Thrombospondin 1 Proteine (THBS1)

Thrombospondin 1 Proteine (THBS1)
Auf finden Sie aktuell 50 Thrombospondin 1 (THBS1) Proteine von 13 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Thrombospondin 1 Antikörper (206) und Thrombospondin 1 Kits (61) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 324 Thrombospondin 1 Produkte verfügbar.
4833423O18Rik, CRISP-2, CT36, GAPDL5, si:dkey-11e23.1, tbsp1, thbs, thbs-1, THBS1, thrombospondin-1, Tmtsp, TPX1, tsp, Tsp-1, Tsp1, UNQ3010, wu:fc48c03
alle Proteine anzeigen Gen GeneID UniProt
THBS1 55901 Q9NS62
THBS1 364630  
THBS1 21825  

Weitere Synonyme anzeigen

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Weitere Proteine zu Thrombospondin 1 Interaktionspartnern

Zebrafish Thrombospondin 1 (THBS1) Interaktionspartner

  1. ELL (zeige ELL Proteine) (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation

Human Thrombospondin 1 (THBS1) Interaktionspartner

  1. Results show that the presence of OPN (zeige SPP1 Proteine) and TSP-1 in the serum of patients with non-small cell lung cancer may reflect the aggressiveness of the tumor.

  2. KLK4 (zeige KLK4 Proteine) further liberated an N-terminal product, with purported angiogenic activity, from thrombospondin-1 (TSP1) and cleaved TSP1 in an osteoblast-derived matrix.

  3. Data suggest pituitary cells secrete factor (TSP1) that binds to and inhibits action of BMP2 and BMP4; von Willebrand type C domain of TSP1 is likely responsible for this BMP2/4-binding activity. These studies were initially conducted using cultured cells from ovine pituitary gland and mouse cell line; interactions were confirmed using recombinant human proteins. (TSP1 = thrombospondin-1; BMP = bone morphogenetic protein)

  4. the results obtained by combining bioinformatics and preclinical studies strongly suggest that targeting TSP-1/CD47 (zeige CD47 Proteine) axis may represent a valuable therapeutic alternative for hampering melanoma spreading.

  5. The levels of CD36 (zeige CD36 Proteine), STAT3 (zeige STAT3 Proteine) and TGFbetaR2 mRNA were significantly higher in the TSP1-high group.

  6. Study discovered novel and independent associations of prediabetes and related traits with MASP1 (zeige MASP1 Proteine), and some evidence for associations with THBS1, GPLD1 (zeige GPLD1 Proteine) and ApoA-IV (zeige APOA4 Proteine), suggesting a role for these proteins in the pathophysiology of type 2 diabetes.

  7. TSP-1 deficiency promotes maladaptive remodelling of the ECM (zeige MMRN1 Proteine) leading to accelerated abdominal aortic aneurysms progression.

  8. Low THBS1 expression is associated with lung cancer.

  9. FGF7 (zeige FGF7 Proteine) stimulation of cell invasion and migration was partially suppressed by the FGFR2 (zeige FGFR2 Proteine) knockdown. In addition, FGF7 (zeige FGF7 Proteine)/FGFR2 (zeige FGFR2 Proteine) upregulated THBS1, and cell invasion and migration were decreased by knockdown of THBS1

  10. Introduces a computational model that describes the mechanistic interactions between intracellular biomolecules and cooperation between signaling pathways that together make up the complex network of TSP-1 regulation both at the transcriptional and post-transcriptional level.

Cow (Bovine) Thrombospondin 1 (THBS1) Interaktionspartner

  1. Data suggest THBS1 expression predominates in luteal endothelial cells; THBS2 (zeige THBS2 Proteine) expression predominates in luteinized granulosa cells. Luteinization down-regulates expression of THBS1/THBS2 (zeige THBS2 Proteine), up-regulates expression of FGF2 (fibroblast growth factor 2 (zeige FGF2 Proteine)).

  2. Thrombospondin has a role in inducing RhoA (zeige RHOA Proteine) inactivation through FAK (zeige PTK2 Proteine)-dependent signaling to stimulate focal adhesion disassembly

  3. Thrombospondin-1 and -2 were coordinately expressed in the extravascular compartment of the ovary during early follicle development. VEGF was inversely expressed, with expression increasing as follicles developed.

  4. Preincubation of erythroid cells with thrombospondin 1 eliminated the inhibitory activity of insulin (zeige INS Proteine)-like growth factor

  5. The cell-specific regulation of TSP-1 suggests a potential mechanism for the aberrant angiogenesis in diabetics and TSP-1 involvement in development of various vascular diabetic complications

  6. The novel finding that TSP-1-induced migration is dependent on the CD44 (zeige CD44 Proteine) receptor links 2 pathways thought to be disparate (ie, TSP-1 and HyA (zeige KDM5D Proteine)).

Mouse (Murine) Thrombospondin 1 (THBS1) Interaktionspartner

  1. HIF-1alpha (zeige HIF1A Proteine) induced angiogenesis by upregulating not only vascular endothelial growth factor but also miR (zeige MLXIP Proteine)-21 via inhibiting a novel target gene TSP-1 (zeige GZMA Proteine). Both of them may contribute to the protective effect of HIF-1alpha (zeige HIF1A Proteine) on renal I/R injury.

  2. the results obtained by combining bioinformatics and preclinical studies strongly suggest that targeting TSP-1 (zeige GZMA Proteine)/CD47 (zeige CD47 Proteine) axis may represent a valuable therapeutic alternative for hampering melanoma spreading.

  3. TSP-1 (zeige GZMA Proteine) deficiency promotes maladaptive remodelling of the ECM (zeige MMRN1 Proteine) leading to accelerated abdominal aortic aneurysms progression.

  4. TSP-1 (zeige GZMA Proteine) suppressed insulin (zeige INS Proteine) signaling in cultured muscle cells, which was accompanied by the activation of stress signaling such as JNK (zeige MAPK8 Proteine), p38 (zeige CRK Proteine), and IKK (zeige CHUK Proteine).

  5. Three transcription factors were overexpressed and eleven underexpressed in TSP1 (zeige GZMA Proteine)(-/-) compared to WT LGs (zeige LGSN Proteine).

  6. Data indicate that thrombospondin-1 may contribute to a destructive macrophage response in dysferlinopathy and pose the intriguing possibility that thrombospondin-1 levels may serve as a biomarker for disease progression.

  7. demonstrate that HIF-2alpha (zeige EPAS1 Proteine) is clearly implicated in the TSP1 (zeige GZMA Proteine) pulmonary regulation and provide new insights on its contribution to pulmonary arterial hypertension-driven vascular remodelling and vasoconstriction

  8. Thrombospondin-1 was differentially expressed according to tumor grade, but not affected by p53 (zeige TP53 Proteine) expression or mutational status

  9. Data suggest neutrophil protease- Tsp-1 (thrombospondin-1) axis as a potential antimetastatic therapeutic target.

  10. These results contribute new insights on the controversial role of TSP-1 (zeige GZMA Proteine) in cancer.

Pig (Porcine) Thrombospondin 1 (THBS1) Interaktionspartner

  1. These current studies were undertaken to determine how TSP-1 functions to modulate the smooth muscle cell response to IGF-I (zeige IGF1 Proteine) and the mechanisms by which hyperglycemia regulates TSP-1 protein.

  2. Increased TSP-1 expression in non-heart-beating donors may indicate a compensatory response to the reported diminished TGF-beta1 (zeige TGFB1 Proteine) expression.

Thrombospondin 1 (THBS1) Protein Überblick

Protein Überblick

May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation.

Alternative names and synonyms associated with Thrombospondin 1 (THBS1)

  • thrombospondin, type I, domain containing 1 (THSD1)
  • thrombospondin 1 (THBS1)
  • cysteine-rich secretory protein 2 (CRISP2)
  • thrombospondin, type I, domain containing 1 (Thsd1)
  • thrombospondin 1 (Thbs1)
  • thrombospondin 1 (thbs1)
  • thrombospondin 1 (LOC100230636)
  • thrombospondin, type I, domain 1 (Thsd1)
  • 4833423O18Rik Protein
  • CRISP-2 Protein
  • CT36 Protein
  • GAPDL5 Protein
  • si:dkey-11e23.1 Protein
  • tbsp1 Protein
  • thbs Protein
  • thbs-1 Protein
  • THBS1 Protein
  • thrombospondin-1 Protein
  • Tmtsp Protein
  • TPX1 Protein
  • tsp Protein
  • Tsp-1 Protein
  • Tsp1 Protein
  • UNQ3010 Protein
  • wu:fc48c03 Protein

Bezeichner auf Proteinebene für Thrombospondin 1 Proteine (THBS1)

4833423O18Rik , thrombospondin type-1 domain-containing protein 1 , thrombospondin, type I, domain 1 , transmembrane molecule with thrombospondin module , thrombospondin-1 , thrombospondin-1p180 , cancer/testis antigen 36 , glyceraldehyde-3-phosphate dehydrogenase-like 5 , testis specific protein 1 (probe H4-1 p3-1) , testis-specific protein TPX-1 , thrombospondin 1 , thrombospondin-1-like

55901 Homo sapiens
7057 Homo sapiens
7180 Homo sapiens
364630 Rattus norvegicus
21825 Mus musculus
281530 Bos taurus
373987 Gallus gallus
379508 Xenopus laevis
445442 Rattus norvegicus
453319 Pan troglodytes
487486 Canis lupus familiaris
492313 Sus scrofa
561901 Danio rerio
705413 Macaca mulatta
100170153 Xenopus (Silurana) tropicalis
100230636 Taeniopygia guttata
100294615 Ovis aries
100350430 Oryctolagus cuniculus
100390178 Callithrix jacchus
100453386 Pongo abelii
100465724 Ailuropoda melanoleuca
56229 Mus musculus
100057478 Equus caballus
100542373 Meleagris gallopavo
100603886 Nomascus leucogenys
101106433 Ovis aries
100727882 Cavia porcellus
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