PKD2 Proteine (PKD2)

Bezeichnung:
Protein Kinase D2 Proteine (PKD2)
Auf www.antikoerper-online.de finden Sie aktuell 13 Protein Kinase D2 (PKD2) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PKD2 Antikörper (124) und PKD2 Kits (8) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 153 PKD2 Produkte verfügbar.
Synonyme:
AI325941, APKD2, nPKC-D2, Pc-2, PC2, PKD2, PKD4, PRKD2, RGD1308054, TRPP2
alle Proteine anzeigen Gen GeneID UniProt
PKD2 5311 Q13563
PKD2 101540 Q8BZ03
Ratte PKD2 PKD2 292658 Q5XIS9

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Weitere Proteine zu PKD2 Interaktionspartnern

Human Protein Kinase D2 (PKD2) Interaktionspartner

  1. Hyperactivation of the ERK (zeige EPHB2 Proteine) pathway may be caused by down-regulation of PC-1 (zeige PCSK1 Proteine) and PC-2 (zeige KRT6B Proteine) in lymphatic malformations, contributing to increased proliferation of lymphatic endothelial cells.

  2. Annualized median liver growth rates were 1.68, 1.5 and 1.24% for PKD1 (zeige PKD1 Proteine)-T, PKD1 (zeige PKD1 Proteine)-NT and PKD2 mutations, respectively (P = 0.49), and remained unaffected by the ADPKD genotype when adjusted for age, gender and baseline HtLV.

  3. Here, we review previous studies that connect the molecular properties of the domains of PC2 (zeige KRT6B Proteine) Cterm to distinct aspects of PC2 (zeige KRT6B Proteine) functions and regulation.

  4. Data show that in 82 (87.2%) of the patients, pathogenic mutations were detected in PKD1 (zeige PKD1 Proteine) (79.0%-92.5%), whereas in 12 (12.8%) patients pathogenic mutations were detected in PKD2 (7.5%-21.0%).

  5. Two cryo-EM structures of distinct channel states of full-length human PC2 (zeige KRT6B Proteine) in complex with lipids and cations.

  6. The structure of human PC2 (zeige KRT6B Proteine) in a closed conformation, solved by electron cryomicroscopy at 4.2-A resolution.

  7. SNPs in and near PKD2 showed significant evidence of association in individual samples of black adults (rs17013735, P-value=0.0009) and white adults (rs11938025; P-value=0.0005; rs2725270, P-value=0.003).

  8. Pancreatic cysts were more prevalent in patients with ADPKD with PKD2 mutation than in control subjects or patients with PKD1 (zeige PKD1 Proteine) mutation.

  9. This study discovered and characterized a novel, highly conserved N-terminal domain, comprising 92 amino acids, which mediates dimerization of Protein Kinase D (PKD) isoforms, PKD1 (zeige PKD1 Proteine), PKD2, and PKD3 (zeige PRKD3 Proteine) monomers.

  10. This suggests that a precise dosage of PC2 (zeige KRT6B Proteine) is necessary for an adequate mechanosensitive alpha-actinin (zeige ACTN1 Proteine) recruitment at junctions.

Mouse (Murine) Protein Kinase D2 (PKD2) Interaktionspartner

  1. Our studies demonstrate that PKD1 (zeige PKD1 Proteine)/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha (zeige DGKA Proteine) effect on MVB secretory traffic.

  2. Results reveal that whereas protein kinase D1 (zeige PRKD1 Proteine) and protein kinase D2 are essential for neuronal polarity, there exists a functional redundancy between the two proteins.

  3. PKD2 acted as an amplification checkpoint for antigen-stimulated digital cytokine responses and translated the differential strength of TCR signaling to determine the number of naive CD8 (zeige CD8A Proteine)(+) T cells that became effector cells.

  4. Protein kinase D2 promotes in vitro osteoclast differentiation and fusion

  5. A bioinformatic screen identified the serine-threonine kinase (zeige CDK4 Proteine) protein kinase D2 (PRKD2) as a potential effector of GABP in hematopoietic stem cells

  6. Transcriptional profiling reveals the full consequences of PKD2 loss and maps in detail the selective, but critical, function for PKD2 in signalling by alpha/beta mature TCR complexes in peripheral T-cells.

  7. PKD2 is a common signaling target downstream of various agonist receptors in platelets and G(q)-mediated signals along with calcium and novel PKC isoforms, in particular, PKCdelta (zeige PKCd Proteine) activate PKD2 in platelets.

  8. Data demonstrate that, unlike PKD1 (zeige PKD1 Proteine), PKD2 catalytic activity is dispensable for normal embryogenesis.

  9. PKD2, like PKD (zeige PRKD1 Proteine), facilitates mitogenesis in 3T3 cells

PKD2 Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with PKD2

  • protein kinase D2 (PRKD2)
  • polycystic kidney disease 2 (autosomal dominant) (PKD2)
  • protein kinase D2 (Prkd2)
  • AI325941 Protein
  • APKD2 Protein
  • nPKC-D2 Protein
  • Pc-2 Protein
  • PC2 Protein
  • PKD2 Protein
  • PKD4 Protein
  • PRKD2 Protein
  • RGD1308054 Protein
  • TRPP2 Protein

Bezeichner auf Proteinebene für Protein Kinase D2 Proteine (PKD2)

protein kinase D2 , serine/threonine-protein kinase D2-like , R48321 , autosomal dominant polycystic kidney disease type II protein , polycystin-2 , polycystwin , transient receptor potential cation channel, subfamily P, member 2 , serine/threonine-protein kinase D2 , nPKC-D2

GENE ID SPEZIES
468929 Pan troglodytes
782793 Bos taurus
100407181 Callithrix jacchus
100471375 Ailuropoda melanoleuca
5311 Homo sapiens
25865 Homo sapiens
101540 Mus musculus
292658 Rattus norvegicus
484427 Canis lupus familiaris
100517036 Sus scrofa
100355908 Oryctolagus cuniculus
100717067 Cavia porcellus
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