PTGS2 Protein (AA 18-601, partial) (His tag)

Produktnummer ABIN5710177

Produktdetails

Target: PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2))

Protein-Typ: Recombinant

Proteineigenschaft: AA 18-601, partial

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses PTGS2 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: ANPCCSHPCQ NRGVCMSVGF DQYKCDCTRT GFYGENCSTP EFLTRIKLFL KPTPNTVHYI LTHFKGFWNV VNNIPFLRNA IMSYVLTSRS HLIDSPPTYN ADYGYKSWEA FSNLSYYTRA LPPVPDDCPT PLGVKGKKQL PDSNEIVEKL LLRRKFIPDP QGSNMMFAFF AQHFTHQFFK TDHKRGPAFT NGLGHGVDLN HIYGETLARQ RKLRLFKDGK MKYQIIDGEM YPPTVKDTQA EMIYPPQVPE HLRFAVGQEV FGLVPGLMMY ATIWLREHNR VCDVLKQEHP EWGDEQLFQT SRLILIGETI KIVIEDYVQH LSGYHFKLKF DPELLFNKQF QYQNRIAAEF NTLYHWHPLL PDTFQIHDQK YNYQQFIYNN SILLEHGITQ FVESFTRQIA GRVAGGRNVP PAVQKVSQAS IDQSRQMKYQ SFNEYRKRFM LKPYESFEEL TGEKEMSAEL EALYGDIDAV ELYPALLVEK PRPDAIFGET MVEVGAPFSL KGLMGNVICS PAYWKPSTFG GEVGFQIINT ASIQSLICNN VKGCPFTSFS VPDPELIKTV TINASSSRSG LDDINPTVLL KERS

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2))

Andere Bezeichnung: PGH2 (PTGS2 Produkte)

Synonyme: COX-2 Protein, COX2 Protein, GRIPGHS Protein, PGG/HS Protein, PGHS-2 Protein, PHS-2 Protein, hCox-2 Protein, Cox-2 Protein, Pghs2 Protein, TIS10 Protein, Cox2 Protein, cox-2 Protein, CEF147 Protein, PGHS2 Protein, PHSII Protein, cox2 Protein, gripghs Protein, pgg/hs Protein, pghs-2 Protein, phs-2 Protein, PTGS2 Protein, hcox-2 Protein, fj02a10 Protein, ptgs2 Protein, unp1239 Protein, wu:fj02a10 Protein, zCOX-2 Protein, si:dkey-97o5.6 Protein, prostaglandin-endoperoxide synthase 2 Protein, prostaglandin G/H synthase 2 Protein, prostaglandin-endoperoxide synthase 2S homeolog Protein, prostaglandin-endoperoxide synthase 2a Protein, prostaglandin-endoperoxide synthase 2b Protein, PTGS2 Protein, Ptgs2 Protein, LOC100136456 Protein, ptgs2.S Protein, ptgs2 Protein, ptgs2a Protein, ptgs2b Protein

Substanzklasse: Hormone

Hintergrund: Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

Molekulargewicht: 70.9 kDa

UniProt: P35354

Pathways: Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation