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Studies indicate the importance of the AKAP79/PP2B/protein kinase A complex's role in synaptic long-term depression in the CA1 (zeige CA1 Proteine) region of the hippocampus.
Cigarette smoke-induced changes in AKAP5 and AKAP12 in patients with COPD (zeige ARCN1 Proteine) may affect efficacy of pharmacotherapy.
human AKAP79-anchored PKC selectively phosphorylates the Robo3.1 receptor subtype on serine 1330
GPR30 interacted with membrane-associated guanylate kinases and protein kinase A-anchoring protein (AKAP) 5 in the plasma membrane in a PDZ-dependent manner.
a significant role for the AKAP5 scaffold in signaling and trafficking of the beta1-AR in cardiac myocytes and mammalian cells.
Patients with bipolar disorder have higher density of AKAP5-expressing neurons in the anterior cingulate cortex compared with controls.
AKAP79, PKC (zeige PRRT2 Proteine), PKA and PDE4 (zeige PDE4A Proteine) participate in a Gq-linked muscarinic receptor (zeige CHRM5 Proteine) and adenylate cyclase 2 (zeige ADCY2 Proteine) cAMP signalling complex.
The results of this study suggested that antagonizing the TRPV1 (zeige TRPV1 Proteine)-AKAP79 interaction will be a useful strategy for inhibiting inflammatory hyperalgesia.
AKAP5 Pro100Leu effects on emotion processing might be task-dependent with Pro homozygotes showing lower control of emotional interference, but more efficient processing of task-relevant emotional stimuli.
Antagonizing the interaction between AKAP79 and TRPV1 (zeige TRPV1 Proteine) inhibits inflammatory hyperalgesia.
the C-helix of protein kinase A inhibitory regulatory subunit is identified as a highly dynamic switch which relays cyclic AMP (zeige TMPRSS5 Proteine) binding to the helical catalytic-subunit binding regions
AKAP150 regulates Ca(2 (zeige CA2 Proteine)+ )cycling and myocardial ionotropy following pathological stress, promoting pathological remodelling and heart failure propensity.
AKAP150-calcineurin signaling dyad is essential for the activation of the phosphatase and the subsequent down-regulation of Kv channel currents following myocardial infarction.
This study demonstrated that the AKAP150 oordinates metabotropic glutamate (zeige GRIN1 Proteine) receptor sensitization of peripheral sensory neurons.
Thus, our present study revealed that AKAP5 plays a significant role in the regulation of sympathetic nerve activities.
Identify a novel cardioprotective role for AKAP5 that is mediated by regulating the activities of cardiac CaN and CaMKII (zeige CAMK2G Proteine) and highlight a significant role for cardiac beta-ARs (zeige SLURP1 Proteine) in this phenomenon.
endothelial-dependent dilation of resistance arteries is enabled by MEP (zeige CTSL1 Proteine)-localized AKAP150, which ensures the proximity of PKC to TRPV4 (zeige TRPV4 Proteine) channels and the coupled channel gating necessary for efficient communication from endothelial to smooth muscle cells
Our results support a model whereby subcellular anchoring of CaN by AKAP150 is a key molecular determinant of vascular BKCa (zeige KCNMA1 Proteine) channel remodeling, which contributes to vasoconstriction during diabetes mellitus.
Anchoring of protein kinase A and adenylyl cyclase by AKAP5 is important for regulation of postsynaptic functions and specifically AMPA (zeige GRIA3 Proteine) receptor activity.
the direct anchoring of both PKA and AC to TRPV1 (zeige TRPV1 Proteine) by AKAP79/150 facilitates the response to inflammatory mediators and may be critical in the pathogenesis of thermal hyperalgesia.
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.
A kinase (PRKA) anchor protein 5
, A-kinase anchor protein 5
, A-kinase anchor protein 5-like
, a-kinase anchor protein 5-like
, A-kinase anchor protein 79 kDa
, A-kinase anchor protein, 79kDa
, A-kinase anchoring protein 75/79
, AKAP 79
, cAMP-dependent protein kinase regulatory subunit II high affinity binding protein
, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein
, A-kinase anchor protein 75 kDa
, AKAP 75
, anchor protein regulatory subunit (AKAP75)
, A-kinase anchor protein 150 kDa
, AKAP 150
, RII-B-binding protein