome of self-renewing divisions by partitioning into the progeny that retains the stem cell identity, where it sustains high p53 (zeige TP53 Proteine) activity.
findings demonstrate that Nb and Nbl are intrinsic factors crucial for the renewal of CPCs in the PA2 and that the PA2 serves as a microenvironment for their expansion
Numb/Numbl (zeige NUMBL Proteine) control VEGF receptor (zeige FLT1 Proteine) endocytosis, signaling, and recycling in endothelial cells, which promotes the angiogenic growth of blood vessels.
Nuclear localization of Numb in early thymocyte precursors favors p53 (zeige TP53 Proteine) nuclear stabilization, whereas pre-T-cell receptor (zeige PTCRA Proteine)-dependent Numb nuclear exclusion promotes the p53 (zeige TP53 Proteine) downmodulation essential for further differentiation.
High expression of Numb is associated with radiation resistance in pancreatic cancer.
Upregulated expression of Numb is associated with reduced radiosensitivity of lung cancer.
Radiation sensitivity of NSCLC stem cells was enhanced with the increase of Numb expression.
PNA-antimiR-182 reduced the levels of NICD (zeige NOTCH1 Proteine), Hes1, HIF-1alpha (zeige HIF1A Proteine), and p-Akt (zeige AKT1 Proteine) in both cell groups, while it augmented the intracellular content of FOXO1 (zeige FOXO1 Proteine) and Numb suppressor proteins. In other words, PNA-antimiR-182-mediated upregulation of Numb was associated with downregulation of HIF-1alpha (zeige HIF1A Proteine) and Hes1. Consequently, downregulation of miR (zeige MLXIP Proteine)-182 might find therapeutical value for overcoming trastuzumab resistance
Dominant negative NUMB expression confers a high proliferative phenotype to chronic myeloid leukemia (zeige BCL11A Proteine) cells.
Alternative splicing of APP (zeige APP Proteine), VEGFA (zeige VEGFA Proteine) and NUMB may play an important role in pathogenesis of pancreatic ductal adenocarcinoma.
Notch1 (zeige NOTCH1 Proteine)/Numb/Snail (zeige SNAI1 Proteine) signal pathway plays an important role in the pathogenesis of adenomyosis.
Numb polymorphisms are associated with coronary artery disease among Han Chinese and Uighur Chinese in Xinjiang, China.
Methylation of the Numb promoter contributed to hepatocarcinogenesis.
results indicated that both rs2108552 and rs17781919 in the Numb gene were associated with total cholesterol level and density lipoprotein-cholesterol level in Chinese subjects.
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.
protein numb homolog
, numb gene homolog