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Human TXN Protein expressed in Escherichia coli (E. coli) - ABIN666978
Lundström, Holmgren: Protein disulfide-isomerase is a substrate for thioredoxin reductase and has thioredoxin-like activity. in The Journal of biological chemistry 1990
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the overexpression of thioredoxin,S100-A10 and S100-A6 specifically distinguished metastatic from non-metastatic tumors
Thioredoxin-h5 (TRXh5) reverses SNO modifications by acting as a selective protein-SNO reductase.
Data indicate that thioredoxin h proteins are not required to prevent the spontaneous activation of S-locus receptor kinase (SRK (zeige ZAP70 Proteine)) in the stigma.
Redox regulation of AtCPK21 by Trx-h1 in Arabidopsis thaliana in response to external stimuli is important for appropriate cellular responses.
in LOV1's absence, victorin inhibits TRX-h5, resulting in compromised defense but not disease by C. victoriae; in LOV1's presence, victorin binding to TRX-h5 activates LOV1 and elicits a resistance-like response that confers disease susceptibility
Structral model of thioredoxin h1 from Arabidopsis thaliana in the oxidized state displays the conserved thioredoxin fold.
Data show that thioredoxin h5 (ATTRX5), but not ATTRX3, is highly induced in sensitive Arabidopsis following victorin treatment.
regulation of NPR1 is through the opposing action of S-nitrosoglutathione and thioredoxins; findings suggest a link between pathogen-triggered redox changes and gene regulation in plant immunity
Study shows that TRX1 (zeige MLL Proteine) and APEX1 (zeige APEX1 Proteine) expressions are up regulated in new Multiple Sclerosis (MS) patients compared to controls and might be implicated in pathogenesis of the disease.
CD40 (zeige CD40 Proteine) activation resulted in down-regulation of Thioredoxin (Trx)-1 to permit ASK1 (zeige MAP3K5 Proteine) activation and apoptosis. Although soluble receptor (zeige IFNAR1 Proteine) agonist alone could not induce death, combinatorial treatment incorporating soluble CD40 (zeige CD40 Proteine) agonist and pharmacological inhibition of Trx-1 (zeige MLL Proteine) was functionally equivalent to the signal triggered by mCD40L
our findings identify the TXN-FOXO1 (zeige FOXO1 Proteine)-p300 (zeige EP300 Proteine) circuit as the sensor and effector of oxidative stress in DLBCL cells
Novel positive feedback loop between Trx-1 (zeige MLL Proteine) and S100P (zeige S100P Proteine) promotes colorectal cancer invasion and metastasis.
Thioredoxin attenuates oxidized low-density lipoprotein induced oxidative stress in human umbilical vein endothelial cells by reducing NOX2 (zeige CYBB Proteine)-NOX4 (zeige NOX4 Proteine) activity.
from the two catalytic cysteines of TRX1 (zeige MLL Proteine) the residue C32 is responsible for the high-affinity binding of TRX1 (zeige MLL Proteine) to the ASK1 (zeige MAP3K5 Proteine)-TRX (zeige VAC14 Proteine)-binding domain in reducing conditions
findings suggest that the up-regulated RRM1 (zeige RRM1 Proteine) and hTrx1 (zeige MLL Proteine) in colorectal cancer directly interact with each other and promote RR activity, resulting in enhanced DNA synthesis and cancer malignancy.
findings support the potential pathophysiological relevance of TRX (zeige VAC14 Proteine) in celiac disease and establish the Cys (zeige DNAJC5 Proteine)(370)-Cys (zeige DNAJC5 Proteine)(371) disulfide bond of TG2 (zeige TGM2 Proteine) as one of clearest examples of an allosteric disulfide bond in mammals.
Trx (zeige VAC14 Proteine) and its target proteins involved in redox signaling are critical for the control of cell fate such as cell survival and apoptosis [review]
herefore, the length of treatment with Nrf2 (zeige GABPA Proteine) activators and/or Trx-1 (zeige MLL Proteine) has first to be studied in more detail in cardiovascular disorders. Moreover, a combination of Nrf2 (zeige GABPA Proteine) activators and Trx-1 (zeige MLL Proteine) should be investigated and taken into consideration.
single-marker and haplotype analyses revealed significant effects of TXNIP (zeige TXNIP Proteine) on hot carcass weight, test daily gain, and lifetime daily gain
Trx1 enhances blood perfusion and increases angiogenic protein expression in a rodent hind limb ischemia model.
GSR (zeige GSR Proteine) is not essential for the maintenance of antioxidant defenses in mouse cochlea; the thioredoxin/thioredoxin reductase (zeige PRDX2 Proteine) system can probably operate as a functional backup for GSR (zeige GSR Proteine).
These results strongly suggest that Trx1 ameliorates the myocardial effects of I/R by improving the free radical-mediated damage in cardiac and mitochondrial function, opening the possibility of new therapeutic strategies in coronary artery disease.
findings support the potential pathophysiological relevance of TRX in celiac disease and establish the Cys (zeige DNAJC5 Proteine)(370)-Cys (zeige DNAJC5 Proteine)(371) disulfide bond of TG2 (zeige TGM2 Proteine) as one of clearest examples of an allosteric disulfide bond in mammals.
Thioredoxin-mediated deglutathionylation of eNOS (zeige NOS3 Proteine) in the coronary artery in vivo protected against reperfusion injury, even in the presence of normal levels of glutathione.
Acute stimuli of epinephrine induced Trx-1 expression through activating CREB (zeige CREB1 Proteine).
results suggest that PostC prevents Trx-1 degradation, decreasing oxidative stress and allowing the activation of Akt and GSK3beta to exert its cardioprotective effect
blocking MPTP (zeige PTPN2 Proteine)-mediated TNF (zeige TNF Proteine) signaling through intrathecal administration of TNF (zeige TNF Proteine)-neutralizing antibody prevented Trx1 oxidation and downstream ASK1 (zeige MAP3K5 Proteine)-p38 MAPK (zeige MAPK14 Proteine) activation
GL-V9 attenuated DSS (zeige PMP22 Proteine)-induced colitis against oxidative stress by up-regulating Trx-1 via activation of AMPK (zeige PRKAA1 Proteine)/FOXO3a (zeige FOXO3 Proteine) pathway.
The ventral signal observed from E12.5 onward colocalized with motor neuron markers Isl1 (zeige ISL1 Proteine)/2 and FoxP1 (zeige FOXP1 Proteine). and the strong ventral signal colocalizing with Isl1 (zeige ISL1 Proteine)/2 was observed in all rostrocaudal segments of the spinal cord
The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.
, thioredoxin-like protein
, peptidase C
, ATL-derived factor
, TXN delta 3
, surface-associated sulphydryl protein
, thioredoxin delta 3