Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) Proteine (PTGS2)

Bezeichnung:
Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) Proteine (PTGS2)
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Synonyme:
CEF147, COII, Cox-2, Cox2, GRIPGHS, hCox-2, PGG/HS, PGHS-2, PGHS2, PHS-2, PHSII, PTGS2, TIS10
alle Proteine anzeigen Gen GeneID UniProt
PTGS2 19225 Q05769
PTGS2 29527 P35355
PTGS2 5743 P35354

Weitere Synonyme anzeigen

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Weitere Proteine zu Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) Interaktionspartnern

Horse (Equine) Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) Interaktionspartner

  1. This study showed that COX-1 (zeige PTGS1 Proteine) and COX-2 in genital carcinomas in the horse is poor; microsomal PGES (zeige PTGES Proteine)-1 is more prominently expressed.

  2. Progestin treatment does not affect expression of cytokines, steroid receptors, oxytocin receptor (zeige OXTR Proteine), and cyclooxygenase 2 in fetal membranes and endometrium.

  3. COX-1 (zeige PTGS1 Proteine) and COX-2 genes were constitutively expressed in baseline samples. Low-flow ischemia resulted in significant upregulation of COX-2 gene expression at each subsequent time point, compared with baseline values.

  4. The role for p38 (zeige MAPK14 Proteine) mitogen-activated kinase (MAPK (zeige MAPK1 Proteine)) in the signaling mechanism regulating pro-inflammatory cyclooxygenase (COX (zeige CPOX Proteine)) gene expression in lipopolysaccharide (LPS (zeige IRF6 Proteine))-activated equine leukocytes in horses is reported.

  5. In this study, both COX-1 (zeige PTGS1 Proteine) and COX-2 were expressed in the colon before induced ischemia; ischemic injury increased expression of COX-2.

  6. Immunoreactivity for COX-1 (zeige PTGS1 Proteine) and COX-2 is high in equine corneal SCC (zeige CYP11A1 Proteine), possibly indicating that COX (zeige CPOX Proteine) plays a role in oncogenesis or progression of this tumor type at this site.

  7. It was found that most equine squamous-cell carcinomas and many melanomas appear to express COX-2 and thus could respond to COX-2 inhibitor therapy.

  8. data support the hypothesis that prostaglandin G/H synthase 2(PGHS2)is a target for the antiluteolytic signal produced by equine conceptuses during early pregnancy

Cow (Bovine) Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) Interaktionspartner

  1. The objective of this study was to evaluate the mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS 2), prostaglandin F2alpha synthase (PTGFS) and prostaglandin E2 microsomal synthase 1 (mPTGES 1) in the endometrium of repeat-breeding cows with and without subclinical endometritis.

  2. results indicate that nuclear receptor subfamily 1 group D member 1(REV-ERBalpha (zeige NR1D1 Proteine)) plays an inhibitory role in the expression of prostaglandin-endoperoxide synthase 2(PTGS2) in both bovine USCs and UECs treated with ovarian steroids

  3. This study showed that neutrophils from periparturient heifers show impairment of COX-2 mRNA expression and lactoferrin (zeige LTF Proteine), suggesting that these mechanisms may contribute to immunosuppression in cows around calving.

  4. Exposure to follicular fluid transiently increased the transcript levels of IL8 (zeige IL8 Proteine) and PTGS2, and decreased the expression of SOD2 (zeige SOD2 Proteine), GPX3 (zeige GPX3 Proteine), DAB2 (zeige DAB2 Proteine), and NR3C1 (zeige NR3C1 Proteine). TNF (zeige TNF Proteine) and IL6 (zeige IL6 Proteine) levels were also decreased while those of NAMPT (zeige NAMPT Proteine) were unaffected.

  5. Purinergic P2Y1 receptor (zeige P2RY1 Proteine) signaling mediates wound stimuli-induced cyclooxygenase-2 expression in intestinal subepithelial myofibroblasts

  6. Data suggest that Escherichia coli infections (here, administration of LPS (zeige IRF6 Proteine)) provokes luteolysis in diestrus, non-lactating cows but no change in expression of PTGS2 in corpus luteum and has no effect on luteinization in the following cycle.

  7. This study is the first to report the involvement of PGE2 in oocyte MAPK (zeige MAPK1 Proteine) activation during the maturation process.

  8. Inhibitors of c-Src (zeige SRC Proteine) (PP2, 10 microm) and PI3K (LY294002, 25 microm) produced a significant decrease in oxytocin-induced PGF (zeige PGF Proteine)(2 alpha) production and reduced COX2 expression by endometrial epithelial cells.

  9. COX-2 pathway is responsible for the endometrial production of PGE (zeige LIPF Proteine)(2) in the bovine endometrium during the estrous cycle

  10. the conceptus, through its secretion of IFN-tau, stimulates maternal epithelial expression of COX-2 and GM-CSF (zeige CSF2 Proteine) during the peri (zeige PLIN1 Proteine)-attachment period in the cow.

Mouse (Murine) Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) Interaktionspartner

  1. Salt supplementation during the COX-2-dependent time frame of nephrogenesis partly reverses renal morphological defects in COX-2(-/-) mice and improves kidney function.

  2. Data suggest that induction of Ptgs2 expression in preimplantation uterus may be earliest positive embryo/blastocyst signal for implantation and pregnancy recognition in mice.

  3. the bone regeneration capacity of Cox (zeige CPOX Proteine)-2KO MDSCs was impaired because of a reduction in cell proliferation and survival capacities, reduction in osteogenic differentiation and a decrease in the ability of the cells to recruit host cells to the injury site.

  4. these studies have demonstrated an important but unexpected role for macrophage COX-2/prostaglandin E2/PGE2 receptor subtype 4 signaling to lessen progression of diabetic kidney disease, unlike the pathogenic effects of increased COX-2 expression in intrinsic renal cells.

  5. Data (including data from studies using knockout/mutant mice) suggest that Mir200c (microRNA 200c) is involved in endothelial function/dysfunction via regulation of Cox2 (cyclooxygenase-2) expression; overexpression of Mir200c impairs endothelium-dependent vascular relaxation (EDVR) in non-diabetic mouse aorta, whereas suppression of Mir200c by anti-Mir200c enhances EDVR in diabetic mouse aorta.

  6. data indicate that excessive adipocyte lipolysis activates the JNK (zeige MAPK8 Proteine)/NFkappaB pathway leading to the up-regulation of COX-2 expression and recruitment of inflammatory macrophages.

  7. this study shows that c-Jun (zeige JUN Proteine) regulates the activation state of macrophages and promotes arthritis via differentially regulating cyclooxygenase-2 and arginase-1 (zeige ARG1 Proteine) levels

  8. Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2 (zeige YWHAZ Proteine), lipoxygenase and cyclooxygenase.

  9. Data suggest that the production of 15d-PGJ2, which is mediated by cyclooxygenase 2 (COX-2), induces non-alcoholic fatty liver disease (NAFLD) and hepatic insulin (zeige INS Proteine) resistance by activating peroxisome proliferator-activated receptor gamma (PPARgamma (zeige PPARG Proteine)) .

  10. results suggest that Cox-2 is involved in the pathogenesis of noise-induced hearing loss; and pharmacological inhibition of Cox-2 has considerable therapeutic potential in noise-induced hearing loss.

Human Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) Interaktionspartner

  1. higher COX-2 expression levels in biopsy specimens may be used to decide re-biopsy in borderline preoperative PSA (zeige PLAG1 Proteine) levels as well as in the cases with suspicious pathological findings for cancer

  2. short hairpin-mediated silencing of SEMA7A (zeige SEMA7A Proteine) reveals roles for semaphorin 7a (zeige SEMA7A Proteine) in the promotion of DCIS growth, motility and invasion as well as lymphangiogenesis in the tumor microenvironment. Our studies also uncover a relationship between COX-2 and semaphorin 7a (zeige SEMA7A Proteine) expression and suggest that semaphorin 7a (zeige SEMA7A Proteine) promotes tumor cell invasion on collagen and lymphangiogenesis via activation of b1-integrin receptor

  3. Bisphenol A (BPA) induced COX-2 expression via nuclear translocation of NF-kappaB and activation of mitogen-activated protein kinase (MAPK) by phosphorylation of ERK1/2 and enhanced the migration of lung cancer A549 and breast cancer MDAMB-231 cells.

  4. Data show that in colorectal cancer SerpinB3 (zeige SERPINB3 Proteine), COX-2 and beta-Catenin (zeige CTNNB1 Proteine) are positively correlated and associated with more advanced tumor stage.

  5. Higher proliferation rate of NKT (zeige SLC22A6 Proteine) cells was also observed in non-metastatic and highly differentiated Laryngeal Cancer( LC), which was independent of the type of stimulation or treatment. COX-2 inhibition could be regarded as immunotherapy-enhancing tool in patients with LC.

  6. Data indicate that ellagic aicd (EA) down-regulates the expression of COX-2, NF-kappa B (zeige NFKB1 Proteine), vimentin (zeige VIM Proteine) and up-regulates the expression of E-cadherin (zeige CDH1 Proteine) in in pancreatic carcinom PANC-1 cells.

  7. YAP (zeige YAP1 Proteine) function is required for NF2 (zeige NF2 Proteine)-null Schwann cell survival, proliferation, and tumor growth in vivo Moreover, YAP (zeige YAP1 Proteine) promotes transcription of several targets including PTGS2, which codes for COX-2, a key enzyme in prostaglandin biosynthesis, and AREG (zeige AREG Proteine), which codes for the EGFR (zeige EGFR Proteine) ligand, amphiregulin (zeige AREG Proteine).

  8. The aspirin-mediated inactivation of platelets may restore antitumor reactivity by blocking the release of paracrine lipid and protein mediators that induce COX-2 expression in adjacent nucleated cells at sites of mucosal injury. [review]

  9. HULC enhanced the level of ubiquitin-specific peptidase 22 (USP22 (zeige USP22 Proteine)), which decreased ubiquitin-mediated degradation of COX-2 protein by removing the conjugated polyubiquitin (zeige UBB Proteine) chains from COX-2 and finally stabilized COX2 protein.

  10. COX-2 expression was significantly increased in wound edge amniotic membrane after fetoscopy compared with controls.

Pig (Porcine) Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) Interaktionspartner

  1. These findings suggest that nuclear factor kappa B(NF-kappaB (zeige NFKB1 Proteine)) and cyclooxygenase-2 play roles in epidermal cell regeneration following beta-irradiation of mini-pig skin.

  2. COX2 expression is upregulated in CAVD, and its activity contributes to osteogenic gene induction and valve calcification in vitro and in vivo.

  3. These results suggest that COX-2 plays a role in the pathogenesis of Mycoplasma hyopneumoniae -infection.

  4. Brain death increases the expression of COX-1 and COX-2 mRNA in the renal medulla

  5. COX-2 is differentially expressed in normal versus lungworm-infected lungs of pigs and is likely to be involved in the pathogenesis of porcine parasitic bronchopneumonia.

  6. In porcine vas (zeige AVP Proteine) deferens epithelial cell monolayers, increases in anion secretion were associated with preferential upregulation of PTGS2 at the mRNA and protein levels.

  7. expression appears to be positively and negatively regulated by p38 MAPK (zeige MAPK14 Proteine) and JNK (zeige MAPK8 Proteine) pathways; alternatively, ERK1/2 appear to be involved in COX-2-independent reparative events that remain to be defined

  8. Neutrophils augment recovery of transepithelial electrical resistance in ischemia-injured ileal mucosa via IL-1beta (zeige IL1B Proteine)-dependent upregulation of COX-2. (Cyclooxygenase 2)

  9. Administration of estrogen early in pregnancy alters endometrial prostaglandin-endoperoxide synthase 2 (PTGS2) mRNA and protein expression, which may disrupt pregnancy causing total embryonic loss during implantation in the pig.

  10. The effect of EGF (zeige EGF Proteine) on pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha (zeige TNF Proteine)) and cyclooxygenase-2 (COX-2), levels during wound healing in swine is reported.

Rabbit Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) Interaktionspartner

  1. results revealed that a transient episode of raised-intensity phonation causes a significant increase in vocal fold inflammatory mRNA expression - IL-1beta (zeige IL1B Proteine),COX-2, and TGFbeta1 (zeige TGFB1 Proteine)

  2. The result demonstrate that mechanical stress on synovial cells induces gene expressions of COX-2.

  3. Diabetes enhances the vasodilator response of the rabbit carotid artery to testosterone by a mechanism that includes an increased modulatory activity of the endothelial nitric oxide and an augmented release of COX-2 vasodilator, prostacyclin.

  4. Local induction of COX-2 during atherosclerosis decreased the sensitivity to norepinephrine and that COX-2 inhibitors may increase vascular reactivity at sites of atherosclerotic lesions.

Goat Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) Interaktionspartner

  1. The vesicular gland of castrated goats showed significantly lower AR and COX-2 immuno-expression than intact goats indicating that both AR and COX-2 are androgen dependent.

Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) Protein Überblick

Protein Überblick

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.

Alternative names and synonyms associated with Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2)

  • cyclooxygenase-2 (COX-2)
  • prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (PTGS2)
  • cyclooxygenase-2 (cox-2)
  • cyclooxygenase 2 (cox-2)
  • prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (ptgs2)
  • cytochrome c oxidase subunit II (COX2)
  • olfactory receptor, family 2, subfamily W, member 1-like (LOC782475)
  • prostaglandin-endoperoxide synthase 2 (Ptgs2)
  • CEF147 Protein
  • COII Protein
  • Cox-2 Protein
  • Cox2 Protein
  • GRIPGHS Protein
  • hCox-2 Protein
  • PGG/HS Protein
  • PGHS-2 Protein
  • PGHS2 Protein
  • PHS-2 Protein
  • PHSII Protein
  • PTGS2 Protein
  • TIS10 Protein

Bezeichner auf Proteinebene für PTGS2

cyclooxygenase-2 , cyclooxygenase 2 , prostaglandin G/H synthase 2 , prostaglandin G/H synthase and cyclooxygenase , prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) , prostaglandin G/H synthase 2-like , PES-2 , PGH synthase 2 , PHS II , glucocorticoid-regulated inflammatory cyclooxygenase , gripghs , macrophage activation-associated marker protein P71/73 , prostaglandin H2 synthase 2 , PGHS-2 , cyclooxygenase 2b , COX-2 , prostaglandin G/H synthase-2 , cyclooxygenase, prostaglandin endoperoxide H synthase-2 , prostaglandin H synthase-2 , cyclooxygenase type 2 , mitogen-inducible PGHS

GENE ID SPEZIES
100033836 Equus caballus
100126581 Felis catus
100136025 Oncorhynchus mykiss
100136456 Salmo salar
446781 Xenopus laevis
469616 Pan troglodytes
595089 Xenopus (Silurana) tropicalis
716671 Macaca mulatta
100407639 Callithrix jacchus
100436566 Pongo abelii
807845 Equus caballus
808252 Ovis aries
782475 Bos taurus
19225 Mus musculus
29527 Rattus norvegicus
100135607 Cavia porcellus
5743 Homo sapiens
282023 Bos taurus
791253 Equus caballus
443460 Ovis aries
442942 Canis lupus familiaris
397590 Sus scrofa
100009248 Oryctolagus cuniculus
396451 Gallus gallus
100860905 Capra hircus
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