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MicroRNA miR (zeige MYLIP Proteine)-212/132 cluster is actively repressing the expression of mu opioid receptor (Oprm1) by targeting a sequence in the 3' UTR of its mRNA.
demonstrate that zfMOR exhibits a pharmacological profile similar to that of the mammalian MOR.
This study demonstrates that OPRM1 118A>G and the combined OPRM1/COMT (zeige COMT Proteine) genotype are associated with experimental thermal pain sensitivity in a paediatric population.
This study found significant effects for rs563649, but not rs1799971 of OPRM1, the so far most frequently analyzed opioidergic SNP in pain research.
DRD2 (zeige DRD2 Proteine) A2/A1, DRD3 (zeige DRD3 Proteine) Ser9Gly, DbetaH -1021C>T, OPRM1 A118G and GRIK1 (zeige GRIK1 Proteine) rs2832407C>A are not associated with alcoholism alone or in interaction.
The OPRM1 rs1799971 A > G polymorphism is not strongly associated with alcohol-dependence. (Meta-analysis)
that promoter fragments of OPRK1 (zeige OPRK1 Proteine) and OPRM1 were able to upregulate gene expression with mild cognitive impairment
Low OPRM1 expression is associated with L-asparaginase (zeige ASRGL1 Proteine) resistance in pediatric acute lymphoblastic leukemia.
PET imaging with [11C]carfentanil tested the hypotheses that acute cigarette smoking increases release of endogenous opioids in the human brain and that smokers have an upregulation of mu opioid receptors (MORs) when compared to nonsmokers. No significant changes found in binding potential of [11C]carfentanil between the placebo and active cigarette sessions; no differences in MOR binding between smokers and nonsmokers.
These results do not support strong modulatory effects of OPRM1 genetic variation on opioid receptor antagonist attenuation of alcohol- and food-related behaviors.
AG and GG genotypes of OPRM1 rs1799971 were associated with a decreased risk of CVS ( P <0.05). In addition, AG and GG genotypes of OPRM1 rs1799971 were correlated with migraine episodes and a family history of migraines.
Subjects with schizophrenia who had the OPRM1 *G genotype smoked more cigarettes per day than the AA allele carriers with schizophrenia. In bipolar patients, there were no OPRM1 genotype differences in smoking status.
Findings implicate truncated Oprm1 6TM splice variants in analgesic mechanisms and suggest that they may help explain many of the subtle, but important, clinical differences among mu opioids.
The data show that somatic MORs in POMC (zeige POMC Proteine) neurons couple to multiple effectors that have differential sensitivity to desensitization of the receptor.
C termini generated from 3' alternative splicing of the mu opioid receptor gene are pharmacologically distinct.
Double mothering normalized the abnormal response to maternal separation in Oprm1-knockout mice, in an animal model of Autism.
OPRM1, expressed by primary afferent nociceptors, initiates opiate tolerance and opioid-induced hyperalgesia development.
Study reveals dissociable Mu opioid receptors (MOR) functions across mesocorticolimbic networks. Beyond a role in reward processing, operating at the level of local ventral tegmental area neurons, MORs also moderate motivation for appetitive stimuli within forebrain circuits that drive motivated behaviors.
MOR-T394 mutation or polymorphisms could be a risk factor in developing opioid abuse and addiction and therefore be used as a new biomarker in prediction and prevention of opioid abuse and addiction
MOR epigenetic regulation requires multiple coordinated signals converging at the MOR promoter, involving mitogen-activated protein kinase (zeige MAPK1 Proteine) (MAPK (zeige MAPK1 Proteine)) activation and mitogen- and stress-activated protein kinase 1 (zeige RPS6KA5 Proteine).
inhibition of mu-opioid receptor expression blocks morphine and DAMGO increases in the translocation of NF-kB p65 protein in microglia.a low dose of morphine, exerting its effects via the mu-opioid receptor, increases the DNA-binding activity of NF-kB via PKCepsilon, while a high dose of morphine triggers a nonopiate receptor response mediated by TLR4 and, interestingly, PKC signalling
Paternally expressed 11/Retrotransposon-like 1 (Peg11/Rtl1) knockout (KO) mice show mid- to late fetal lethality or late fetal growth retardation associated with frequent neonatal lethality
Coactivation of mu opioid receptors with nociceptin receptors produces synergistic antinociception.
Thisstudy adds to the growing literature showing that variation in the mu-opioid receptor gene OPRM1 is associated with social attachment and rejection.
OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors.
findings suggest a role for OPRM1 variation in the expression of attachment behavior, especially as a function of separation from the caregiver
This gene encodes one of three opioid receptors. The mu opioid receptor is the principal target of endogenous opioid peptides and opioid analgesic agents such a s beta-endorphn and enkephalins. The NM_001008503.1:c.118A>G allele had been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene.
, mu-type opioid receptor
, opioid receptor, mu 1
, mu-opioid receptor
, outer membrane efflux protein
, outer membrane protein OprM
, malate dehydrogenase, mitochondrial
, mu opioid receptor splice variant rMOR-1S
, mu opioid receptor splice variant rMOR-1Z
, opioid receptor B
, micro opioid receptor isoform hMOR-1A2
, mu opiate receptor
, mu opioid receptor hMOR-1a
, MOP receptor
, mu opioid receptor
, mammalian retrotransposon derived protein 1
, paternally expressed gene 11 protein
, retrotransposon-derived protein PEG11
, retrotransposon-like protein 1